SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		4 / 6 VAL A 711
GLY A 712
LEU A 795
GLU A 781
 None
 1.02A 1fduD-1kz7A:
undetectable		 1fduD-1kz7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		4 / 8 LEU A 831
LEU A 825
TYR A 821
SER A 894
 None
 1.25A 1hk2A-1kz7A:
undetectable		 1hk2A-1kz7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		3 / 3 GLU A 726
LYS A 807
VAL A 809
 None
 0.91A 1l2iA-1kz7A:
1.4		 1l2iA-1kz7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		5 / 10 PHE A 864
ILE A 818
ASP A 827
LEU A 828
GLY A 826
 None
 1.47A 2tsrC-1kz7A:
0.0		 2tsrC-1kz7A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		4 / 6 SER A 763
GLU A 650
TYR A 764
CYH A 653
 None
 1.32A 2x7hA-1kz7A:
undetectable		 2x7hA-1kz7A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		5 / 12 ILE A 802
TYR A 775
GLY A 712
LEU A 716
PHE A 697
 None
 1.20A 2y7kD-1kz7A:
undetectable		 2y7kD-1kz7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		4 / 7 VAL A 906
THR A 903
VAL A 923
ASP A 842
 None
 0.95A 2zaxA-1kz7A:
0.0		 2zaxA-1kz7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		4 / 7 VAL A 906
THR A 903
VAL A 923
ASP A 842
 None
 0.96A 3fwgB-1kz7A:
undetectable		 3fwgB-1kz7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		5 / 11 LEU A 779
LEU A 795
LEU A 716
GLY A 804
LEU A 803
 None
 1.35A 3hm1B-1kz7A:
1.5		 3hm1B-1kz7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		5 / 10 PHE A 692
GLU A 644
VAL A 711
TYR A 775
PHE A 715
 None
 1.26A 3r6wA-1kz7A:
0.0
3r6wB-1kz7A:
undetectable		 3r6wA-1kz7A:
22.35
3r6wB-1kz7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		5 / 8 ASN A 896
ALA A 869
LEU A 871
TYR A 821
LEU A 828
 None
 1.37A 4jjkA-1kz7A:
undetectable		 4jjkA-1kz7A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS
(Mus
musculus) 		4 / 6 LEU A 651
PRO A 768
GLU A 644
TYR A 647
 None
 1.24A 4z4gA-1kz7A:
undetectable		 4z4gA-1kz7A:
16.49