SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 VAL A  90
GLY A  87
SER A 178
PHE A 218
MET A 462
 None
None
SO4  A 601 (-2.4A)
None
None
 1.40A 1fdsA-1kzhA:
2.8		 1fdsA-1kzhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 ILE A  57
GLY A 479
LEU A 468
LEU A 446
TYR A 442
 None
 1.08A 1fm6X-1kzhA:
undetectable		 1fm6X-1kzhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.20A 1jffB-1kzhA:
2.0		 1jffB-1kzhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 GLY A 109
SER A 143
ILE A 173
LEU A  79
 None
 0.90A 1jg4A-1kzhA:
undetectable		 1jg4A-1kzhA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 SER A  59
ALA A 477
ILE A 476
ASN A 449
 None
 1.05A 1pnlA-1kzhA:
0.0
1pnlB-1kzhA:
0.0		 1pnlA-1kzhA:
15.29
1pnlB-1kzhA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 397
PHE A 398
ILE A 318
LEU A 314
ILE A 287
 None
 0.99A 1ra2A-1kzhA:
undetectable		 1ra2A-1kzhA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 397
PHE A 398
ILE A 318
LEU A 314
ILE A 287
 None
 1.00A 1rx2A-1kzhA:
undetectable		 1rx2A-1kzhA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		3 / 3 ILE A 465
ASP A 441
PHE A 438
 None
 0.61A 1uwjB-1kzhA:
undetectable		 1uwjB-1kzhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 137
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 0.94A 2f80B-1kzhA:
undetectable		 2f80B-1kzhA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 138
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 0.88A 2f80B-1kzhA:
undetectable		 2f80B-1kzhA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.20A 2hxfB-1kzhA:
2.4		 2hxfB-1kzhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.20A 2hxhB-1kzhA:
2.4		 2hxhB-1kzhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 6 ARG A 146
ASP A 208
SER A 178
GLY A 175
 SO4  A 600 ( 3.6A)
None
SO4  A 601 (-2.4A)
SO4  A 601 (-3.1A)
 0.95A 2j2pA-1kzhA:
0.0
2j2pC-1kzhA:
undetectable		 2j2pA-1kzhA:
17.65
2j2pC-1kzhA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 6 ARG A 146
ASP A 208
SER A 178
GLY A 175
 SO4  A 600 ( 3.6A)
None
SO4  A 601 (-2.4A)
SO4  A 601 (-3.1A)
 0.97A 2j2pD-1kzhA:
undetectable
2j2pF-1kzhA:
undetectable		 2j2pD-1kzhA:
17.65
2j2pF-1kzhA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.20A 2p4nB-1kzhA:
2.1		 2p4nB-1kzhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 137
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 0.95A 2pymA-1kzhA:
undetectable		 2pymA-1kzhA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 138
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 0.78A 2pymA-1kzhA:
undetectable		 2pymA-1kzhA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 137
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 1.01A 2pynA-1kzhA:
undetectable		 2pynA-1kzhA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 138
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 0.82A 2pynA-1kzhA:
undetectable		 2pynA-1kzhA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 137
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 1.01A 2pynB-1kzhA:
undetectable		 2pynB-1kzhA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 138
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 0.81A 2pynB-1kzhA:
undetectable		 2pynB-1kzhA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 138
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 0.84A 2q64A-1kzhA:
undetectable		 2q64A-1kzhA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 138
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 0.82A 2q64B-1kzhA:
undetectable		 2q64B-1kzhA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 138
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 0.79A 2qakA-1kzhA:
undetectable		 2qakA-1kzhA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 138
ASN A  89
VAL A  90
GLY A 219
ILE A 205
 None
 0.84A 2qakB-1kzhA:
undetectable		 2qakB-1kzhA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.20A 2wbeB-1kzhA:
undetectable		 2wbeB-1kzhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 ARG A 253
GLY A 427
PRO A  83
GLY A  81
 None
None
None
SO4  A 601 ( 3.8A)
 0.96A 2y6rB-1kzhA:
3.5		 2y6rB-1kzhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 174
GLY A 145
GLY A  81
LEU A  79
ASP A 382
 SO4  A 601 ( 3.9A)
None
SO4  A 601 ( 3.8A)
None
None
 1.01A 2zbpA-1kzhA:
undetectable		 2zbpA-1kzhA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 11 VAL A 321
LEU A 324
ILE A 378
LYS A 376
SER A 377
 None
 1.27A 3bjwH-1kzhA:
0.6		 3bjwH-1kzhA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 SER A  92
LEU A  79
ASN A  89
GLY A 138
 None
 0.81A 3dcjB-1kzhA:
2.7		 3dcjB-1kzhA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.20A 3dcoB-1kzhA:
undetectable		 3dcoB-1kzhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.20A 3edlB-1kzhA:
2.1		 3edlB-1kzhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.19A 3iz0B-1kzhA:
2.1		 3iz0B-1kzhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 GLY A 313
CYH A 329
PHE A 332
PHE A 351
 None
 1.09A 3ko0B-1kzhA:
1.6
3ko0J-1kzhA:
1.6		 3ko0B-1kzhA:
10.99
3ko0J-1kzhA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 7 GLY A 313
CYH A 329
PHE A 332
PHE A 351
 None
 1.12A 3ko0L-1kzhA:
undetectable
3ko0N-1kzhA:
undetectable		 3ko0L-1kzhA:
10.99
3ko0N-1kzhA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 7 GLY A 313
CYH A 329
PHE A 332
PHE A 351
 None
 1.13A 3ko0K-1kzhA:
1.6
3ko0S-1kzhA:
1.7		 3ko0K-1kzhA:
10.99
3ko0S-1kzhA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 7 GLY A 313
CYH A 329
PHE A 332
PHE A 351
 None
 1.06A 3ko0R-1kzhA:
1.7
3ko0T-1kzhA:
undetectable		 3ko0R-1kzhA:
10.99
3ko0T-1kzhA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 6 ILE A 205
PRO A 435
ILE A  91
GLY A  87
 None
 0.63A 3n3iA-1kzhA:
0.0		 3n3iA-1kzhA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		3 / 3 GLY A 174
ILE A  91
VAL A  90
 SO4  A 601 ( 3.9A)
None
None
 0.46A 3nv6A-1kzhA:
undetectable		 3nv6A-1kzhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 7 PRO A 202
LEU A 482
ASN A 211
ILE A 214
 None
 0.91A 3u5jA-1kzhA:
undetectable		 3u5jA-1kzhA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 PRO A 202
LEU A 482
ASN A 211
ILE A 214
 None
 0.90A 3u5kA-1kzhA:
0.0		 3u5kA-1kzhA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 PRO A 202
LEU A 482
ASN A 211
ILE A 214
 None
 0.87A 3u5kD-1kzhA:
undetectable		 3u5kD-1kzhA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		6 / 12 GLY A  76
ILE A 170
ASN A 165
ILE A  77
LEU A  73
ILE A  91
 None
 1.41A 4azvA-1kzhA:
undetectable		 4azvA-1kzhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 10 ILE A 173
LEU A  79
GLY A 447
GLY A  93
SER A  92
 None
 1.19A 4bwlC-1kzhA:
undetectable		 4bwlC-1kzhA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 479
LEU A 485
LEU A 468
LEU A 446
TYR A 442
 None
 0.98A 4emaA-1kzhA:
undetectable		 4emaA-1kzhA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 SER A 256
SER A 274
ILE A 287
GLU A 276
 None
 1.23A 4ms4A-1kzhA:
1.8		 4ms4A-1kzhA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		3 / 3 ARG A 253
ASP A 206
ARG A 146
 None
None
SO4  A 600 ( 3.6A)
 0.73A 4mx0A-1kzhA:
undetectable		 4mx0A-1kzhA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		6 / 12 GLY A 113
PRO A 114
GLY A 145
PHE A 139
ILE A 123
LEU A 125
 None
 1.32A 4n49A-1kzhA:
undetectable		 4n49A-1kzhA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 397
PHE A 398
ILE A 318
LEU A 314
ILE A 287
 None
 1.00A 4nx6A-1kzhA:
undetectable		 4nx6A-1kzhA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 397
PHE A 398
ILE A 318
LEU A 314
ILE A 287
 None
 1.02A 4nx7A-1kzhA:
undetectable		 4nx7A-1kzhA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 397
PHE A 398
ILE A 318
LEU A 314
ILE A 287
 None
 1.01A 4p3rA-1kzhA:
undetectable		 4p3rA-1kzhA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 ASN A 456
GLY A 457
GLN A 197
LEU A  73
ILE A  28
 None
 1.34A 4p6xA-1kzhA:
undetectable		 4p6xA-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 453
ASN A 456
GLY A 457
GLN A 197
ILE A  28
 None
 1.41A 4p6xA-1kzhA:
undetectable		 4p6xA-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 455
ASN A 456
GLY A 457
GLN A 197
ILE A  28
 None
 1.44A 4p6xA-1kzhA:
undetectable		 4p6xA-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 453
ASN A 456
GLY A 457
GLN A 197
ILE A  28
 None
 1.44A 4p6xE-1kzhA:
undetectable		 4p6xE-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 455
ASN A 456
GLY A 457
GLN A 197
ILE A  28
 None
 1.40A 4p6xE-1kzhA:
undetectable		 4p6xE-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 ASN A 456
GLY A 457
GLN A 197
LEU A  73
ILE A  28
 None
 1.35A 4p6xG-1kzhA:
undetectable		 4p6xG-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 ASN A 456
GLY A 457
GLN A 197
LEU A  73
ILE A  28
 None
 1.40A 4p6xI-1kzhA:
undetectable		 4p6xI-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 455
ASN A 456
GLY A 457
GLN A 197
ILE A  28
 None
 1.44A 4p6xI-1kzhA:
undetectable		 4p6xI-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 397
PHE A 398
ILE A 318
LEU A 314
ILE A 287
 None
 1.03A 4pstA-1kzhA:
undetectable		 4pstA-1kzhA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 TYR A 527
THR A 266
HIS A 246
TRP A 245
 None
 1.25A 4tzcB-1kzhA:
0.0
4tzcD-1kzhA:
0.0		 4tzcB-1kzhA:
13.32
4tzcD-1kzhA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 ASN A 102
PRO A 103
PHE A 101
TYR A 448
 SO4  A 602 (-3.5A)
None
None
None
 1.41A 4v2zC-1kzhA:
0.0		 4v2zC-1kzhA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 THR A 241
ALA A 238
ASP A 237
LEU A 234
ARG A 298
 None
 1.34A 4xi3A-1kzhA:
undetectable		 4xi3A-1kzhA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 5 GLY A 252
ARG A 253
GLY A 313
GLU A 316
 None
 1.17A 4z2eB-1kzhA:
0.0
4z2eC-1kzhA:
2.1		 4z2eB-1kzhA:
23.14
4z2eC-1kzhA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.16A 5hnwB-1kzhA:
undetectable		 5hnwB-1kzhA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.20A 5hnyB-1kzhA:
2.2		 5hnyB-1kzhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.14A 5hnzB-1kzhA:
undetectable		 5hnzB-1kzhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 6 ARG A 146
ASP A 208
GLY A 175
ASP A 176
 SO4  A 600 ( 3.6A)
None
SO4  A 601 (-3.1A)
SO4  A 601 (-3.8A)
 1.31A 5hp1A-1kzhA:
undetectable		 5hp1A-1kzhA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		3 / 3 ARG A  10
PRO A 435
ASN A  89
 None
 0.89A 5jwaA-1kzhA:
2.8
5jwaH-1kzhA:
undetectable		 5jwaA-1kzhA:
23.11
5jwaH-1kzhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		3 / 3 LYS A 396
LEU A 366
ILE A 315
 None
 0.61A 5kc4A-1kzhA:
undetectable		 5kc4A-1kzhA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 6 GLU A  37
PHE A  49
THR A  52
TYR A  53
 None
 1.26A 5lrbA-1kzhA:
1.4		 5lrbA-1kzhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 VAL A 308
ILE A 402
ILE A 288
SER A 274
 None
 0.72A 5numA-1kzhA:
undetectable		 5numA-1kzhA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 5 ASP A 382
ASN A 386
ASP A 176
ASN A 181
 None
None
SO4  A 601 (-3.8A)
None
 1.22A 5vooA-1kzhA:
undetectable		 5vooA-1kzhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 5 ASP A 382
ASN A 386
ASP A 176
ASN A 181
 None
None
SO4  A 601 (-3.8A)
None
 1.23A 5vooE-1kzhA:
undetectable		 5vooE-1kzhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 4 ASP A 382
ASN A 386
ASP A 176
ASN A 181
 None
None
SO4  A 601 (-3.8A)
None
 1.20A 5vooF-1kzhA:
0.3		 5vooF-1kzhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 ALA A  84
PRO A  85
GLY A 430
ILE A 173
GLY A 145
 None
 1.13A 5wwsB-1kzhA:
undetectable		 5wwsB-1kzhA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 112
ILE A 172
LEU A 117
GLY A 116
GLY A 113
 None
 1.00A 5wyqB-1kzhA:
undetectable		 5wyqB-1kzhA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 397
PHE A 398
ILE A 318
LEU A 314
ILE A 287
 None
 0.98A 5z6jA-1kzhA:
undetectable		 5z6jA-1kzhA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 397
PHE A 398
ILE A 318
LEU A 314
ILE A 287
 None
 0.97A 5z6kA-1kzhA:
undetectable		 5z6kA-1kzhA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		5 / 10 ILE A 123
ILE A 454
ALA A 169
LEU A 167
ALA A 162
 None
 1.36A 5zjiB-1kzhA:
undetectable		 5zjiB-1kzhA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1kzh PHOSPHOFRUCTOKINASE
(Borreliella
burgdorferi) 		4 / 8 ASP A 177
HIS A 384
GLU A 489
GLU A 316
 SO4  A 601 (-4.0A)
None
None
None
 1.26A 6mn4C-1kzhA:
undetectable		 6mn4C-1kzhA:
20.08