SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l0b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 1l0b BRCA1
(Rattus
norvegicus) 		4 / 6 TYR A1649
ASP A1685
PHE A1650
ASP A1785
 None
 1.40A 2todA-1l0bA:
0.0
2todB-1l0bA:
undetectable		 2todA-1l0bA:
19.91
2todB-1l0bA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1l0b BRCA1
(Rattus
norvegicus) 		4 / 5 ARG A1791
ARG A1696
GLY A1694
GLU A1681
 None
 1.21A 3k9fA-1l0bA:
0.0
3k9fB-1l0bA:
0.0
3k9fC-1l0bA:
1.4		 3k9fA-1l0bA:
17.94
3k9fB-1l0bA:
17.94
3k9fC-1l0bA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1l0b BRCA1
(Rattus
norvegicus) 		5 / 9 LEU A1725
ILE A1626
GLY A1652
ILE A1653
LEU A1729
 None
 0.95A 3u7sA-1l0bA:
undetectable		 3u7sA-1l0bA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1l0b BRCA1
(Rattus
norvegicus) 		3 / 3 VAL A1753
LEU A1777
VAL A1755
 None
 0.50A 4wq4A-1l0bA:
undetectable		 4wq4A-1l0bA:
21.27