SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l0q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		5 / 9 SER A 291
GLY A 292
ALA A 122
LEU A 121
GLY A  78
 None
 1.40A 1jb0A-1l0qA:
0.0		 1jb0A-1l0qA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		3 / 3 LYS A 113
ILE A 143
THR A 139
 None
 0.76A 1rx3A-1l0qA:
undetectable		 1rx3A-1l0qA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		3 / 3 LEU A 320
LEU A 384
SER A 387
 None
 0.58A 1tlmA-1l0qA:
undetectable		 1tlmA-1l0qA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		5 / 12 GLU A 210
GLY A 255
ASP A 254
ASN A 208
ALA A 250
 None
 1.33A 2bm9B-1l0qA:
undetectable		 2bm9B-1l0qA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 5 PHE A 309
PHE A 326
TRP A 338
GLY A 341
 None
 1.17A 2qmzA-1l0qA:
0.0
2qmzB-1l0qA:
undetectable		 2qmzA-1l0qA:
19.21
2qmzB-1l0qA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		5 / 12 ILE A 205
ILE A 163
GLY A 292
ALA A 164
ALA A  37
 None
 1.00A 2yvlC-1l0qA:
undetectable		 2yvlC-1l0qA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 280
VAL A 284
ILE A  17
MET A 282
THR A 267
 None
None
None
None
YCM  A 265 ( 3.5A)
 1.23A 3dl9A-1l0qA:
undetectable		 3dl9A-1l0qA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		3 / 3 ASN A 224
ASP A 245
ARG A 158
 None
 0.76A 3k13A-1l0qA:
undetectable		 3k13A-1l0qA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		3 / 3 ARG A 364
THR A 334
THR A  27
 None
 0.80A 3k2hB-1l0qA:
undetectable		 3k2hB-1l0qA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		5 / 9 SER A 291
GLY A 292
ALA A 122
LEU A 121
GLY A  78
 None
 1.41A 3pcqA-1l0qA:
0.0		 3pcqA-1l0qA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 5 ILE A 295
PRO A 253
SER A   1
GLY A 296
 None
 0.96A 3tkdB-1l0qA:
undetectable		 3tkdB-1l0qA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 5 ILE A 295
PRO A 253
SER A   1
GLY A 296
 None
 0.95A 3tkdA-1l0qA:
undetectable		 3tkdA-1l0qA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		3 / 3 PHE A 294
VAL A  30
ILE A  28
 None
 0.50A 4emaA-1l0qA:
undetectable		 4emaA-1l0qA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 8 VAL A 112
ILE A 143
SER A  99
ALA A  80
 None
 0.94A 4eyzA-1l0qA:
undetectable		 4eyzA-1l0qA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 8 VAL A 112
ILE A 143
SER A  99
ALA A  80
 None
 0.95A 4eyzB-1l0qA:
undetectable		 4eyzB-1l0qA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		3 / 3 LYS A 113
ILE A 143
THR A 139
 None
 0.78A 4gh8A-1l0qA:
undetectable		 4gh8A-1l0qA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 7 PRO A  76
SER A  75
VAL A  48
MET A  35
 None
 1.48A 4kmmA-1l0qA:
undetectable		 4kmmA-1l0qA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		5 / 12 THR A   2
ALA A   4
ILE A   6
ALA A 290
ILE A  17
 None
 0.84A 4o2bD-1l0qA:
undetectable		 4o2bD-1l0qA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 7 PHE A 294
ILE A   6
GLY A 248
THR A 217
 None
 0.91A 4zdzA-1l0qA:
undetectable		 4zdzA-1l0qA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 7 PHE A 294
ILE A   6
GLY A 248
THR A 217
 None
 0.89A 4ze3A-1l0qA:
undetectable		 4ze3A-1l0qA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 8 PHE A 294
ILE A   6
GLY A 248
THR A 217
 None
 0.91A 5eseA-1l0qA:
undetectable		 5eseA-1l0qA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 8 PHE A 294
ILE A   6
GLY A 248
THR A 217
 None
 0.90A 5esfA-1l0qA:
undetectable		 5esfA-1l0qA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 8 PHE A 294
ILE A   6
GLY A 248
THR A 217
 None
 0.87A 5esjA-1l0qA:
0.0		 5esjA-1l0qA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 7 PHE A 294
ILE A   6
GLY A 248
THR A 217
 None
 0.93A 5esmA-1l0qA:
undetectable		 5esmA-1l0qA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		3 / 3 PRO A  41
ILE A  17
SER A  82
 None
 0.66A 5fsaA-1l0qA:
undetectable		 5fsaA-1l0qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		4 / 8 PHE A 294
ILE A   6
GLY A 248
THR A 217
 None
 0.87A 5hs1A-1l0qA:
undetectable		 5hs1A-1l0qA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		5 / 12 VAL A  88
GLN A  87
PRO A  71
ALA A  72
VAL A  90
 None
 1.20A 5hv1A-1l0qA:
2.8		 5hv1A-1l0qA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		5 / 9 SER A 291
GLY A 292
ALA A 122
LEU A 121
GLY A  78
 None
 1.44A 5l8rA-1l0qA:
0.0		 5l8rA-1l0qA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		3 / 3 LYS A 348
TRP A 336
SER A 346
 None
 1.28A 5nwwA-1l0qA:
0.0		 5nwwA-1l0qA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		5 / 12 THR A   2
ALA A   4
ILE A   6
ALA A 290
ILE A  17
 None
 0.88A 5xiwB-1l0qA:
undetectable		 5xiwB-1l0qA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		5 / 12 GLN A 293
ALA A 122
ALA A 247
GLY A 248
THR A 217
 None
 0.89A 6hwdH-1l0qA:
undetectable
6hwdI-1l0qA:
undetectable		 6hwdH-1l0qA:
14.43
6hwdI-1l0qA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1l0q SURFACE LAYER
PROTEIN
(Methanosarcina
mazei) 		5 / 11 GLN A 293
ALA A 122
ALA A 247
GLY A 248
THR A 217
 None
 0.89A 6hwdV-1l0qA:
undetectable		 6hwdV-1l0qA:
14.43