SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 391
LEU A 400
VAL A 403
SER A 319
ALA A 317
 None
 0.98A 1dfoA-1l0wA:
undetectable		 1dfoA-1l0wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 391
LEU A 400
VAL A 403
SER A 319
ALA A 317
 None
 0.98A 1dfoB-1l0wA:
undetectable		 1dfoB-1l0wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 391
LEU A 400
VAL A 403
SER A 319
ALA A 317
 None
 0.98A 1dfoC-1l0wA:
undetectable		 1dfoC-1l0wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 391
LEU A 400
VAL A 403
SER A 319
ALA A 317
 None
 0.98A 1dfoD-1l0wA:
undetectable		 1dfoD-1l0wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 SER A 123
GLU A 124
GLU A 125
 None
 0.65A 1eqbD-1l0wA:
1.1		 1eqbD-1l0wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 SER A 123
GLU A 124
GLU A 125
 None
 0.66A 1eqbB-1l0wA:
1.1		 1eqbB-1l0wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 391
LEU A 400
VAL A 403
SER A 319
ALA A 317
 None
 0.95A 1eqbC-1l0wA:
undetectable		 1eqbC-1l0wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LEU A 146
MET A 536
LEU A 532
MET A 258
 None
 1.15A 1linA-1l0wA:
0.1		 1linA-1l0wA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 PHE A 548
LEU A 135
LEU A 144
 None
 0.62A 1mx1E-1l0wA:
undetectable		 1mx1E-1l0wA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 ARG A  42
HIS A  14
SER A   9
ARG A   3
 None
 1.26A 1u1jA-1l0wA:
undetectable		 1u1jA-1l0wA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 SER A 481
LEU A 428
LEU A 202
PHE A 494
 None
 1.00A 1wrlC-1l0wA:
undetectable
1wrlD-1l0wA:
undetectable		 1wrlC-1l0wA:
8.98
1wrlD-1l0wA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLU A 124
ARG A 127
GLU A 544
MET A 140
ASP A 134
 None
 1.09A 2qeoA-1l0wA:
undetectable		 2qeoA-1l0wA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 391
LEU A 400
VAL A 403
SER A 319
ALA A 317
 None
 1.02A 2vmyA-1l0wA:
undetectable		 2vmyA-1l0wA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 ASP A 230
ASP A 530
LEU A 144
ARG A 131
ARG A 127
 None
 1.48A 2ya7C-1l0wA:
undetectable		 2ya7C-1l0wA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 PRO A 454
LEU A 455
ARG A 462
 None
 0.88A 3aqiA-1l0wA:
undetectable		 3aqiA-1l0wA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 ILE A 484
SER A 447
PRO A 448
PRO A 450
 None
 1.40A 3bjwC-1l0wA:
undetectable		 3bjwC-1l0wA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 PRO A 557
PHE A 548
LYS A 550
 None
 1.19A 3bjwG-1l0wA:
undetectable		 3bjwG-1l0wA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 4 PRO A 291
TYR A 286
GLY A 287
THR A 398
 None
 1.36A 3ib0A-1l0wA:
undetectable		 3ib0A-1l0wA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 PRO A 564
PRO A 566
GLN A 569
GLU A 568
 None
 1.05A 3oyaA-1l0wA:
undetectable		 3oyaA-1l0wA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 PHE A 511
ALA A 514
ALA A 519
PRO A 520
 None
 1.02A 4dtzB-1l0wA:
0.0		 4dtzB-1l0wA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 ILE A 151
LEU A 529
ASP A 530
THR A 537
 None
 0.87A 4mmcA-1l0wA:
0.0		 4mmcA-1l0wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 391
PHE A 388
ALA A 350
VAL A 363
GLN A 347
 None
 0.97A 4ryaA-1l0wA:
0.0		 4ryaA-1l0wA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 ALA A  56
SER A  54
VAL A  49
ILE A  35
PRO A  52
 None
 1.24A 5mlmA-1l0wA:
undetectable		 5mlmA-1l0wA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 LEU A  97
VAL A  69
ARG A  28
VAL A  25
 None
 0.97A 5x7zA-1l0wA:
0.5		 5x7zA-1l0wA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 HIS A 443
SER A 481
TYR A 468
GLY A 480
 None
 1.05A 5yodH-1l0wA:
undetectable		 5yodH-1l0wA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 GLN A 141
TRP A 114
VAL A 110
 None
 0.87A 6auuA-1l0wA:
0.0		 6auuA-1l0wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 VAL A 150
HIS A 148
LEU A 535
ALA A 534
ASP A 530
 None
 0.97A 6c2mB-1l0wA:
0.0		 6c2mB-1l0wA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 VAL A 150
HIS A 148
LEU A 535
ARG A 147
ASP A 530
 None
 1.34A 6c2mB-1l0wA:
0.0		 6c2mB-1l0wA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 VAL A 150
HIS A 148
LEU A 535
ARG A 147
ASP A 530
 None
 1.32A 6c2mC-1l0wA:
undetectable		 6c2mC-1l0wA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 9 VAL A 150
HIS A 148
LEU A 535
ASP A 530
 None
 0.76A 6c2mD-1l0wA:
undetectable		 6c2mD-1l0wA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1l0w ASPARTYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 VAL A 150
ILE A 218
MET A 242
GLY A 523
 None
 0.81A 6hd6B-1l0wA:
undetectable		 6hd6B-1l0wA:
12.88