SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		4 / 7 PHE A  84
VAL A  40
ILE A 158
GLY A 161
 None
 0.95A 11gsA-1l1jA:
undetectable		 11gsA-1l1jA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 10 ALA A 223
LEU A 194
LEU A 210
PHE A 235
ILE A 201
 None
 1.25A 1g5yC-1l1jA:
undetectable		 1g5yC-1l1jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		3 / 3 ALA A 199
VAL A 174
TRP A 156
 None
 0.82A 1nt6A-1l1jA:
undetectable		 1nt6A-1l1jA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		3 / 3 ALA A 199
VAL A 174
TRP A 156
 None
 0.83A 1nt6B-1l1jA:
undetectable		 1nt6B-1l1jA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 12 ILE A  43
GLY A  83
THR A  94
ASN A 162
ALA A  39
 None
 0.95A 1nv8A-1l1jA:
undetectable		 1nv8A-1l1jA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		4 / 8 PHE A  84
VAL A  40
ILE A 158
GLY A 161
 None
 0.95A 2gssB-1l1jA:
undetectable		 2gssB-1l1jA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 11 GLY A 100
ALA A 102
ASP A 103
VAL A 107
ILE A 105
 None
 0.87A 2r5qB-1l1jA:
undetectable		 2r5qB-1l1jA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 11 ASN A 212
GLY A 154
THR A 197
ILE A 195
THR A 178
 None
 1.36A 3bexC-1l1jA:
undetectable
3bexD-1l1jA:
undetectable		 3bexC-1l1jA:
23.19
3bexD-1l1jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 10 THR A 178
ASN A 212
GLY A 154
THR A 197
ILE A 195
 None
 1.35A 3bexC-1l1jA:
undetectable
3bexD-1l1jA:
undetectable		 3bexC-1l1jA:
23.19
3bexD-1l1jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 10 ASN A 212
GLY A 154
THR A 197
ILE A 195
THR A 178
 None
 1.37A 3bexE-1l1jA:
undetectable
3bexF-1l1jA:
undetectable		 3bexE-1l1jA:
23.19
3bexF-1l1jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 11 THR A 178
ASN A 212
GLY A 154
THR A 197
ILE A 195
 None
 1.36A 3bexE-1l1jA:
undetectable
3bexF-1l1jA:
undetectable		 3bexE-1l1jA:
23.19
3bexF-1l1jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 11 ASN A 212
GLY A 154
THR A 197
ILE A 195
THR A 178
 None
 1.34A 3bf1C-1l1jA:
undetectable
3bf1D-1l1jA:
undetectable		 3bf1C-1l1jA:
23.19
3bf1D-1l1jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 11 THR A 178
ASN A 212
GLY A 154
THR A 197
ILE A 195
 None
 1.35A 3bf1C-1l1jA:
undetectable
3bf1D-1l1jA:
undetectable		 3bf1C-1l1jA:
23.19
3bf1D-1l1jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 11 ASN A 212
GLY A 154
THR A 197
ILE A 195
THR A 178
 None
 1.37A 3bf1E-1l1jA:
undetectable
3bf1F-1l1jA:
undetectable		 3bf1E-1l1jA:
23.19
3bf1F-1l1jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 11 THR A 178
ASN A 212
GLY A 154
THR A 197
ILE A 195
 None
 1.37A 3bf1E-1l1jA:
undetectable
3bf1F-1l1jA:
undetectable		 3bf1E-1l1jA:
23.19
3bf1F-1l1jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		3 / 3 GLU A 125
LEU A 126
ASP A 127
 None
 0.44A 3ko0A-1l1jA:
undetectable		 3ko0A-1l1jA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		3 / 3 GLU A 125
LEU A 126
ASP A 127
 None
 0.42A 3ko0T-1l1jA:
undetectable		 3ko0T-1l1jA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		4 / 8 GLU A 155
HIS A 214
ASN A 212
ILE A 158
 None
 1.07A 3kp6A-1l1jA:
undetectable
3kp6B-1l1jA:
undetectable		 3kp6A-1l1jA:
17.15
3kp6B-1l1jA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 11 TYR A  96
HIS A  97
ASP A 127
GLY A 204
SER A 206
 None
 0.94A 3sufC-1l1jA:
8.0		 3sufC-1l1jA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 12 THR A 169
ASN A 221
SER A 206
VAL A  98
ASP A  44
 None
 1.45A 4njgB-1l1jA:
undetectable		 4njgB-1l1jA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 12 GLY A  83
GLY A 208
GLY A 207
PHE A  62
GLY A 161
 None
 0.83A 4o33A-1l1jA:
undetectable		 4o33A-1l1jA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 12 GLY A 207
ASP A 127
ILE A 131
VAL A 107
ILE A 133
 None
 0.98A 4q5mA-1l1jA:
undetectable		 4q5mA-1l1jA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 9 ALA A 159
SER A 148
GLY A 219
ALA A 236
VAL A 175
 None
 1.17A 4r1zA-1l1jA:
undetectable		 4r1zA-1l1jA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 12 GLY A  81
GLY A 207
PRO A 203
ALA A 223
ALA A 129
 None
 1.15A 5bw4B-1l1jA:
undetectable		 5bw4B-1l1jA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 12 GLY A  81
GLY A 207
PRO A 203
ALA A 223
LEU A  80
 None
 1.25A 5bw4B-1l1jA:
undetectable		 5bw4B-1l1jA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 12 LEU A 246
SER A 148
GLU A 216
PHE A 145
ASN A 212
 None
 1.18A 5il1A-1l1jA:
undetectable		 5il1A-1l1jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		5 / 12 GLY A 219
GLY A  83
GLY A 207
VAL A 107
ILE A  92
 None
 0.96A 5vimB-1l1jA:
undetectable		 5vimB-1l1jA:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 1l1j HEAT SHOCK PROTEASE
HTRA
(Thermotoga
maritima) 		3 / 3 GLU A 144
ASP A  87
PRO A  88
 None
 0.64A 6berA-1l1jA:
undetectable		 6berA-1l1jA:
40.00