SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 ALA A 321
VAL A 163
TRP A 120
 None
 0.87A 1av2A-1l1lA:
undetectable
1av2B-1l1lA:
undetectable		 1av2A-1l1lA:
2.70
1av2B-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 ALA A 646
VAL A 547
TRP A 642
 None
 0.91A 1av2A-1l1lA:
undetectable
1av2B-1l1lA:
undetectable		 1av2A-1l1lA:
2.70
1av2B-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 8 ASP A 155
ASP A 456
TRP A 457
TYR A 129
 None
 1.20A 1ceaA-1l1lA:
0.0
1ceaB-1l1lA:
0.0		 1ceaA-1l1lA:
8.87
1ceaB-1l1lA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 12 ALA A 232
ILE A 235
LEU A 277
LEU A 184
LEU A 250
 None
 1.12A 1dtlA-1l1lA:
0.0		 1dtlA-1l1lA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 11 ILE A 235
PHE A 150
ILE A 175
PRO A 176
ILE A 124
 None
 1.08A 1dyrA-1l1lA:
undetectable		 1dyrA-1l1lA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 ALA A 646
VAL A 547
TRP A 642
 None
 0.87A 1gmkA-1l1lA:
undetectable
1gmkB-1l1lA:
undetectable		 1gmkA-1l1lA:
2.70
1gmkB-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 ALA A 646
VAL A 547
TRP A 642
 None
 0.89A 1gmkC-1l1lA:
undetectable
1gmkD-1l1lA:
undetectable		 1gmkC-1l1lA:
2.70
1gmkD-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 GLN A 109
TYR A 446
ARG A 445
 None
 0.81A 1gtbA-1l1lA:
0.0		 1gtbA-1l1lA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 ASP A 644
ASP A 392
LYS A 673
 None
 1.02A 1lqtB-1l1lA:
undetectable		 1lqtB-1l1lA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 ASP A 644
ASP A 392
LYS A 673
 None
 1.02A 1lquB-1l1lA:
undetectable		 1lquB-1l1lA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 ALA A 321
VAL A 163
TRP A 120
 None
 0.87A 1w5uA-1l1lA:
undetectable
1w5uB-1l1lA:
undetectable		 1w5uA-1l1lA:
2.70
1w5uB-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 ALA A 646
VAL A 547
TRP A 642
 None
 0.90A 1w5uA-1l1lA:
undetectable
1w5uB-1l1lA:
undetectable		 1w5uA-1l1lA:
2.70
1w5uB-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 TRP A 120
ALA A 321
VAL A 163
 None
 0.96A 1w5uA-1l1lA:
undetectable
1w5uB-1l1lA:
undetectable		 1w5uA-1l1lA:
2.70
1w5uB-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 TRP A 642
ALA A 646
VAL A 547
 None
 0.92A 1w5uA-1l1lA:
undetectable
1w5uB-1l1lA:
undetectable		 1w5uA-1l1lA:
2.70
1w5uB-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 12 GLY A 558
GLY A  24
GLY A  27
ASP A 479
HIS A 566
 None
 1.18A 1wg8A-1l1lA:
undetectable		 1wg8A-1l1lA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 12 GLY A 558
GLY A  24
GLY A  27
ASP A 479
HIS A 566
 None
 1.16A 1wg8B-1l1lA:
undetectable		 1wg8B-1l1lA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 8 VAL A 163
GLY A 162
VAL A 312
ILE A 308
 None
 0.73A 2a1mB-1l1lA:
0.0		 2a1mB-1l1lA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 TRP A 120
ALA A 321
VAL A 163
 None
 0.98A 2izqC-1l1lA:
undetectable
2izqD-1l1lA:
undetectable		 2izqC-1l1lA:
2.70
2izqD-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 TRP A 642
ALA A 646
VAL A 547
 None
 0.93A 2izqC-1l1lA:
undetectable
2izqD-1l1lA:
undetectable		 2izqC-1l1lA:
2.70
2izqD-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 5 SER A 674
SER A 353
VAL A 379
SER A 676
 None
 1.14A 2j9cA-1l1lA:
0.0
2j9cB-1l1lA:
0.0
2j9cC-1l1lA:
0.0		 2j9cA-1l1lA:
10.55
2j9cB-1l1lA:
10.55
2j9cC-1l1lA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 7 SER A 674
SER A 353
VAL A 379
SER A 676
 None
 1.14A 2j9cA-1l1lA:
0.0
2j9cB-1l1lA:
0.0
2j9cC-1l1lA:
0.0		 2j9cA-1l1lA:
10.55
2j9cB-1l1lA:
10.55
2j9cC-1l1lA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 7 ASP A 114
THR A 112
ILE A 103
PHE A 267
 None
 1.25A 2jc9A-1l1lA:
0.5		 2jc9A-1l1lA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_B_CHDB1_0
(FERROCHELATASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 10 LEU A 250
PRO A 136
SER A 137
VAL A 228
GLY A 226
 None
 1.25A 2qd2B-1l1lA:
2.7		 2qd2B-1l1lA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		6 / 12 ALA A 302
ASP A 303
ASP A 300
ILE A 172
ILE A 334
ALA A 168
 None
 1.33A 2rkfB-1l1lA:
undetectable		 2rkfB-1l1lA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 GLY A  27
GLY A 558
GLY A  24
 None
 0.43A 3bogC-1l1lA:
0.0		 3bogC-1l1lA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 8 VAL A  55
THR A  95
TYR A  35
VAL A  52
 None
 0.78A 3fhxB-1l1lA:
undetectable		 3fhxB-1l1lA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 12 LEU A 184
LEU A 250
GLN A 211
LEU A 220
ASP A 253
 None
 1.35A 3gwuA-1l1lA:
0.0		 3gwuA-1l1lA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 7 LEU A 250
PRO A 136
SER A 137
GLY A 226
 None
 1.11A 3hcnA-1l1lA:
undetectable		 3hcnA-1l1lA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 7 LEU A 250
PRO A 136
SER A 137
GLY A 226
 None
 1.06A 3hcrB-1l1lA:
undetectable		 3hcrB-1l1lA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 TRP A 120
ALA A 321
VAL A 163
 None
 0.97A 3l8lC-1l1lA:
undetectable
3l8lD-1l1lA:
undetectable		 3l8lC-1l1lA:
2.70
3l8lD-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 TRP A 642
ALA A 646
VAL A 547
 None
 0.88A 3l8lC-1l1lA:
undetectable
3l8lD-1l1lA:
undetectable		 3l8lC-1l1lA:
2.70
3l8lD-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0Q_A_ADNA1004_1
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 9 ASN A 351
SER A 353
GLY A 377
SER A 648
THR A 650
 None
 0.93A 3o0qA-1l1lA:
1.2		 3o0qA-1l1lA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0Q_A_ADNA1004_1
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 9 SER A 353
GLY A 377
CYH A 408
SER A 648
THR A 650
 None
 0.74A 3o0qA-1l1lA:
1.2		 3o0qA-1l1lA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 10 VAL A  15
ALA A  82
VAL A  56
TYR A  90
ILE A  12
 None
 1.04A 3retA-1l1lA:
undetectable
3retB-1l1lA:
undetectable		 3retA-1l1lA:
8.57
3retB-1l1lA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 11 SER A 151
VAL A 122
PHE A 165
VAL A 163
ILE A 124
 None
 1.25A 3rf4A-1l1lA:
0.1
3rf4C-1l1lA:
0.2		 3rf4A-1l1lA:
11.61
3rf4C-1l1lA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 11 ILE A 124
SER A 151
VAL A 122
PHE A 165
VAL A 163
 None
 1.27A 3rf4A-1l1lA:
0.1
3rf4B-1l1lA:
0.2		 3rf4A-1l1lA:
11.61
3rf4B-1l1lA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 11 ILE A 124
SER A 151
VAL A 122
PHE A 165
VAL A 163
 None
 1.25A 3rf4B-1l1lA:
0.2
3rf4C-1l1lA:
0.2		 3rf4B-1l1lA:
11.61
3rf4C-1l1lA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 12 ILE A 477
LEU A 481
ALA A 636
VAL A 489
VAL A 490
 None
 1.04A 3rukB-1l1lA:
undetectable		 3rukB-1l1lA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 8 GLY A 273
ALA A 314
SER A 272
TYR A 260
 None
 0.70A 3u9hA-1l1lA:
undetectable		 3u9hA-1l1lA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 8 GLY A 273
ALA A 314
SER A 272
TYR A 260
 None
 0.68A 3u9hB-1l1lA:
undetectable		 3u9hB-1l1lA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 8 PHE A 165
VAL A 167
ILE A 172
GLU A 322
 None
 1.05A 4a97C-1l1lA:
1.7		 4a97C-1l1lA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 8 GLY A 273
ALA A 314
SER A 272
TYR A 260
 None
 0.68A 4bjcA-1l1lA:
undetectable		 4bjcA-1l1lA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 LYS A  75
PRO A  70
LYS A   4
 None
 1.40A 4duzL-1l1lA:
0.0		 4duzL-1l1lA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 LYS A  75
PRO A  70
LYS A   4
 None
 1.36A 4dv7L-1l1lA:
undetectable		 4dv7L-1l1lA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 7 GLY A 273
ALA A 314
SER A 272
TYR A 260
 None
 0.68A 4hyfA-1l1lA:
undetectable		 4hyfA-1l1lA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 8 GLY A 273
ALA A 314
SER A 272
TYR A 260
 None
 0.66A 4hyfB-1l1lA:
undetectable		 4hyfB-1l1lA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 8 GLY A 273
ALA A 314
SER A 272
TYR A 260
 None
 0.73A 4hyfC-1l1lA:
undetectable		 4hyfC-1l1lA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 8 PRO A 508
VAL A 507
PRO A 499
ILE A 671
 None
 1.09A 4iilA-1l1lA:
undetectable		 4iilA-1l1lA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 9 PHE A 165
CYH A 305
PHE A 333
ILE A 172
 None
 1.32A 4jvlA-1l1lA:
0.0		 4jvlA-1l1lA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 5 ILE A 103
ARG A 224
ASP A 456
VAL A 450
 None
 1.19A 4nkxC-1l1lA:
0.0		 4nkxC-1l1lA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 5 ILE A 103
ARG A 224
ASP A 456
VAL A 450
 None
 1.16A 4nkxD-1l1lA:
0.0		 4nkxD-1l1lA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		3 / 3 MET A 275
MET A 158
TYR A 260
 None
 1.24A 4p6xI-1l1lA:
undetectable		 4p6xI-1l1lA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 12 LEU A 139
ASN A 415
LEU A 296
PHE A 239
ILE A 175
 None
 1.27A 5dv4A-1l1lA:
undetectable		 5dv4A-1l1lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 12 ALA A 441
LEU A  85
ILE A  89
TRP A 434
VAL A 424
 None
 1.40A 5vlmE-1l1lA:
0.0		 5vlmE-1l1lA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 12 VAL A 439
VAL A  19
GLY A  93
ALA A  94
LEU A 436
 None
 1.10A 5xxiA-1l1lA:
0.0		 5xxiA-1l1lA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 9 ALA A 298
GLY A 164
PHE A 165
SER A 353
GLY A 326
 None
 0.94A 6awoA-1l1lA:
0.0		 6awoA-1l1lA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 9 ALA A 298
GLY A 164
PHE A 165
SER A 353
GLY A 326
 None
 0.94A 6awqA-1l1lA:
0.0		 6awqA-1l1lA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		4 / 7 ALA A 615
LYS A 695
GLU A 699
LEU A 571
 None
 0.87A 6ci6A-1l1lA:
0.0		 6ci6A-1l1lA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE
(Lactobacillus
leichmannii) 		5 / 11 GLU A 423
SER A 648
THR A 650
THR A 652
ALA A 623
 None
 1.46A 6efnA-1l1lA:
3.1		 6efnA-1l1lA:
20.13