SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1l1o REPLICATION PROTEIN
A 70 KDA DNA-BINDING
SUBUNIT
(Homo
sapiens) 		3 / 3 ARG C 612
GLU C 601
SER C 613
 None
 0.94A 2xkkA-1l1oC:
undetectable
2xkkC-1l1oC:
undetectable		 2xkkA-1l1oC:
13.96
2xkkC-1l1oC:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
(Homo
sapiens) 		4 / 7 VAL B  91
LYS B  93
ILE B  94
GLY B  78
 None
 0.90A 3bjwB-1l1oB:
undetectable		 3bjwB-1l1oB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
(Homo
sapiens) 		5 / 9 ILE B  94
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.40A 3p4wA-1l1oB:
undetectable		 3p4wA-1l1oB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 1l1o REPLICATION PROTEIN
A 70 KDA DNA-BINDING
SUBUNIT
(Homo
sapiens) 		4 / 6 PHE C 570
PHE C 572
ALA C 536
LEU C 471
 None
 0.85A 4ejgD-1l1oC:
undetectable		 4ejgD-1l1oC:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1l1o REPLICATION PROTEIN
A 70 KDA DNA-BINDING
SUBUNIT
(Homo
sapiens) 		4 / 6 ALA C 536
GLN C 533
LEU C 516
LEU C 547
 None
 1.14A 4xoyA-1l1oC:
undetectable		 4xoyA-1l1oC:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1l1o REPLICATION PROTEIN
A 70 KDA DNA-BINDING
SUBUNIT
(Homo
sapiens) 		4 / 6 ALA C 536
GLN C 533
LEU C 516
LEU C 547
 None
 1.20A 4xp3A-1l1oC:
undetectable		 4xp3A-1l1oC:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
REPLICATION PROTEIN
A 70 KDA DNA-BINDING
SUBUNIT
(Homo
sapiens) 		3 / 3 VAL C 607
LEU B 149
MET B 152
 None
 0.66A 5ikrA-1l1oC:
0.0		 5ikrA-1l1oC:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
(Homo
sapiens) 		5 / 9 ILE B 146
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.44A 5mvnB-1l1oB:
undetectable		 5mvnB-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_C_PFLC407_1
(PROTON-GATED ION
CHANNEL)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
(Homo
sapiens) 		5 / 9 ILE B 146
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.44A 5mvnC-1l1oB:
0.0		 5mvnC-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 ILE B  94
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.36A 5mvnD-1l1oB:
undetectable		 5mvnD-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 ILE B 146
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.44A 5mvnD-1l1oB:
undetectable		 5mvnD-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 ILE B  94
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.33A 5mzrA-1l1oB:
0.0		 5mzrA-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 ILE B  94
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.33A 5mzrC-1l1oB:
0.0		 5mzrC-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
(Homo
sapiens) 		5 / 9 ILE B  94
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.36A 5mzrD-1l1oB:
0.0		 5mzrD-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 ILE B  90
VAL B 119
PRO B 122
 None
 0.70A 5uunA-1l1oB:
undetectable		 5uunA-1l1oB:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
REPLICATION PROTEIN
A 70 KDA DNA-BINDING
SUBUNIT
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER C 613
SER C 609
ALA B 165
 None
 0.71A 6dwnC-1l1oC:
undetectable		 6dwnC-1l1oC:
15.03