SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l1q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 8 VAL A  52
LEU A  75
VAL A  71
VAL A 177
 None
 0.99A 2bdmA-1l1qA:
undetectable		 2bdmA-1l1qA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 5 LEU A 174
GLY A 168
ILE A 137
ILE A 152
 None
 0.64A 2q9rA-1l1qA:
undetectable		 2q9rA-1l1qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		3 / 3 LEU A  67
ARG A  42
ILE A  66
 None
 0.68A 2xn5B-1l1qA:
undetectable		 2xn5B-1l1qA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 6 HIS A  48
VAL A   5
SER A 176
ILE A 152
 None
 0.76A 3kk6A-1l1qA:
undetectable		 3kk6A-1l1qA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 6 VAL A  41
LEU A 133
ILE A 158
LEU A  67
 None
 0.96A 3kk6A-1l1qA:
undetectable		 3kk6A-1l1qA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		5 / 8 LEU A  38
VAL A 177
LEU A 155
VAL A  45
ARG A  42
 None
 1.40A 3kp6A-1l1qA:
undetectable
3kp6B-1l1qA:
undetectable		 3kp6A-1l1qA:
25.38
3kp6B-1l1qA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		3 / 3 ARG A  83
LYS A  84
LYS A  87
 SO4  A 302 (-3.8A)
SO4  A 302 (-4.5A)
SO4  A 302 (-4.5A)
 1.12A 4k50A-1l1qA:
0.2		 4k50A-1l1qA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 6 GLU A 141
GLY A  64
ASP A 125
ARG A  63
 None
None
9DA  A 201 ( 4.6A)
SO4  A 301 (-2.9A)
 0.79A 5cdnA-1l1qA:
undetectable
5cdnB-1l1qA:
2.4		 5cdnA-1l1qA:
16.32
5cdnB-1l1qA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		5 / 12 MET A  99
THR A 132
LEU A 134
ALA A 135
GLU A 138
 None
SO4  A 301 (-3.7A)
None
None
None
 1.04A 5gs4A-1l1qA:
undetectable		 5gs4A-1l1qA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 8 LEU A  82
VAL A 120
LEU A 122
ILE A 150
 None
 0.64A 6cb4A-1l1qA:
undetectable		 6cb4A-1l1qA:
16.85