SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 ALA A  82
PHE A  74
ALA A  88
LEU A  91
LEU A  70
 None
 1.17A 2bxqA-1l2uA:
undetectable		 2bxqA-1l2uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 MET A  49
PHE A  57
ALA A  31
LEU A  30
 None
 1.08A 2o01A-1l2uA:
0.0		 2o01A-1l2uA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 8 LEU A  30
VAL A  58
LEU A  61
VAL A  45
LEU A  21
 None
 1.41A 3kp6A-1l2uA:
undetectable
3kp6B-1l2uA:
undetectable		 3kp6A-1l2uA:
22.63
3kp6B-1l2uA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 GLU A 152
GLU A 172
PHE A 180
ALA A 155
 None
 1.09A 3pgyA-1l2uA:
undetectable
3pgyB-1l2uA:
undetectable		 3pgyA-1l2uA:
21.90
3pgyB-1l2uA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 ARG A  64
ILE A  68
VAL A  45
LEU A  21
 None
 1.11A 4em2A-1l2uA:
0.0		 4em2A-1l2uA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 ASP A  34
ARG A  64
ASP A  27
 None
 0.78A 4fzvA-1l2uA:
undetectable		 4fzvA-1l2uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 VAL A 215
GLN A 171
CYH A 168
 None
 0.64A 5icxC-1l2uA:
undetectable
5icxF-1l2uA:
undetectable		 5icxC-1l2uA:
21.33
5icxF-1l2uA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 PHE A  57
GLU A  48
VAL A 219
THR A 225
GLY A 221
 None
 0.99A 5tuiB-1l2uA:
undetectable		 5tuiB-1l2uA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 ASP A  34
ARG A  64
ASP A  27
 None
 0.82A 5zvgA-1l2uA:
undetectable		 5zvgA-1l2uA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 ASP A  34
ARG A  64
ASP A  27
 None
 0.82A 5zvgB-1l2uA:
undetectable		 5zvgB-1l2uA:
21.15