SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l3i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.94A 1hpvA-1l3iA:
undetectable		 1hpvA-1l3iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 THR A  17
GLY A  46
GLY A  45
GLY A  43
MET A   1
 SAH  A 801 (-3.7A)
SAH  A 801 (-3.2A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
 1.22A 1wg8A-1l3iA:
18.7		 1wg8A-1l3iA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.90A 2avvD-1l3iA:
undetectable		 2avvD-1l3iA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 THR A  17
GLY A  41
GLY A  43
GLY A  46
ASP A  90
 SAH  A 801 (-3.7A)
SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-3.2A)
SAH  A 801 (-3.8A)
 0.60A 2b25A-1l3iA:
21.0		 2b25A-1l3iA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.89A 2f81A-1l3iA:
undetectable		 2f81A-1l3iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.89A 2f81B-1l3iA:
undetectable		 2f81B-1l3iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.85A 2f8gB-1l3iA:
undetectable		 2f8gB-1l3iA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 THR A  17
THR A  44
ASP A  62
ASP A  90
 SAH  A 801 (-3.7A)
SAH  A 801 (-4.1A)
SAH  A 801 (-2.6A)
SAH  A 801 (-3.8A)
 0.76A 2f8lA-1l3iA:
14.2		 2f8lA-1l3iA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.87A 2ienA-1l3iA:
undetectable		 2ienA-1l3iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 THR A  17
THR A  44
ASP A  62
ASP A  90
 SAH  A 801 (-3.7A)
SAH  A 801 (-4.1A)
SAH  A 801 (-2.6A)
SAH  A 801 (-3.8A)
 0.62A 2okcA-1l3iA:
12.7		 2okcA-1l3iA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 THR A  17
THR A  44
ASP A  62
ASP A  90
 SAH  A 801 (-3.7A)
SAH  A 801 (-4.1A)
SAH  A 801 (-2.6A)
SAH  A 801 (-3.8A)
 0.63A 2okcB-1l3iA:
12.8		 2okcB-1l3iA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 THR A  71
ALA A  52
LEU A  51
ASP A  39
VAL A  40
 None
 1.24A 2yvlC-1l3iA:
21.7		 2yvlC-1l3iA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.84A 3d20A-1l3iA:
undetectable		 3d20A-1l3iA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 GLY A  41
GLY A  43
ILE A  61
ASP A  90
ALA A  91
 SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
None
SAH  A 801 (-3.8A)
SAH  A 801 (-3.2A)
 0.44A 3dxyA-1l3iA:
13.6		 3dxyA-1l3iA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 8 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.91A 3ekpA-1l3iA:
undetectable		 3ekpA-1l3iA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.90A 3ektC-1l3iA:
undetectable		 3ektC-1l3iA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.88A 3ektD-1l3iA:
undetectable		 3ektD-1l3iA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A  40
GLY A  41
GLY A  43
ASP A  90
ALA A  91
 None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-3.8A)
SAH  A 801 (-3.2A)
 0.36A 3fuuA-1l3iA:
14.7		 3fuuA-1l3iA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.83A 3lzsB-1l3iA:
undetectable		 3lzsB-1l3iA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.86A 3lzuA-1l3iA:
undetectable		 3lzuA-1l3iA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.86A 3lzuB-1l3iA:
undetectable		 3lzuB-1l3iA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.94A 3ndtD-1l3iA:
undetectable		 3ndtD-1l3iA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.90A 3nduC-1l3iA:
undetectable		 3nduC-1l3iA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLY A  43
ASP A  62
ASP A  90
 SAH  A 801 (-3.2A)
SAH  A 801 (-2.6A)
SAH  A 801 (-3.8A)
 0.34A 3ou7C-1l3iA:
14.1		 3ou7C-1l3iA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.98A 3oxvC-1l3iA:
undetectable		 3oxvC-1l3iA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.90A 3pwmB-1l3iA:
undetectable		 3pwmB-1l3iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.87A 3pwrB-1l3iA:
undetectable		 3pwrB-1l3iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 THR A  17
GLY A  41
ASP A  62
ASN A  64
ASP A  90
 SAH  A 801 (-3.7A)
SAH  A 801 (-3.4A)
SAH  A 801 (-2.6A)
None
SAH  A 801 (-3.8A)
 1.02A 3q87B-1l3iA:
14.7		 3q87B-1l3iA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A  41
GLY A  43
THR A  44
ASP A  90
GLY A 107
 SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.8A)
SAH  A 801 (-4.6A)
 0.99A 3sglA-1l3iA:
5.1		 3sglA-1l3iA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A  41
GLY A  43
THR A  44
ASP A  90
GLY A 108
 SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.8A)
SAH  A 801 (-3.4A)
 0.76A 3sglA-1l3iA:
5.1		 3sglA-1l3iA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ILE A 131
ALA A  29
VAL A  55
ASP A  39
LEU A  51
 None
 1.16A 3ti1A-1l3iA:
undetectable		 3ti1A-1l3iA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.85A 3tkgD-1l3iA:
undetectable		 3tkgD-1l3iA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A  41
GLY A  45
GLY A  46
ASP A  62
ASP A  90
 SAH  A 801 (-3.4A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
SAH  A 801 (-2.6A)
SAH  A 801 (-3.8A)
 0.66A 4b17A-1l3iA:
12.9		 4b17A-1l3iA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.85A 4ll3B-1l3iA:
undetectable		 4ll3B-1l3iA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU A 136
GLY A 108
VAL A 179
GLY A  15
ILE A 135
 None
SAH  A 801 (-3.4A)
None
SAH  A 801 ( 3.8A)
None
 0.84A 4ll3A-1l3iA:
undetectable		 4ll3A-1l3iA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 THR A  17
GLY A  41
GLY A  43
GLY A  45
ALA A  91
 SAH  A 801 (-3.7A)
SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
 0.58A 4uciA-1l3iA:
8.4		 4uciA-1l3iA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 THR A  17
GLY A  41
GLY A  43
GLY A  45
ALA A  91
 SAH  A 801 (-3.7A)
SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
 0.57A 4uciB-1l3iA:
6.8		 4uciB-1l3iA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 THR A  17
GLY A  41
GLY A  43
GLY A  45
ALA A  91
 SAH  A 801 (-3.7A)
SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
 0.61A 4uckA-1l3iA:
7.6		 4uckA-1l3iA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 GLY A 107
VAL A  58
LEU A  75
LEU A  49
THR A  71
 SAH  A 801 (-4.6A)
None
None
None
None
 1.15A 4zmeA-1l3iA:
undetectable		 4zmeA-1l3iA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 PRO A  16
THR A  17
GLY A  43
GLY A  45
GLY A  46
 SAH  A 801 (-4.3A)
SAH  A 801 (-3.7A)
SAH  A 801 (-3.2A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
 0.76A 5c0oF-1l3iA:
19.7		 5c0oF-1l3iA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 PRO A  16
THR A  17
GLY A  41
GLY A  43
GLY A  46
 SAH  A 801 (-4.3A)
SAH  A 801 (-3.7A)
SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-3.2A)
 0.90A 5c0oG-1l3iA:
21.7		 5c0oG-1l3iA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 ASP A  39
GLY A  43
ASP A  62
ASP A  90
 None
SAH  A 801 (-3.2A)
SAH  A 801 (-2.6A)
SAH  A 801 (-3.8A)
 0.57A 5e72A-1l3iA:
19.4		 5e72A-1l3iA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 ASN A  83
VAL A  58
ALA A  60
GLY A  45
 None
None
None
SAH  A 801 (-4.0A)
 0.90A 5fpdB-1l3iA:
undetectable		 5fpdB-1l3iA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A  41
GLY A  43
ASN A  64
ALA A  67
ASP A  90
 SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
None
SAH  A 801 (-3.6A)
SAH  A 801 (-3.8A)
 0.56A 6b3aA-1l3iA:
9.4		 6b3aA-1l3iA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A  41
GLY A  43
ASN A  64
ALA A  67
ASP A  90
 SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
None
SAH  A 801 (-3.6A)
SAH  A 801 (-3.8A)
 0.61A 6b3bA-1l3iA:
8.7		 6b3bA-1l3iA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PRO A  16
ILE A   2
GLY A  46
GLU A  50
 SAH  A 801 (-4.3A)
None
SAH  A 801 (-3.2A)
None
 1.02A 6gqiA-1l3iA:
3.7		 6gqiA-1l3iA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ASP A  39
GLY A  41
GLY A  43
VAL A  47
ASP A  90
 None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.8A)
 0.90A 6nj9K-1l3iA:
11.8		 6nj9K-1l3iA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A  15
ASP A  39
GLY A  41
GLY A  43
ASP A  90
 SAH  A 801 ( 3.8A)
None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-3.8A)
 1.08A 6nj9K-1l3iA:
11.8		 6nj9K-1l3iA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 THR A  17
ASP A  39
GLY A  41
GLY A  43
VAL A  47
 SAH  A 801 (-3.7A)
None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-4.9A)
 0.75A 6nqaK-1l3iA:
10.4		 6nqaK-1l3iA:
19.14