SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 1l4a S-SNAP25 FUSION
PROTEIN
S-SYNTAXIN
SYNAPTOBREVIN
(Doryteuthis
pealeii) 		4 / 6 ASP A  73
ILE A  69
GLN C  56
GLU B 231
 ASP  A  73 ( 0.6A)
ILE  A  69 ( 0.7A)
GLN  C  56 ( 0.6A)
GLU  B 231 ( 0.5A)
 1.42A 2ya7C-1l4aA:
undetectable		 2ya7C-1l4aA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1l4a S-SNAP25 FUSION
PROTEIN
S-SNAP25 FUSION
PROTEIN
(Doryteuthis
pealeii;
Doryteuthis
pealeii) 		3 / 3 ASN C  37
ASN D 156
GLU D 159
 ASN  C  37 ( 0.6A)
ASN  D 156 ( 0.6A)
GLU  D 159 ( 0.6A)
 0.91A 3kpdB-1l4aC:
undetectable		 3kpdB-1l4aC:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 1l4a S-SNAP25 FUSION
PROTEIN
SYNAPTOBREVIN
(Doryteuthis
pealeii) 		4 / 5 LEU C  60
GLY C  57
ILE A  69
LYS A  68
 LEU  C  60 ( 0.6A)
GLY  C  57 ( 0.0A)
ILE  A  69 ( 0.7A)
LYS  A  68 ( 0.0A)
 1.11A 4ma8C-1l4aC:
undetectable		 4ma8C-1l4aC:
16.35