SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1l4i SFAE PROTEIN
(Escherichia
coli) 		5 / 12 PHE A  48
ILE A  50
VAL A  85
ALA A  21
VAL A   9
 None
 1.16A 2g72B-1l4iA:
undetectable		 2g72B-1l4iA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1l4i SFAE PROTEIN
(Escherichia
coli) 		3 / 3 LEU A 155
TYR A 188
GLN A 200
 None
 0.66A 2wekA-1l4iA:
undetectable		 2wekA-1l4iA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1l4i SFAE PROTEIN
(Escherichia
coli) 		4 / 5 VAL A  18
ILE A  50
MET A  57
ARG A   8
 None
 1.37A 3pyyB-1l4iA:
undetectable		 3pyyB-1l4iA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1l4i SFAE PROTEIN
(Escherichia
coli) 		4 / 5 GLN A 170
THR A 146
THR A 151
LEU A 114
 None
 1.35A 4lvcA-1l4iA:
undetectable		 4lvcA-1l4iA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1l4i SFAE PROTEIN
(Escherichia
coli) 		4 / 5 GLN A 170
THR A 146
THR A 151
LEU A 114
 None
 1.34A 4lvcC-1l4iA:
undetectable		 4lvcC-1l4iA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1l4i SFAE PROTEIN
(Escherichia
coli) 		4 / 4 GLN A 170
THR A 146
THR A 151
LEU A 114
 None
 1.36A 5m5kA-1l4iA:
undetectable		 5m5kA-1l4iA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1l4i SFAE PROTEIN
(Escherichia
coli) 		4 / 4 GLN A 170
THR A 146
THR A 151
LEU A 114
 None
 1.39A 5m5kC-1l4iA:
undetectable		 5m5kC-1l4iA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1l4i SFAE PROTEIN
(Escherichia
coli) 		4 / 4 GLN A 170
THR A 146
THR A 151
LEU A 114
 None
 1.37A 5m66B-1l4iA:
undetectable		 5m66B-1l4iA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1l4i SFAE PROTEIN
(Escherichia
coli) 		4 / 6 LEU A  20
VAL A  18
LEU A  82
GLU A  38
 None
 0.85A 5tudD-1l4iA:
undetectable		 5tudD-1l4iA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1l4i SFAE PROTEIN
(Escherichia
coli) 		4 / 6 VAL A  18
MET A 166
ARG A  79
PRO A 117
 None
 1.26A 6brdB-1l4iA:
0.0		 6brdB-1l4iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 1l4i SFAE PROTEIN
(Escherichia
coli) 		4 / 4 GLN A 170
THR A 146
THR A 151
LEU A 114
 None
 1.37A 6f3mB-1l4iA:
undetectable		 6f3mB-1l4iA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 1l4i SFAE PROTEIN
(Escherichia
coli) 		4 / 5 GLN A 170
THR A 146
THR A 151
LEU A 114
 None
 1.37A 6gbnA-1l4iA:
undetectable		 6gbnA-1l4iA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 1l4i SFAE PROTEIN
(Escherichia
coli) 		4 / 5 GLN A 170
THR A 146
THR A 151
LEU A 114
 None
 1.38A 6gbnD-1l4iA:
undetectable		 6gbnD-1l4iA:
16.55