SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 12 ILE A 302
ALA A 240
LEU A 241
LEU A 291
ALA A 286
 None
 1.07A 1g5yB-1l5aA:
undetectable		 1g5yB-1l5aA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		3 / 3 GLN A 318
TYR A 311
ARG A 310
 None
 0.91A 1gtbA-1l5aA:
0.1		 1gtbA-1l5aA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 11 ALA A 240
LEU A 241
LEU A 295
LEU A 419
ALA A 423
 None
 1.05A 1h9zA-1l5aA:
undetectable		 1h9zA-1l5aA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		4 / 6 TRP A 178
TYR A 171
ILE A 313
GLY A 309
 None
 1.13A 1maaB-1l5aA:
undetectable
1maaD-1l5aA:
undetectable		 1maaB-1l5aA:
22.32
1maaD-1l5aA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 10 PHE A  52
SER A  68
LEU A  42
PHE A 137
VAL A  46
 None
 1.44A 1q23E-1l5aA:
10.0		 1q23E-1l5aA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		3 / 3 TYR A 328
ARG A 189
GLN A 185
 None
 0.96A 1tw4A-1l5aA:
0.0		 1tw4A-1l5aA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 12 LEU A 244
LEU A 241
LEU A 238
ALA A 237
LEU A 419
 None
 1.16A 1ya3C-1l5aA:
undetectable		 1ya3C-1l5aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		4 / 5 LEU A 226
LEU A 219
LEU A 374
LEU A 404
 None
 1.12A 1yajD-1l5aA:
undetectable		 1yajD-1l5aA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		3 / 3 LEU A 279
PRO A 280
LEU A 305
 None
 0.60A 2po5B-1l5aA:
undetectable		 2po5B-1l5aA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		3 / 3 LEU A 279
PRO A 280
LEU A 305
 None
 0.57A 2po7B-1l5aA:
undetectable		 2po7B-1l5aA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		3 / 3 GLU A 360
ASP A 202
TYR A  15
 None
 0.79A 2yvlB-1l5aA:
undetectable		 2yvlB-1l5aA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 11 LEU A 419
ALA A 423
VAL A 415
LEU A 222
GLN A 297
 None
 1.31A 3bszE-1l5aA:
0.0		 3bszE-1l5aA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 11 PHE A 364
GLU A 250
HIS A 393
LEU A 256
SER A 331
 None
 1.28A 3o94A-1l5aA:
undetectable		 3o94A-1l5aA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 11 PHE A 364
GLU A 250
HIS A 393
LEU A 256
SER A 331
 None
 1.29A 3o94B-1l5aA:
0.0		 3o94B-1l5aA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 11 PHE A 364
GLU A 250
HIS A 393
LEU A 256
SER A 331
 None
 1.29A 3o94C-1l5aA:
undetectable		 3o94C-1l5aA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 11 PHE A 364
GLU A 250
HIS A 393
LEU A 256
SER A 331
 None
 1.28A 3o94D-1l5aA:
undetectable		 3o94D-1l5aA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		3 / 3 GLU A 314
LEU A   3
LEU A  62
 None
 0.58A 3ohtA-1l5aA:
undetectable		 3ohtA-1l5aA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		3 / 3 GLU A 314
LEU A   3
LEU A  62
 None
 0.58A 3ohtB-1l5aA:
undetectable		 3ohtB-1l5aA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 12 PRO A 254
PRO A 280
LEU A 279
ILE A 316
ALA A 191
 None
 1.37A 4a83A-1l5aA:
2.1		 4a83A-1l5aA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		4 / 5 SER A 174
GLU A 168
ASP A 180
ASN A 277
 None
 1.22A 4pclA-1l5aA:
0.0		 4pclA-1l5aA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		4 / 4 SER A 174
GLU A 168
GLU A 314
ASP A 180
 None
 1.33A 4pclB-1l5aA:
0.0		 4pclB-1l5aA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 10 ALA A 124
ILE A 105
GLY A 273
LEU A  51
ALA A  54
 None
 1.36A 5ajqB-1l5aA:
undetectable		 5ajqB-1l5aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		4 / 5 PHE A 158
HIS A 108
LEU A 141
PRO A 272
 None
 1.27A 5csyB-1l5aA:
undetectable		 5csyB-1l5aA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		4 / 5 LEU A 376
LEU A 219
PHE A 397
LEU A 241
 None
 1.04A 5gtrA-1l5aA:
0.0		 5gtrA-1l5aA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		5 / 12 PHE A 397
LEU A 404
LEU A 219
PHE A 366
ALA A 237
 None
 1.30A 5ieoA-1l5aA:
0.8		 5ieoA-1l5aA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		3 / 3 TYR A 161
SER A 163
TRP A  64
 None
 1.07A 5n8jB-1l5aA:
0.0		 5n8jB-1l5aA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		3 / 3 TYR A 161
SER A 163
TRP A  64
 None
 1.04A 5n8jA-1l5aA:
undetectable		 5n8jA-1l5aA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		3 / 3 LEU A 222
LEU A 223
TRP A 234
 None
 0.81A 5nwuA-1l5aA:
0.0		 5nwuA-1l5aA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		4 / 6 PHE A 366
ASN A 335
LEU A 337
GLY A 368
 None
 1.11A 5o4yA-1l5aA:
undetectable		 5o4yA-1l5aA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		4 / 4 LEU A  33
GLY A  31
SER A 116
SER A 114
 None
 1.18A 5uunB-1l5aA:
0.0		 5uunB-1l5aA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1l5a AMIDE SYNTHASE
(Vibrio
cholerae) 		4 / 8 LEU A   2
LEU A 129
GLY A 133
TYR A 161
 None
 0.91A 6ce2A-1l5aA:
undetectable		 6ce2A-1l5aA:
12.18