SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		4 / 7 ARG A 174
ASN A  93
TYR A 192
ASN A  97
 ACY  A 402 (-4.8A)
None
None
None
 1.29A 1f9gA-1l5xA:
undetectable		 1f9gA-1l5xA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 12 ALA A 122
ALA A 112
LEU A 239
SER A 106
ILE A 103
 None
 1.05A 1rg7A-1l5xA:
undetectable		 1rg7A-1l5xA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		4 / 8 LEU A 255
ASP A 251
THR A 152
TYR A 155
 None
 1.04A 1rmtD-1l5xA:
3.1		 1rmtD-1l5xA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 11 LEU A 237
GLY A 110
ALA A 112
GLY A  91
VAL A 167
 None
 0.88A 1t7jA-1l5xA:
undetectable		 1t7jA-1l5xA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		4 / 7 GLY A  42
SER A  67
SER A  36
GLU A  35
 None
 1.03A 2c8aB-1l5xA:
undetectable		 2c8aB-1l5xA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		4 / 7 GLY A  42
SER A  67
SER A  36
GLU A  35
 None
 0.98A 2c8aD-1l5xA:
undetectable		 2c8aD-1l5xA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 8 TYR A  54
GLY A  10
THR A  66
ALA A  65
ALA A  33
 None
 1.40A 2ej3C-1l5xA:
undetectable		 2ej3C-1l5xA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 11 ILE A 168
SER A 169
VAL A 185
LEU A 184
VAL A 259
 None
 1.02A 2kawA-1l5xA:
undetectable		 2kawA-1l5xA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		3 / 3 SER A 106
GLY A 107
THR A 108
 None
 0.12A 3k9wA-1l5xA:
3.4		 3k9wA-1l5xA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		4 / 8 ALA A 233
VAL A 226
LEU A 227
THR A  98
 None
 0.79A 3roxA-1l5xA:
3.0		 3roxA-1l5xA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		4 / 5 ASN A   7
ALA A  33
PRO A  34
ALA A 111
 None
 1.27A 3twpD-1l5xA:
2.6		 3twpD-1l5xA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 9 LEU A 237
GLY A 110
ALA A 112
GLY A  91
VAL A 167
 None
 0.84A 3u7sA-1l5xA:
undetectable		 3u7sA-1l5xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		4 / 7 THR A  73
ALA A 111
LEU A 109
SER A 106
 None
 0.91A 4d7bA-1l5xA:
undetectable		 4d7bA-1l5xA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 168
ALA A 122
LEU A 239
SER A 106
ILE A 103
 None
 1.07A 4dfrA-1l5xA:
undetectable		 4dfrA-1l5xA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 168
ALA A 122
LEU A 239
SER A 106
ILE A 103
 None
 1.10A 4gh8A-1l5xA:
undetectable		 4gh8A-1l5xA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 168
ALA A 122
LEU A 239
SER A 106
ILE A 103
 None
 1.08A 4gh8B-1l5xA:
undetectable		 4gh8B-1l5xA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		3 / 3 ASP A  86
LEU A  89
VAL A  32
 None
 0.68A 4jecB-1l5xA:
undetectable		 4jecB-1l5xA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		4 / 5 ARG A 257
TYR A 155
PRO A 162
VAL A 250
 None
None
None
ACY  A 401 (-4.3A)
 1.46A 4mjqA-1l5xA:
undetectable		 4mjqA-1l5xA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 168
ALA A 122
LEU A 239
SER A 106
ILE A 103
 None
 0.96A 4qi9A-1l5xA:
undetectable		 4qi9A-1l5xA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 168
ALA A 122
LEU A 239
SER A 106
ILE A 103
 None
 0.98A 4qi9B-1l5xA:
2.1		 4qi9B-1l5xA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 11 ILE A 168
ALA A 122
LEU A 239
SER A 106
ILE A 103
 None
 1.01A 4qleB-1l5xA:
undetectable		 4qleB-1l5xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 11 ALA A 122
PRO A 121
VAL A 156
THR A 152
ILE A 262
 None
 1.13A 4uuuB-1l5xA:
undetectable		 4uuuB-1l5xA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 7 ILE A   3
LEU A  19
TYR A 125
ALA A 153
ILE A  87
 None
 1.35A 4y03A-1l5xA:
undetectable		 4y03A-1l5xA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		4 / 5 LEU A  19
TYR A 125
ALA A 153
ILE A  87
 None
 0.94A 4y03B-1l5xA:
0.0		 4y03B-1l5xA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		4 / 7 GLY A  15
GLY A  91
SER A  90
ASP A   9
 None
 0.76A 5ergB-1l5xA:
2.2		 5ergB-1l5xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 168
ALA A 122
LEU A 239
SER A 106
ILE A 103
 None
 0.98A 5hi6A-1l5xA:
2.0		 5hi6A-1l5xA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		4 / 7 SER A 106
TYR A 192
SER A 169
ASN A  97
 None
 1.22A 5l1fC-1l5xA:
3.9		 5l1fC-1l5xA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1l5x SURVIVAL PROTEIN E
(Pyrobaculum
aerophilum) 		5 / 12 VAL A  74
ASP A 166
PRO A  70
GLY A  44
LEU A  43
 None
GOL  A 304 (-2.9A)
None
None
None
 1.15A 6b0lB-1l5xA:
3.0		 6b0lB-1l5xA:
16.36