SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 GLN A  77
HIS A 411
PRO A 102
 None
ZN  A 500 (-3.4A)
None
 0.88A 1d8cA-1l6jA:
undetectable		 1d8cA-1l6jA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 PHE A 107
TYR A  52
PRO A 102
 None
 1.15A 1mcnA-1l6jA:
undetectable
1mcnB-1l6jA:
undetectable
1mcnP-1l6jA:
undetectable		 1mcnA-1l6jA:
18.97
1mcnB-1l6jA:
18.97
1mcnP-1l6jA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.21A 1os2A-1l6jA:
24.4		 1os2A-1l6jA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.24A 1os2D-1l6jA:
24.4		 1os2D-1l6jA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 12 LEU A 132
PHE A 403
ALA A 144
ALA A 140
VAL A 217
 None
 1.38A 1rbpA-1l6jA:
undetectable		 1rbpA-1l6jA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.20A 1uttA-1l6jA:
24.8		 1uttA-1l6jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.20A 1utzA-1l6jA:
24.8		 1utzA-1l6jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.25A 1utzB-1l6jA:
24.8		 1utzB-1l6jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 6 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.24A 1y93A-1l6jA:
25.2		 1y93A-1l6jA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 7 GLY A 100
TYR A  52
GLU A 402
HIS A 401
 None
None
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.4A)
 1.13A 2ackA-1l6jA:
undetectable		 2ackA-1l6jA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.22A 2hu6A-1l6jA:
25.2		 2hu6A-1l6jA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 12 PHE A 192
PHE A 170
ILE A 137
ALA A 144
ALA A 406
 None
 1.19A 2j0dA-1l6jA:
undetectable		 2j0dA-1l6jA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		6 / 9 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
MET A 422
 None
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
None
 0.47A 2jihA-1l6jA:
9.2		 2jihA-1l6jA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 8 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 None
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.36A 2jihB-1l6jA:
9.3		 2jihB-1l6jA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 6 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.34A 2ow9A-1l6jA:
24.1		 2ow9A-1l6jA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 6 LEU A 187
HIS A 190
HIS A 401
GLU A 402
HIS A 411
 None
ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.4A)
 0.69A 2ow9A-1l6jA:
24.1		 2ow9A-1l6jA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.19A 2ow9B-1l6jA:
24.2		 2ow9B-1l6jA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.15A 2ozrC-1l6jA:
24.0		 2ozrC-1l6jA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.19A 2ozrD-1l6jA:
24.1		 2ozrD-1l6jA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.27A 2ozrE-1l6jA:
24.2		 2ozrE-1l6jA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 401
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.19A 2ozrF-1l6jA:
23.9		 2ozrF-1l6jA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 7 ILE A 166
LEU A 407
GLY A 404
PHE A 403
 None
 0.87A 2tsrA-1l6jA:
undetectable		 2tsrA-1l6jA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 190
GLU A 402
HIS A 405
 ZN  A 501 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
 0.52A 3ba0A-1l6jA:
22.1		 3ba0A-1l6jA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 9 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 None
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.38A 3hy7A-1l6jA:
9.4		 3hy7A-1l6jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 9 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 None
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.34A 3hy7B-1l6jA:
9.3		 3hy7B-1l6jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.15A 3kecA-1l6jA:
24.0		 3kecA-1l6jA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 401
GLU A 402
HIS A 405
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
 0.14A 3kecB-1l6jA:
24.0		 3kecB-1l6jA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.32A 3likA-1l6jA:
25.0		 3likA-1l6jA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.22A 3lilA-1l6jA:
25.0		 3lilA-1l6jA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.25A 3ljgA-1l6jA:
25.0		 3ljgA-1l6jA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.34A 3lkaA-1l6jA:
25.1		 3lkaA-1l6jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 6 GLN A  77
HIS A 405
HIS A 401
ASP A 103
 None
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
None
 1.25A 3nvcA-1l6jA:
undetectable		 3nvcA-1l6jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 6 GLN A 108
HIS A 203
HIS A 175
HIS A 190
 None
ZN  A 501 (-3.2A)
ZN  A 501 (-3.4A)
ZN  A 501 (-3.4A)
 0.90A 3nvcA-1l6jA:
undetectable		 3nvcA-1l6jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 12 GLY A 339
PRO A  32
GLY A  33
ASP A 390
MET A 338
 None
 1.46A 3r24A-1l6jA:
undetectable		 3r24A-1l6jA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 PHE A 204
PHE A 403
ALA A 400
LEU A 395
 None
 1.16A 3t3zC-1l6jA:
undetectable		 3t3zC-1l6jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 GLN A 108
PHE A 192
TYR A 179
 None
 0.87A 3ucjB-1l6jA:
undetectable		 3ucjB-1l6jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 GLN A 108
PHE A 192
TYR A 179
 None
 0.93A 3ucjA-1l6jA:
undetectable		 3ucjA-1l6jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 6 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.32A 4a7bA-1l6jA:
24.1		 4a7bA-1l6jA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 LEU A 187
HIS A 190
HIS A 401
GLU A 402
HIS A 405
 None
ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
 0.68A 4a7bB-1l6jA:
24.2		 4a7bB-1l6jA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 12 ILE A 166
ALA A 191
PHE A 403
LEU A 395
ILE A 168
 None
 0.95A 4m2xA-1l6jA:
undetectable		 4m2xA-1l6jA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 8 PHE A 425
VAL A 217
SER A 394
ALA A 229
 None
 0.91A 4m48A-1l6jA:
undetectable		 4m48A-1l6jA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 12 TYR A 262
ASP A 266
PHE A 236
TRP A 255
PHE A 268
 None
 1.23A 4nnrA-1l6jA:
undetectable
4nnrB-1l6jA:
undetectable		 4nnrA-1l6jA:
14.94
4nnrB-1l6jA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 10 TYR A 262
ASP A 266
PHE A 236
TRP A 255
PHE A 268
 None
 1.26A 4nnrB-1l6jA:
undetectable		 4nnrB-1l6jA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.24A 5n5jA-1l6jA:
25.2		 5n5jA-1l6jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.23A 5n5kA-1l6jA:
25.0		 5n5kA-1l6jA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
CYH A  99
HIS A 411
HIS A 405
 ZN  A 500 (-3.4A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.4A)
ZN  A 500 (-3.2A)
 1.44A 5zrdA-1l6jA:
undetectable		 5zrdA-1l6jA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 190
HIS A 175
HIS A 203
PHE A 192
 ZN  A 501 (-3.4A)
ZN  A 501 (-3.4A)
ZN  A 501 (-3.2A)
None
 1.23A 5zrdC-1l6jA:
undetectable		 5zrdC-1l6jA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 190
HIS A 175
HIS A 203
PHE A 192
 ZN  A 501 (-3.4A)
ZN  A 501 (-3.4A)
ZN  A 501 (-3.2A)
None
 1.24A 5zrdD-1l6jA:
undetectable		 5zrdD-1l6jA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 TYR A 179
HIS A 190
PHE A 192
 None
ZN  A 501 (-3.4A)
None
 0.32A 6esmA-1l6jA:
26.4		 6esmA-1l6jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 LEU A 147
GLY A 404
PHE A 204
 None
 0.65A 6exiC-1l6jA:
undetectable		 6exiC-1l6jA:
12.23