SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1l6n GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		3 / 3 THR A  81
LEU A  85
VAL A  88
 None
 0.61A 1mz9E-1l6nA:
undetectable		 1mz9E-1l6nA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1l6n GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		5 / 12 GLY A  56
CYH A  57
ILE A  34
LEU A   8
LEU A  78
 None
 1.25A 3cs8A-1l6nA:
0.0		 3cs8A-1l6nA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1l6n GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		4 / 7 VAL A  84
TRP A  16
HIS A  33
GLU A  17
 None
 1.41A 5ad9A-1l6nA:
undetectable
5ad9B-1l6nA:
undetectable		 5ad9A-1l6nA:
19.19
5ad9B-1l6nA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1l6n GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		4 / 8 LEU A 152
LEU A 188
ILE A 247
THR A 180
 None
 0.93A 5ljbA-1l6nA:
undetectable		 5ljbA-1l6nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1l6n GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		4 / 6 PRO A 149
THR A 151
ASN A 153
LYS A 157
 None
 0.99A 5xxiA-1l6nA:
0.6		 5xxiA-1l6nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1l6n GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		3 / 3 TRP A 249
ILE A 236
ASP A 235
 None
 0.80A 6i0y7-1l6nA:
undetectable		 6i0y7-1l6nA:
5.54