SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 12 ILE A 214
ILE A 217
ALA A 194
ILE A 198
PHE A 221
 None
 1.15A 1bsxA-1l6rA:
0.0		 1bsxA-1l6rA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 12 ILE A 214
ILE A 217
ALA A 194
ILE A 198
PHE A 221
 None
 1.15A 1bsxB-1l6rA:
0.0		 1bsxB-1l6rA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		4 / 7 PHE A 204
LEU A 170
ALA A   5
VAL A  38
 None
 0.87A 1epbA-1l6rA:
undetectable		 1epbA-1l6rA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		4 / 8 PHE A 204
LEU A 170
ALA A   5
VAL A  38
 None
 0.82A 1epbB-1l6rA:
undetectable		 1epbB-1l6rA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 10 LEU A  40
ILE A 217
GLY A 215
VAL A   9
ILE A   7
 None
 0.93A 1sdtA-1l6rA:
undetectable		 1sdtA-1l6rA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 12 LEU A  40
ALA A   5
ILE A 217
VAL A   9
ILE A   7
 None
 1.23A 2o4lA-1l6rA:
undetectable		 2o4lA-1l6rA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 12 SER A 141
GLY A 113
GLY A  64
GLY A  43
ILE A  46
 CA  A 904 ( 4.9A)
None
None
CA  A 904 ( 4.4A)
None
 0.89A 2wa2B-1l6rA:
undetectable		 2wa2B-1l6rA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 9 LEU A  40
ILE A 217
GLY A 215
VAL A   9
ILE A   7
 None
 0.98A 3d1yB-1l6rA:
undetectable		 3d1yB-1l6rA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 9 LEU A  13
VAL A  38
ILE A 172
LEU A 170
PHE A 218
 None
 1.39A 3fl9D-1l6rA:
undetectable		 3fl9D-1l6rA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 12 ALA A 110
ILE A  46
LEU A  52
GLY A  43
TYR A 140
 None
None
None
CA  A 904 ( 4.4A)
None
 1.15A 3k2hA-1l6rA:
1.9		 3k2hA-1l6rA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 12 ALA A 110
ILE A  46
LEU A  52
GLY A  43
TYR A 140
 None
None
None
CA  A 904 ( 4.4A)
None
 1.17A 3k2hB-1l6rA:
3.1		 3k2hB-1l6rA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		4 / 6 TYR A 208
VAL A  38
ILE A 172
ARG A  29
 None
 1.00A 3pyyA-1l6rA:
undetectable		 3pyyA-1l6rA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 9 ARG A   3
ALA A   6
VAL A 186
LEU A 184
ILE A 169
 None
 1.43A 3wsjA-1l6rA:
0.0		 3wsjA-1l6rA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 12 SER A 141
GLY A 113
GLY A  64
GLY A  43
ILE A  46
 CA  A 904 ( 4.9A)
None
None
CA  A 904 ( 4.4A)
None
 0.89A 4ctkC-1l6rA:
undetectable		 4ctkC-1l6rA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		4 / 6 ASP A   8
ASP A 174
ASN A 193
ASP A  10
 CA  A 901 (-3.1A)
CA  A 901 ( 3.2A)
CA  A 902 ( 4.3A)
CA  A 901 ( 4.7A)
 1.22A 4mdbA-1l6rA:
0.0		 4mdbA-1l6rA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 11 GLY A  64
LEU A  40
VAL A   9
TRP A 107
ILE A  46
 None
 1.26A 4pghC-1l6rA:
3.2		 4pghC-1l6rA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 10 LEU A  13
GLY A 211
ASN A 193
ASP A 174
SER A 209
 None
None
CA  A 902 ( 4.3A)
CA  A 901 ( 3.2A)
None
 1.15A 4xj7C-1l6rA:
3.5
4xj7D-1l6rA:
3.5		 4xj7C-1l6rA:
22.58
4xj7D-1l6rA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		4 / 8 ASP A 178
ASP A 174
ASP A   8
TYR A 140
 CA  A 901 (-2.4A)
CA  A 901 ( 3.2A)
CA  A 901 (-3.1A)
None
 0.99A 4xjeA-1l6rA:
3.1		 4xjeA-1l6rA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 12 SER A 141
GLY A 113
GLY A  64
GLY A  43
ILE A  46
 CA  A 904 ( 4.9A)
None
None
CA  A 904 ( 4.4A)
None
 0.87A 5ec8A-1l6rA:
undetectable		 5ec8A-1l6rA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 12 SER A 141
GLY A 113
GLY A  64
GLY A  43
ILE A  46
 CA  A 904 ( 4.9A)
None
None
CA  A 904 ( 4.4A)
None
 0.88A 5ekxA-1l6rA:
undetectable		 5ekxA-1l6rA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		4 / 7 VAL A  49
PHE A  71
ILE A  77
ASN A 146
 None
 1.00A 5hieC-1l6rA:
undetectable		 5hieC-1l6rA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1l6r HYPOTHETICAL PROTEIN
TA0175
(Thermoplasma
acidophilum) 		5 / 10 ILE A  58
ILE A  20
ALA A  24
ILE A  25
ILE A 214
 None
 1.05A 5mvmD-1l6rA:
0.0
5mvmE-1l6rA:
0.0		 5mvmD-1l6rA:
15.28
5mvmE-1l6rA:
15.28