SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l6w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 10 LEU A  93
VAL A 128
VAL A  86
GLY A 108
LEU A 119
 None
 1.24A 1fk9A-1l6wA:
undetectable		 1fk9A-1l6wA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		4 / 6 LEU A  56
PHE A  57
ALA A  58
LEU A  46
 None
 0.88A 1ukbA-1l6wA:
undetectable		 1ukbA-1l6wA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 10 LEU A  39
LEU A  43
ILE A  32
GLU A   2
LEU A  56
 None
 1.16A 1wopA-1l6wA:
0.0		 1wopA-1l6wA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 8 TYR A 131
GLY A 117
GLY A 108
THR A 109
ALA A 129
 GOL  A 250 (-4.0A)
None
None
GOL  A 250 ( 4.8A)
GOL  A 250 ( 4.1A)
 1.40A 2ej3C-1l6wA:
undetectable		 2ej3C-1l6wA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		4 / 5 PRO A 187
VAL A 190
THR A 145
GLY A 142
 None
 1.06A 3elzB-1l6wA:
undetectable		 3elzB-1l6wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 12 LEU A 149
GLY A 180
ALA A 179
ASP A 175
VAL A 146
 None
 1.05A 3gguA-1l6wA:
undetectable		 3gguA-1l6wA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 12 GLN A 138
VAL A 146
PHE A 167
ALA A 165
ALA A 164
 None
None
None
GOL  A 250 ( 2.9A)
None
 1.04A 3keeB-1l6wA:
undetectable		 3keeB-1l6wA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 12 ALA A 110
GLY A  92
ILE A  96
ARG A  76
VAL A  60
 None
 1.06A 3o7wA-1l6wA:
undetectable		 3o7wA-1l6wA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 11 GLY A 142
VAL A 146
SER A 141
ASP A 136
VAL A 132
 None
 1.21A 4d9hA-1l6wA:
undetectable		 4d9hA-1l6wA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 9 GLY A 142
VAL A 146
SER A 141
ASP A 136
VAL A 132
 None
 1.29A 4da6A-1l6wA:
undetectable		 4da6A-1l6wA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 11 GLY A 142
VAL A 146
SER A 141
ASP A 136
VAL A 132
 None
 1.19A 4danA-1l6wA:
undetectable		 4danA-1l6wA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 12 GLY A 142
VAL A 146
SER A 141
ASP A 136
VAL A 132
 None
 1.23A 4danA-1l6wA:
undetectable
4danB-1l6wA:
undetectable		 4danA-1l6wA:
21.85
4danB-1l6wA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		4 / 8 LEU A 149
LEU A 119
TYR A 112
GLN A  59
 None
 1.11A 5hbsA-1l6wA:
0.0		 5hbsA-1l6wA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 10 LEU A  93
VAL A 128
VAL A  86
GLY A 108
LEU A 119
 None
 1.29A 6bsgA-1l6wA:
undetectable		 6bsgA-1l6wA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1
(Escherichia
coli) 		5 / 10 LEU A  93
VAL A 128
VAL A  86
GLY A 108
LEU A 119
 None
 1.35A 6bsjA-1l6wA:
0.0		 6bsjA-1l6wA:
17.89