SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A   9
ALA A 152
LYS A 177
LEU A 159
ALA A 178
 None
 1.06A 1sn0A-1l7pA:
0.0
1sn0C-1l7pA:
undetectable		 1sn0A-1l7pA:
17.27
1sn0C-1l7pA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LYS A 177
LEU A 159
ALA A 178
LEU A   9
ALA A 152
 None
 0.99A 1sn5B-1l7pA:
0.0
1sn5D-1l7pA:
0.0		 1sn5B-1l7pA:
17.27
1sn5D-1l7pA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 203
LYS A 200
ILE A 182
PHE A 184
 None
 1.24A 2jn3A-1l7pA:
0.0		 2jn3A-1l7pA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  39
ASP A 171
SER A 173
 SEP  A 770 (-3.7A)
SEP  A 770 ( 4.7A)
None
 0.76A 2nxeA-1l7pA:
2.4		 2nxeA-1l7pA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  39
ASP A 171
SER A 173
 SEP  A 770 (-3.7A)
SEP  A 770 ( 4.7A)
None
 0.79A 2nxeB-1l7pA:
2.4		 2nxeB-1l7pA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  60
VAL A  57
PHE A 102
VAL A  68
 None
 1.05A 3soaA-1l7pA:
undetectable		 3soaA-1l7pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 187
PRO A 188
LYS A  40
 None
 1.46A 4dr5L-1l7pA:
0.0		 4dr5L-1l7pA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LYS A 153
ALA A 152
LEU A 148
LEU A   7
 None
 0.83A 4po0A-1l7pA:
undetectable		 4po0A-1l7pA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 105
GLY A 100
ALA A 120
ILE A 104
VAL A 134
 None
SEP  A 770 (-3.7A)
None
None
None
 1.03A 4r21B-1l7pA:
undetectable		 4r21B-1l7pA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 206
GLY A  80
LEU A 113
LEU A 115
 None
 0.80A 5hs1A-1l7pA:
undetectable		 5hs1A-1l7pA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1l7p PHOSPHOSERINE
PHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 167
LEU A   7
VAL A  94
ALA A 120
GLY A 101
 SEP  A 770 ( 4.4A)
None
None
None
SEP  A 770 ( 4.4A)
 1.11A 5uxdB-1l7pA:
undetectable		 5uxdB-1l7pA:
21.14