SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		5 / 8 LEU C 176
LEU C 172
PRO C 160
LEU C  78
ALA C  76
 None
 1.39A 2vcvF-1l7vC:
undetectable		 2vcvF-1l7vC:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		4 / 8 ALA C 113
VAL C 110
ASP C 109
LEU C 106
 None
 0.84A 3roxA-1l7vC:
undetectable		 3roxA-1l7vC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		5 / 12 LEU C  71
HIS C  99
GLY C 152
ASN C 149
ALA C  59
 None
 1.04A 3uwlB-1l7vC:
undetectable		 3uwlB-1l7vC:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		5 / 9 ALA C 148
LEU C  94
LEU C 106
ASN C 108
LEU C 142
 None
 1.44A 4x30A-1l7vC:
0.0		 4x30A-1l7vC:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		5 / 12 LEU C  29
LEU C 157
LEU C  43
LEU C  42
GLY C  48
 None
 1.06A 4xi3C-1l7vC:
undetectable		 4xi3C-1l7vC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		5 / 10 ALA C 113
VAL C 141
LEU C 157
LEU C 179
LEU C 176
 None
 1.19A 4zmeB-1l7vC:
0.0		 4zmeB-1l7vC:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		5 / 11 ASN C 108
LEU C 120
GLN C  98
ALA C 138
GLY C 112
 None
 1.32A 5cp3A-1l7vC:
0.0
5cp3H-1l7vC:
0.0		 5cp3A-1l7vC:
20.22
5cp3H-1l7vC:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		5 / 12 LEU C 106
LEU C 176
LEU C 172
ALA C  76
LEU C  78
 None
 1.16A 5iepA-1l7vC:
0.0		 5iepA-1l7vC:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		5 / 12 VAL C 135
VAL C 110
GLY C 112
ALA C 111
LEU C 120
 None
 1.10A 5iktA-1l7vC:
undetectable		 5iktA-1l7vC:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		5 / 9 LEU C  31
LEU C  29
ILE C  56
LEU C  16
MET C   5
 None
 1.33A 5og9A-1l7vC:
0.0		 5og9A-1l7vC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		5 / 12 MET C 188
LEU C 157
ILE C 144
PHE C  58
VAL C   4
 None
 1.04A 6djzA-1l7vC:
0.0		 6djzA-1l7vC:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD
(Escherichia
coli) 		5 / 10 ILE C  28
VAL C 140
LEU C 155
LEU C 179
LEU C 157
 None
 0.97A 6f6nA-1l7vC:
undetectable
6f6nB-1l7vC:
0.0		 6f6nA-1l7vC:
16.96
6f6nB-1l7vC:
15.73