SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		3 / 3 GLY A 127
GLY A 143
GLY A 148
 None
 0.31A 3bogC-1l8fA:
undetectable		 3bogC-1l8fA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		3 / 3 GLY A 127
GLY A 143
GLY A 148
 None
 0.30A 3bogD-1l8fA:
undetectable		 3bogD-1l8fA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		4 / 8 GLY A 148
PHE A 181
PHE A  93
PHE A 173
 None
 1.08A 3ko0D-1l8fA:
undetectable
3ko0E-1l8fA:
undetectable		 3ko0D-1l8fA:
18.60
3ko0E-1l8fA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		4 / 6 SER A 107
GLY A 115
ASP A 113
GLY A  78
 None
 1.01A 4koeA-1l8fA:
0.0
4koeB-1l8fA:
0.0
4koeC-1l8fA:
undetectable		 4koeA-1l8fA:
18.95
4koeB-1l8fA:
18.95
4koeC-1l8fA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		4 / 7 THR A 108
ALA A  73
THR A  74
ALA A  75
 None
 1.03A 4qw0K-1l8fA:
undetectable		 4qw0K-1l8fA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		4 / 7 THR A 108
ALA A  73
THR A  74
ALA A  75
 None
 1.03A 4qw0Y-1l8fA:
undetectable		 4qw0Y-1l8fA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		4 / 6 GLY A 115
ASP A 113
GLY A  78
SER A 107
 None
 1.04A 4z53A-1l8fA:
undetectable
4z53B-1l8fA:
undetectable		 4z53A-1l8fA:
14.15
4z53B-1l8fA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		5 / 10 VAL A 186
GLU A 184
PHE A 119
THR A 110
LEU A  76
 None
 1.38A 5mm4B-1l8fA:
undetectable		 5mm4B-1l8fA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		4 / 5 ASN A 175
ASP A 177
ASN A 178
ASP A 120
 None
 1.20A 5vooA-1l8fA:
undetectable		 5vooA-1l8fA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		4 / 5 ASN A 175
ASP A 177
ASN A 178
ASP A 120
 None
 1.21A 5vooC-1l8fA:
undetectable		 5vooC-1l8fA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		5 / 12 ASP A  10
GLY A 129
TYR A   8
ASN A 178
THR A   6
 None
 1.35A 5x7pB-1l8fA:
0.0		 5x7pB-1l8fA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1l8f ENDOGLUCANASE
(Melanocarpus
albomyces) 		3 / 3 PHE A  41
ARG A  19
GLN A  26
 None
 1.10A 6g1pB-1l8fA:
undetectable		 6g1pB-1l8fA:
16.57