SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1l8j ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 135
LEU A 151
VAL A 118
THR A 140
LEU A 148
 None
 1.18A 1jipA-1l8jA:
undetectable		 1jipA-1l8jA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1l8j ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 12 PHE A  19
SER A  17
TYR A  27
PHE A 114
VAL A 116
 None
None
None
PTY  A 200 ( 4.8A)
None
 1.35A 1q23C-1l8jA:
0.0		 1q23C-1l8jA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1l8j ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 11 PHE A  19
SER A  17
TYR A  27
PHE A 114
VAL A 116
 None
None
None
PTY  A 200 ( 4.8A)
None
 1.33A 1q23L-1l8jA:
0.0		 1q23L-1l8jA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 1l8j ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		3 / 3 THR A  48
PRO A  44
THR A  46
 None
 0.90A 316dC-1l8jA:
undetectable		 316dC-1l8jA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1l8j ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A  40
GLN A  66
GLY A  68
ARG A  64
 None
None
PTY  A 200 (-4.2A)
None
 1.06A 3bjwE-1l8jA:
undetectable		 3bjwE-1l8jA:
19.60