SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 ASN A  46
ASN A  70
ARG A 255
 None
 0.74A 2rlcA-1l8kA:
0.0		 2rlcA-1l8kA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 176
HIS A 157
HIS A 174
 None
 0.70A 3ag4A-1l8kA:
undetectable		 3ag4A-1l8kA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 176
HIS A 157
HIS A 174
 None
 0.72A 3ag4N-1l8kA:
undetectable		 3ag4N-1l8kA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		5 / 12 LEU A 249
ILE A 220
GLY A 257
ILE A 259
GLY A 221
 None
 0.93A 3bwcB-1l8kA:
undetectable		 3bwcB-1l8kA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		5 / 12 LEU A  85
GLY A 224
SER A 223
LEU A 112
LEU A 258
 None
 1.03A 3e23A-1l8kA:
undetectable		 3e23A-1l8kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 ASN A 243
ASN A 250
GLU A  78
 None
 0.90A 3kpdC-1l8kA:
0.0		 3kpdC-1l8kA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 ASN A 243
ASN A 250
GLU A  78
 None
 0.73A 3kpdB-1l8kA:
0.0		 3kpdB-1l8kA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		4 / 8 SER A 268
PHE A 195
LEU A 233
ASP A 230
 None
 1.04A 3m0wE-1l8kA:
undetectable
3m0wF-1l8kA:
undetectable
3m0wG-1l8kA:
undetectable
3m0wH-1l8kA:
undetectable		 3m0wE-1l8kA:
14.42
3m0wF-1l8kA:
14.42
3m0wG-1l8kA:
14.42
3m0wH-1l8kA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		5 / 12 PHE A  97
TYR A 126
GLN A 125
GLU A 119
ARG A  47
 None
 1.45A 4k38B-1l8kA:
0.0		 4k38B-1l8kA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		4 / 8 SER A 202
SER A 204
HIS A 209
ILE A 172
 None
 1.14A 4ms4A-1l8kA:
undetectable		 4ms4A-1l8kA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		4 / 6 LEU A 112
ASN A 113
LEU A  85
VAL A  51
 None
 0.97A 4okbA-1l8kA:
undetectable		 4okbA-1l8kA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		4 / 4 CYH A  94
PHE A  97
ILE A 115
GLY A  88
 None
 1.09A 5hesB-1l8kA:
0.0		 5hesB-1l8kA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		4 / 5 ARG A 255
CYH A 216
GLN A  87
ILE A 220
 None
 1.50A 5ki6A-1l8kA:
1.8		 5ki6A-1l8kA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens) 		4 / 8 GLY A 239
GLU A  78
ILE A 242
ASP A 241
 None
 0.96A 5vlmD-1l8kA:
0.0		 5vlmD-1l8kA:
19.81