SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l9g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 HIS A 107
ALA A 104
GLY A 106
GLU A 100
PRO A  22
 None
SF4  A 201 ( 4.2A)
None
None
None
 0.88A 1mj2A-1l9gA:
undetectable
1mj2B-1l9gA:
undetectable		 1mj2A-1l9gA:
17.59
1mj2B-1l9gA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 HIS A 107
ALA A 104
GLY A 106
GLU A 100
PRO A  22
 None
SF4  A 201 ( 4.2A)
None
None
None
 0.90A 1mj2C-1l9gA:
undetectable
1mj2D-1l9gA:
undetectable		 1mj2C-1l9gA:
17.59
1mj2D-1l9gA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 HIS A 107
ALA A 104
GLY A 106
GLU A 100
PRO A  22
 None
SF4  A 201 ( 4.2A)
None
None
None
 0.87A 1mjoC-1l9gA:
undetectable
1mjoD-1l9gA:
undetectable		 1mjoC-1l9gA:
17.59
1mjoD-1l9gA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 11 GLU A 100
PRO A  22
HIS A 107
ALA A 104
GLY A 106
 None
None
None
SF4  A 201 ( 4.2A)
None
 0.88A 1mjqA-1l9gA:
undetectable
1mjqB-1l9gA:
undetectable		 1mjqA-1l9gA:
17.59
1mjqB-1l9gA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 HIS A 107
ALA A 104
GLY A 106
GLU A 100
PRO A  22
 None
SF4  A 201 ( 4.2A)
None
None
None
 0.91A 1mjqC-1l9gA:
undetectable
1mjqD-1l9gA:
undetectable		 1mjqC-1l9gA:
17.59
1mjqD-1l9gA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 11 GLU A 100
PRO A  22
HIS A 107
ALA A 104
GLY A 106
 None
None
None
SF4  A 201 ( 4.2A)
None
 0.87A 1mjqI-1l9gA:
undetectable
1mjqJ-1l9gA:
undetectable		 1mjqI-1l9gA:
17.59
1mjqJ-1l9gA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 HIS A 107
ALA A 104
GLY A 106
GLU A 100
PRO A  22
 None
SF4  A 201 ( 4.2A)
None
None
None
 0.92A 1mjqI-1l9gA:
undetectable
1mjqJ-1l9gA:
undetectable		 1mjqI-1l9gA:
17.59
1mjqJ-1l9gA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 110
ILE A 116
VAL A  42
CYH A  84
VAL A  44
 None
 1.15A 2g72B-1l9gA:
undetectable		 2g72B-1l9gA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		3 / 3 ARG A  77
VAL A  42
THR A  39
 None
 0.85A 2nnkA-1l9gA:
undetectable		 2nnkA-1l9gA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 10 PHE A  59
ILE A 157
LEU A 166
ILE A 148
GLY A  45
 None
 1.28A 2v0mA-1l9gA:
undetectable		 2v0mA-1l9gA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A 166
ARG A  62
GLY A  61
ALA A  63
 None
 0.92A 2xfsA-1l9gA:
undetectable		 2xfsA-1l9gA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A 166
ARG A  62
GLY A  61
ALA A  63
 None
 0.91A 2xh9A-1l9gA:
undetectable		 2xh9A-1l9gA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 153
GLY A 152
PRO A 158
VAL A 138
LEU A 129
 None
 1.02A 3m6wA-1l9gA:
undetectable		 3m6wA-1l9gA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		3 / 3 ASP A 119
VAL A 122
ASN A 117
 None
 0.69A 4lmnA-1l9gA:
undetectable		 4lmnA-1l9gA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 8 GLY A  45
PHE A  59
ASN A  85
HIS A 161
 None
 0.55A 4wryA-1l9gA:
9.1		 4wryA-1l9gA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 8 GLY A  45
PHE A  59
ASN A  85
HIS A 161
 None
 0.48A 4wrzA-1l9gA:
9.1		 4wrzA-1l9gA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 7 GLY A  45
PHE A  59
ASN A  85
HIS A 161
 None
 0.47A 4ws0A-1l9gA:
8.7		 4ws0A-1l9gA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 8 GLY A  45
PHE A  59
ASN A  85
HIS A 161
 None
 0.48A 4ws1A-1l9gA:
10.1		 4ws1A-1l9gA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		3 / 3 GLY A  33
THR A  96
PRO A  48
 None
 0.63A 5v5zA-1l9gA:
0.0		 5v5zA-1l9gA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1l9g CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 GLU A  52
ASN A  85
GLY A  47
LEU A  71
GLY A  64
 None
 1.17A 5vooB-1l9gA:
undetectable		 5vooB-1l9gA:
19.93