SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		4 / 7 LEU A 247
GLU A 208
LEU A 193
LEU A 158
 None
 0.81A 1n13D-1l9xA:
undetectable
1n13E-1l9xA:
undetectable		 1n13D-1l9xA:
16.89
1n13E-1l9xA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		4 / 7 TYR A 226
GLU A  41
TYR A 291
TYR A 274
 None
 1.12A 3ku9B-1l9xA:
undetectable		 3ku9B-1l9xA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		4 / 5 GLU A 227
GLU A 222
PHE A 287
HIS A 171
 None
 1.44A 4a97J-1l9xA:
0.0		 4a97J-1l9xA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		4 / 6 SER A 176
THR A 197
ILE A 201
THR A 181
 None
 0.94A 4acbC-1l9xA:
2.9		 4acbC-1l9xA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		5 / 10 VAL A  47
ALA A  45
PHE A  63
LEU A  62
VAL A  48
 None
 1.40A 4eilB-1l9xA:
undetectable		 4eilB-1l9xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  47
ALA A  45
PHE A  63
LEU A  62
VAL A  48
 None
 1.49A 4kyaB-1l9xA:
undetectable		 4kyaB-1l9xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  47
ALA A  45
PHE A  63
LEU A  62
VAL A  48
 None
 1.48A 4kyaD-1l9xA:
undetectable		 4kyaD-1l9xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  47
ALA A  45
PHE A  63
LEU A  62
VAL A  48
 None
 1.48A 4kyaF-1l9xA:
undetectable		 4kyaF-1l9xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  47
ALA A  45
PHE A  63
LEU A  62
VAL A  48
 None
 1.47A 4kyaH-1l9xA:
undetectable		 4kyaH-1l9xA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		7 / 11 GLY A  73
GLY A  74
LEU A 111
GLU A 114
HIS A 171
TRP A 173
HIS A 220
 None
 0.41A 4l8fB-1l9xA:
47.8		 4l8fB-1l9xA:
53.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		7 / 11 GLY A  73
GLY A  74
LEU A 111
GLU A 114
HIS A 171
TRP A 173
HIS A 220
 None
 0.40A 4l8fD-1l9xA:
47.7		 4l8fD-1l9xA:
53.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8W_G_MTXG301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		6 / 9 GLY A  73
CYH A 110
LEU A 111
GLU A 114
HIS A 171
TRP A 173
 None
 0.55A 4l8wG-1l9xA:
47.5		 4l8wG-1l9xA:
53.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		6 / 9 GLY A  73
CYH A 110
LEU A 111
GLU A 114
HIS A 171
TRP A 173
 None
 0.49A 4l8wI-1l9xA:
47.7		 4l8wI-1l9xA:
53.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		4 / 7 PHE A 251
ILE A  12
PHE A 104
ASN A 258
 None
 1.19A 4o7gA-1l9xA:
undetectable
4o7gB-1l9xA:
undetectable		 4o7gA-1l9xA:
19.44
4o7gB-1l9xA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		4 / 6 PHE A 251
ILE A  12
PHE A 104
ASN A 258
 None
 1.25A 4o7gB-1l9xA:
undetectable		 4o7gB-1l9xA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		3 / 3 ASN A 183
PHE A 189
TYR A 210
 None
 0.90A 4u15A-1l9xA:
undetectable		 4u15A-1l9xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		5 / 12 SER A 205
THR A 195
ILE A 204
LEU A 157
PHE A 113
 None
 1.36A 6a93A-1l9xA:
undetectable		 6a93A-1l9xA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens) 		4 / 6 TYR A 274
ILE A 273
ALA A  45
ARG A  46
 None
 1.14A 6hu9m-1l9xA:
undetectable
6hu9q-1l9xA:
undetectable		 6hu9m-1l9xA:
18.53
6hu9q-1l9xA:
17.36