SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1l9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 12 GLY A 261
VAL A 217
MET A 266
SER A 115
HIS A 116
 None
None
None
None
ZN  A   1 (-3.4A)
 1.11A 1kiaA-1l9yA:
undetectable		 1kiaA-1l9yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 12 GLY A 261
VAL A 217
MET A 266
SER A 115
HIS A 116
 None
None
None
None
ZN  A   1 (-3.4A)
 1.10A 1kiaD-1l9yA:
undetectable		 1kiaD-1l9yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 12 GLY A 261
VAL A 217
MET A 266
SER A 115
HIS A 116
 None
None
None
None
ZN  A   1 (-3.4A)
 1.12A 1nbhA-1l9yA:
undetectable		 1nbhA-1l9yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 12 MET A 205
LEU A 207
PHE A 267
LEU A 260
PHE A  42
 None
 1.45A 1pj7A-1l9yA:
0.0		 1pj7A-1l9yA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		4 / 8 MET A 205
ALA A 189
LEU A 191
VAL A 180
 None
None
None
GOL  A 600 (-3.7A)
 0.70A 1sn5C-1l9yA:
undetectable		 1sn5C-1l9yA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 12 PHE A 165
ALA A  69
SER A  70
GLY A 220
GLY A 261
 None
 1.17A 2igtA-1l9yA:
undetectable		 2igtA-1l9yA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 12 MET A 139
ILE A 146
ASP A 142
THR A 197
ILE A 114
 None
 1.15A 2yzqA-1l9yA:
undetectable		 2yzqA-1l9yA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		4 / 6 HIS A 196
HIS A 263
SER A 262
ASP A 176
 ZN  A   1 ( 3.3A)
ZN  A   2 ( 3.3A)
None
None
 1.35A 4blvA-1l9yA:
undetectable		 4blvA-1l9yA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 10 HIS A 116
HIS A 118
ASP A 120
HIS A 196
HIS A 263
 ZN  A   1 (-3.4A)
ZN  A   1 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   1 ( 3.3A)
ZN  A   2 ( 3.3A)
 0.88A 4c1dB-1l9yA:
18.6		 4c1dB-1l9yA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 11 HIS A 116
HIS A 118
ASP A 120
HIS A 196
HIS A 263
 ZN  A   1 (-3.4A)
ZN  A   1 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   1 ( 3.3A)
ZN  A   2 ( 3.3A)
 0.92A 4c1fA-1l9yA:
19.0
4c1fB-1l9yA:
18.7		 4c1fA-1l9yA:
24.19
4c1fB-1l9yA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 9 HIS A 116
HIS A 118
ASP A 120
HIS A 196
HIS A 263
 ZN  A   1 (-3.4A)
ZN  A   1 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   1 ( 3.3A)
ZN  A   2 ( 3.3A)
 0.91A 4c1hA-1l9yA:
19.4		 4c1hA-1l9yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 9 HIS A 118
ASP A 120
HIS A 116
GLY A 223
HIS A 263
 ZN  A   1 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   1 (-3.4A)
None
ZN  A   2 ( 3.3A)
 0.86A 4c1hA-1l9yA:
19.4		 4c1hA-1l9yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		4 / 5 PHE A 154
ILE A 239
GLY A 195
THR A 197
 None
 1.04A 4ejjC-1l9yA:
undetectable		 4ejjC-1l9yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		4 / 8 HIS A 118
ASP A 120
HIS A 116
HIS A 263
 ZN  A   1 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   1 (-3.4A)
ZN  A   2 ( 3.3A)
 0.89A 4exsB-1l9yA:
17.8		 4exsB-1l9yA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		4 / 8 HIS A 118
ASP A 120
HIS A 196
HIS A 263
 ZN  A   1 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   1 ( 3.3A)
ZN  A   2 ( 3.3A)
 0.79A 4exsB-1l9yA:
17.8		 4exsB-1l9yA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		4 / 7 ASP A  86
LEU A 112
LYS A 110
LEU A  72
 None
 1.09A 4ib4A-1l9yA:
0.0		 4ib4A-1l9yA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 12 ILE A 219
GLY A 261
MET A 266
SER A 115
HIS A 116
 None
None
None
None
ZN  A   1 (-3.4A)
 1.02A 4iv0B-1l9yA:
undetectable		 4iv0B-1l9yA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 12 ILE A 219
GLY A 261
MET A 266
SER A 115
HIS A 116
 None
None
None
None
ZN  A   1 (-3.4A)
 1.02A 4mwzA-1l9yA:
undetectable		 4mwzA-1l9yA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		4 / 8 HIS A 118
ASP A 120
HIS A 196
HIS A 263
 ZN  A   1 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   1 ( 3.3A)
ZN  A   2 ( 3.3A)
 0.76A 5a5zA-1l9yA:
17.7		 5a5zA-1l9yA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		6 / 11 HIS A 116
HIS A 118
ASP A 120
HIS A 121
HIS A 196
HIS A 263
 ZN  A   1 (-3.4A)
ZN  A   1 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   2 (-3.3A)
ZN  A   1 ( 3.3A)
ZN  A   2 ( 3.3A)
 0.26A 5ayaA-1l9yA:
34.7		 5ayaA-1l9yA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		6 / 11 HIS A 116
HIS A 118
ASP A 120
HIS A 196
SER A 221
HIS A 263
 ZN  A   1 (-3.4A)
ZN  A   1 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   1 ( 3.3A)
None
ZN  A   2 ( 3.3A)
 0.77A 5ayaA-1l9yA:
34.7		 5ayaA-1l9yA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 12 PRO A  39
SER A  70
HIS A 116
LEU A  87
TYR A  36
 None
None
ZN  A   1 (-3.4A)
None
None
 1.38A 5eenB-1l9yA:
undetectable		 5eenB-1l9yA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 12 PRO A  37
HIS A 196
HIS A 263
ASP A 120
TYR A  36
 None
ZN  A   1 ( 3.3A)
ZN  A   2 ( 3.3A)
ZN  A   2 ( 2.6A)
None
 1.41A 5ef8B-1l9yA:
undetectable		 5ef8B-1l9yA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 12 PRO A  39
SER A  70
HIS A 116
LEU A  87
TYR A  36
 None
None
ZN  A   1 (-3.4A)
None
None
 1.41A 5ef8B-1l9yA:
undetectable		 5ef8B-1l9yA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		3 / 3 TYR A  36
TYR A 293
SER A 221
 None
 0.95A 5iktB-1l9yA:
0.0		 5iktB-1l9yA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		4 / 8 HIS A 118
ASP A 120
HIS A 116
HIS A 263
 ZN  A   1 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   1 (-3.4A)
ZN  A   2 ( 3.3A)
 0.85A 5zj8A-1l9yA:
17.3		 5zj8A-1l9yA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		4 / 8 HIS A 118
ASP A 120
HIS A 196
HIS A 263
 ZN  A   1 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   1 ( 3.3A)
ZN  A   2 ( 3.3A)
 0.86A 5zj8A-1l9yA:
17.3		 5zj8A-1l9yA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		5 / 10 GLY A 261
ASN A  84
ILE A 219
THR A 201
HIS A 116
 None
None
None
None
ZN  A   1 (-3.4A)
 1.10A 6e5zA-1l9yA:
undetectable		 6e5zA-1l9yA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1l9y FEZ-1 B-LACTAMASE
(Fluoribacter
gormanii) 		3 / 3 ALA A  97
PHE A 106
GLN A 131
 None
 0.79A 6eceA-1l9yA:
undetectable		 6eceA-1l9yA:
22.53