SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1la1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 1la1 GROEL
(Escherichia
coli) 		5 / 10 LEU A 222
VAL A 276
ILE A 325
PRO A 279
ILE A 250
 None
 0.99A 1hsgA-1la1A:
undetectable		 1hsgA-1la1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 1la1 GROEL
(Escherichia
coli) 		5 / 9 LEU A 222
VAL A 276
ILE A 325
PRO A 279
ILE A 250
 None
 1.00A 1ohrB-1la1A:
undetectable		 1ohrB-1la1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 1la1 GROEL
(Escherichia
coli) 		5 / 12 LEU A 247
LEU A 248
VAL A 254
LEU A 262
THR A 266
 None
 1.31A 2q7kA-1la1A:
undetectable		 2q7kA-1la1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1la1 GROEL
(Escherichia
coli) 		4 / 6 LEU A 221
ALA A 275
LEU A 262
ALA A 258
 None
 0.95A 2vcvB-1la1A:
0.0		 2vcvB-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1la1 GROEL
(Escherichia
coli) 		5 / 9 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
 None
 1.07A 2vcvD-1la1A:
undetectable		 2vcvD-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1la1 GROEL
(Escherichia
coli) 		5 / 9 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
 None
 1.06A 2vcvE-1la1A:
0.0		 2vcvE-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1la1 GROEL
(Escherichia
coli) 		4 / 7 LEU A 221
ALA A 275
LEU A 262
ALA A 258
 None
 0.89A 2vcvG-1la1A:
undetectable		 2vcvG-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1la1 GROEL
(Escherichia
coli) 		5 / 9 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
 None
 1.07A 2vcvH-1la1A:
undetectable		 2vcvH-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1la1 GROEL
(Escherichia
coli) 		5 / 9 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
 None
 1.02A 2vcvI-1la1A:
undetectable		 2vcvI-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1la1 GROEL
(Escherichia
coli) 		4 / 6 LEU A 221
ALA A 275
LEU A 262
ALA A 258
 None
 0.89A 2vcvK-1la1A:
undetectable		 2vcvK-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1la1 GROEL
(Escherichia
coli) 		4 / 5 VAL A 346
VAL A 369
ARG A 350
LYS A 188
 None
 1.26A 3rv5A-1la1A:
0.5
3rv5B-1la1A:
undetectable		 3rv5A-1la1A:
20.11
3rv5B-1la1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1la1 GROEL
(Escherichia
coli) 		5 / 9 PHE A 195
LEU A 248
VAL A 323
THR A 296
ILE A 332
 None
 1.13A 3tbgD-1la1A:
0.0		 3tbgD-1la1A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1la1 GROEL
(Escherichia
coli) 		5 / 10 ALA A 312
LEU A 309
ILE A 230
ALA A 258
ALA A 275
 None
 0.97A 4j14A-1la1A:
0.0		 4j14A-1la1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1la1 GROEL
(Escherichia
coli) 		5 / 12 ILE A 292
ALA A 278
LEU A 222
ALA A 223
VAL A 323
 None
 1.09A 4k6iA-1la1A:
undetectable		 4k6iA-1la1A:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1la1 GROEL
(Escherichia
coli) 		4 / 7 THR A 299
GLY A 297
ALA A 293
ILE A 342
 None
 0.64A 4yjiA-1la1A:
0.0		 4yjiA-1la1A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 1la1 GROEL
(Escherichia
coli) 		5 / 9 LEU A 222
VAL A 276
ILE A 325
PRO A 279
ILE A 250
 None
 1.09A 5kqxB-1la1A:
undetectable		 5kqxB-1la1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1la1 GROEL
(Escherichia
coli) 		4 / 5 LEU A 222
LEU A 221
MET A 307
GLN A 290
 None
 1.29A 5uc3A-1la1A:
undetectable		 5uc3A-1la1A:
18.28