SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1la2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 441
THR A 326
LEU A 328
ALA A 414
 None
 0.83A 1fiqC-1la2A:
undetectable		 1fiqC-1la2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 133
LEU A 134
PRO A 135
MET A 136
 None
 1.33A 1hz4A-1la2A:
undetectable		 1hz4A-1la2A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 321
ILE A  68
LEU A  70
VAL A  85
GLN A 111
 NAD  A 900 (-4.3A)
None
None
None
None
 0.98A 1tw4A-1la2A:
0.0		 1tw4A-1la2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 438
LEU A 445
LEU A 321
LEU A 441
 NAD  A 900 (-2.8A)
None
NAD  A 900 (-4.3A)
None
 1.27A 1u18A-1la2A:
0.0		 1u18A-1la2A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A  72
ASP A 148
ASN A  77
 NAD  A 900 (-3.3A)
NAD  A 900 (-3.0A)
NAD  A 900 (-2.9A)
 0.51A 1vq1A-1la2A:
undetectable		 1vq1A-1la2A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 219
ASP A 189
ASN A 194
 None
 0.78A 1wg8B-1la2A:
4.0		 1wg8B-1la2A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 258
ILE A 223
ILE A 185
THR A 279
LEU A 305
 None
 1.33A 2bjfA-1la2A:
0.0		 2bjfA-1la2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 510
LEU A 514
GLN A 111
MET A 136
LEU A 481
 None
 1.04A 2ft9A-1la2A:
0.0		 2ft9A-1la2A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 510
PRO A 444
GLN A 111
MET A 136
LEU A 481
 None
 1.10A 2ft9A-1la2A:
0.0		 2ft9A-1la2A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A  63
ALA A  87
LEU A  86
ALA A  83
ILE A  68
 None
 1.16A 2jjpA-1la2A:
undetectable		 2jjpA-1la2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  87
LEU A 164
THR A 443
LEU A  73
TYR A 105
 None
 1.14A 2oipB-1la2A:
undetectable		 2oipB-1la2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  87
LEU A 164
THR A 443
LEU A  73
TYR A 105
 None
 1.12A 2oipC-1la2A:
undetectable		 2oipC-1la2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  87
LEU A 164
THR A 443
LEU A  73
TYR A 105
 None
 1.13A 2oipD-1la2A:
undetectable		 2oipD-1la2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  87
LEU A 164
THR A 443
LEU A  73
TYR A 105
 None
 1.06A 2oipE-1la2A:
undetectable		 2oipE-1la2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 447
ILE A  68
LEU A 510
 None
 0.58A 2prgA-1la2A:
undetectable		 2prgA-1la2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  70
LEU A  73
PRO A  63
VAL A 144
PRO A 291
 None
 1.24A 3dcjA-1la2A:
3.6
3dcjB-1la2A:
undetectable		 3dcjA-1la2A:
18.65
3dcjB-1la2A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G59_A_ACTA306_0
(FMN
ADENYLYLTRANSFERASE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A 184
PHE A 281
ILE A 149
TRP A 243
 NAD  A 900 (-2.9A)
None
NAD  A 900 (-3.9A)
None
 1.27A 3g59A-1la2A:
1.4		 3g59A-1la2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  87
LEU A 164
THR A 443
LEU A  73
TYR A 105
 None
 1.13A 3hj3A-1la2A:
undetectable		 3hj3A-1la2A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  87
LEU A 164
THR A 443
LEU A  73
TYR A 105
 None
 1.15A 3hj3B-1la2A:
undetectable		 3hj3B-1la2A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  87
LEU A 164
THR A 443
LEU A  73
TYR A 105
 None
 1.10A 3hj3C-1la2A:
undetectable		 3hj3C-1la2A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  87
LEU A 164
THR A 443
LEU A  73
TYR A 105
 None
 1.11A 3hj3D-1la2A:
undetectable		 3hj3D-1la2A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A  84
LEU A  81
TYR A 105
LEU A 450
 None
 0.93A 3i45A-1la2A:
5.0		 3i45A-1la2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  81
LEU A  73
GLY A  72
GLY A  74
 None
None
NAD  A 900 (-3.3A)
NAD  A 900 (-4.0A)
 0.74A 3si7C-1la2A:
0.2
3si7D-1la2A:
0.2		 3si7C-1la2A:
19.63
3si7D-1la2A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  72
GLY A  74
ASP A 148
ALA A 245
ASN A 246
 NAD  A 900 (-3.3A)
NAD  A 900 (-4.0A)
NAD  A 900 (-3.0A)
NAD  A 900 (-3.5A)
NAD  A 900 (-3.8A)
 1.32A 3t7sA-1la2A:
undetectable		 3t7sA-1la2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  72
GLY A  74
ASP A 148
ALA A 245
ASN A 246
 NAD  A 900 (-3.3A)
NAD  A 900 (-4.0A)
NAD  A 900 (-3.0A)
NAD  A 900 (-3.5A)
NAD  A 900 (-3.8A)
 1.33A 3t7sB-1la2A:
undetectable		 3t7sB-1la2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  72
GLY A  74
ASP A 148
ALA A 245
ASN A 246
 NAD  A 900 (-3.3A)
NAD  A 900 (-4.0A)
NAD  A 900 (-3.0A)
NAD  A 900 (-3.5A)
NAD  A 900 (-3.8A)
 1.34A 3t7sD-1la2A:
undetectable		 3t7sD-1la2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 303
GLY A 304
LEU A 264
ASN A 263
 None
 0.96A 3zqtA-1la2A:
undetectable		 3zqtA-1la2A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 185
ILE A 275
TYR A 187
GLU A 273
 None
 1.06A 4a99D-1la2A:
3.2		 4a99D-1la2A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 516
LYS A  18
TYR A  32
TYR A  54
 None
 1.13A 4b3qA-1la2A:
0.0		 4b3qA-1la2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 222
ARG A 225
ILE A 203
 None
 0.88A 4b7qA-1la2A:
undetectable		 4b7qA-1la2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 222
ARG A 225
ILE A 203
 None
 0.80A 4b7qC-1la2A:
undetectable		 4b7qC-1la2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  77
ASP A 148
GLY A  74
GLY A  75
ILE A 149
 NAD  A 900 (-2.9A)
NAD  A 900 (-3.0A)
NAD  A 900 (-4.0A)
NAD  A 900 (-3.2A)
NAD  A 900 (-3.9A)
 1.01A 4jkuA-1la2A:
3.4		 4jkuA-1la2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  77
ASP A 148
GLY A  74
GLY A  75
ILE A 149
 NAD  A 900 (-2.9A)
NAD  A 900 (-3.0A)
NAD  A 900 (-4.0A)
NAD  A 900 (-3.2A)
NAD  A 900 (-3.9A)
 1.01A 4k8cA-1la2A:
3.3		 4k8cA-1la2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  77
ASP A 148
GLY A  74
GLY A  75
ILE A 149
 NAD  A 900 (-2.9A)
NAD  A 900 (-3.0A)
NAD  A 900 (-4.0A)
NAD  A 900 (-3.2A)
NAD  A 900 (-3.9A)
 1.00A 4kalA-1la2A:
3.3		 4kalA-1la2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  77
ASP A 148
GLY A  74
GLY A  75
ILE A 149
 NAD  A 900 (-2.9A)
NAD  A 900 (-3.0A)
NAD  A 900 (-4.0A)
NAD  A 900 (-3.2A)
NAD  A 900 (-3.9A)
 1.01A 4kalB-1la2A:
3.2		 4kalB-1la2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 161
ASN A  76
ASN A 355
ASN A 200
ASN A 151
 None
NAD  A 900 (-3.3A)
NAD  A 900 (-4.0A)
None
None
 1.47A 4kuoA-1la2A:
undetectable		 4kuoA-1la2A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 148
ASN A 150
ALA A 199
TYR A 186
 NAD  A 900 (-3.0A)
None
None
None
 1.18A 4mdaA-1la2A:
0.0		 4mdaA-1la2A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 318
ILE A 293
LEU A 488
LEU A 321
 None
None
None
NAD  A 900 (-4.3A)
 0.70A 4mwzB-1la2A:
0.0		 4mwzB-1la2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 CYH A 202
ILE A 185
LEU A 205
HIS A 219
 None
 0.71A 5hrqC-1la2A:
undetectable
5hrqD-1la2A:
undetectable
5hrqL-1la2A:
undetectable		 5hrqC-1la2A:
3.71
5hrqD-1la2A:
7.10
5hrqL-1la2A:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 CYH A 202
ILE A 185
LEU A 205
HIS A 219
 None
 0.71A 5hrqE-1la2A:
undetectable
5hrqF-1la2A:
undetectable
5hrqJ-1la2A:
undetectable		 5hrqE-1la2A:
3.71
5hrqF-1la2A:
7.10
5hrqJ-1la2A:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 9 ILE A  68
PHE A 142
THR A 244
ILE A 446
 None
None
NAD  A 900 (-4.6A)
None
 0.88A 5lg3I-1la2A:
0.0		 5lg3I-1la2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  68
PHE A 142
THR A 244
ASN A 294
ILE A 446
 None
None
NAD  A 900 (-4.6A)
None
None
 1.04A 5lg3J-1la2A:
0.1		 5lg3J-1la2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 343
ILE A 381
ILE A 380
TYR A 418
ILE A 346
 None
 1.39A 5mzrA-1la2A:
0.0		 5mzrA-1la2A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 343
ILE A 381
ILE A 380
TYR A 418
ILE A 346
 None
 1.38A 5mzrC-1la2A:
0.0		 5mzrC-1la2A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A  81
THR A  80
ILE A 446
LEU A  73
ASN A  76
LEU A 321
 None
None
None
None
NAD  A 900 (-3.3A)
NAD  A 900 (-4.3A)
 1.45A 5nfjA-1la2A:
2.8		 5nfjA-1la2A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 434
SER A 348
ALA A 414
VAL A 413
 None
 1.20A 5nm5A-1la2A:
1.3		 5nm5A-1la2A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  81
ALA A  83
LEU A  86
LEU A 164
 None
 0.70A 5vkqA-1la2A:
0.0
5vkqD-1la2A:
0.0		 5vkqA-1la2A:
15.58
5vkqD-1la2A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 164
LEU A  81
ALA A  83
LEU A  86
 None
 0.72A 5vkqA-1la2A:
0.0
5vkqB-1la2A:
0.0		 5vkqA-1la2A:
15.58
5vkqB-1la2A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 164
LEU A  81
ALA A  83
LEU A  86
 None
 0.69A 5vkqB-1la2A:
0.0
5vkqC-1la2A:
0.0		 5vkqB-1la2A:
15.58
5vkqC-1la2A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 164
LEU A  81
ALA A  83
LEU A  86
 None
 0.74A 5vkqC-1la2A:
0.0
5vkqD-1la2A:
0.0		 5vkqC-1la2A:
15.58
5vkqD-1la2A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  72
GLY A  74
ASP A 148
ILE A 149
ASN A 150
 NAD  A 900 (-3.3A)
NAD  A 900 (-4.0A)
NAD  A 900 (-3.0A)
NAD  A 900 (-3.9A)
None
 0.53A 5wy0A-1la2A:
3.0		 5wy0A-1la2A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 501
VAL A 396
HIS A 398
 None
 0.84A 6a5yD-1la2A:
undetectable		 6a5yD-1la2A:
8.99