SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 PHE A 183
ALA A 300
ALA A 277
VAL A 248
LEU A 166
 None
 1.24A 1cbrA-1lamA:
undetectable		 1cbrA-1lamA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 PHE A 183
ALA A 300
ALA A 277
VAL A 248
LEU A 166
 None
 1.24A 1cbrB-1lamA:
undetectable		 1cbrB-1lamA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 6 VAL A 248
GLY A 249
ALA A 342
LEU A 343
 None
 0.75A 1e7bB-1lamA:
0.0		 1e7bB-1lamA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 6 HIS A 233
ILE A 232
ALA A 194
VAL A 187
 MRD  A 503 (-4.0A)
None
None
None
 0.94A 1hk1A-1lamA:
undetectable		 1hk1A-1lamA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 6 HIS A 233
ILE A 232
ALA A 283
VAL A 187
 MRD  A 503 (-4.0A)
None
None
None
 0.99A 1hk1A-1lamA:
undetectable		 1hk1A-1lamA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 8 VAL A 246
VAL A 248
ILE A 338
LEU A 343
 None
 0.78A 1igxA-1lamA:
0.0		 1igxA-1lamA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 7 PHE A 435
ALA A 340
PHE A 439
SER A 215
 None
 1.20A 1lqtA-1lamA:
2.6		 1lqtA-1lamA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 7 PHE A 435
ALA A 340
PHE A 439
SER A 215
 None
 1.20A 1lquA-1lamA:
2.2		 1lquA-1lamA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 8 ASN A 165
LEU A 125
GLY A 122
GLY A 157
 None
 0.85A 1rukH-1lamA:
undetectable
1rukL-1lamA:
undetectable		 1rukH-1lamA:
19.21
1rukL-1lamA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		3 / 3 THR A 474
THR A 472
PRO A 471
 None
 0.87A 209dC-1lamA:
undetectable		 209dC-1lamA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 LEU A 299
VAL A 248
GLY A 249
GLY A 251
ALA A 342
 None
 0.88A 2egvA-1lamA:
undetectable		 2egvA-1lamA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 LEU A 299
VAL A 248
GLY A 249
GLY A 251
ALA A 342
 None
 0.91A 2egvB-1lamA:
undetectable		 2egvB-1lamA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 7 LEU A  57
PHE A  61
PHE A  27
LEU A  35
 None
 1.04A 2eimP-1lamA:
undetectable
2eimW-1lamA:
undetectable		 2eimP-1lamA:
19.35
2eimW-1lamA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 GLY A 469
ALA A 278
GLY A 276
ALA A 357
LEU A 170
 None
 1.03A 2nyuA-1lamA:
undetectable		 2nyuA-1lamA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 8 LEU A 170
ALA A 277
GLY A 298
ILE A 232
LEU A 166
 None
 1.29A 2o4nB-1lamA:
undetectable		 2o4nB-1lamA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 ILE A 338
THR A 361
ALA A 358
ILE A 421
LEU A 436
 None
 1.04A 2rlcA-1lamA:
0.0		 2rlcA-1lamA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 8 ALA A 123
ALA A 119
GLY A   7
ALA A  92
 None
 0.91A 2vh3B-1lamA:
undetectable		 2vh3B-1lamA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 9 PHE A 183
ALA A 184
VAL A 187
GLU A 188
 None
 0.21A 2vufA-1lamA:
0.0		 2vufA-1lamA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		3 / 3 THR A 472
PRO A 471
THR A 474
 None
 0.76A 316dC-1lamA:
undetectable		 316dC-1lamA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 8 ILE A 284
LEU A 230
VAL A 200
GLY A 298
 None
 0.83A 3dcjB-1lamA:
undetectable		 3dcjB-1lamA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 GLY A 362
ASP A 449
VAL A 410
ALA A 433
ALA A 434
 None
 0.99A 3keeB-1lamA:
undetectable		 3keeB-1lamA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 GLY A 362
ASP A 449
VAL A 410
ALA A 433
ALA A 434
 None
 1.01A 3keeC-1lamA:
undetectable		 3keeC-1lamA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 GLY A 276
ASP A 449
GLY A 335
ILE A 338
ALA A 300
 None
None
CO3  A 500 ( 3.2A)
None
None
 0.84A 3n3iA-1lamA:
undetectable		 3n3iA-1lamA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 10 LEU A 436
ALA A 342
GLY A 298
ILE A 280
LEU A 343
 None
 1.06A 3ogpA-1lamA:
undetectable		 3ogpA-1lamA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 5 ASN A 312
ASP A 255
THR A 361
SER A 218
 None
ZN  A 488 (-2.5A)
None
None
 1.47A 3p2kC-1lamA:
undetectable		 3p2kC-1lamA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 6 GLY A 276
GLY A 275
MET A 171
ILE A 450
 None
 0.90A 4fglD-1lamA:
undetectable		 4fglD-1lamA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 ALA A 340
PHE A 439
ARG A 319
GLY A 214
VAL A 328
 None
 1.13A 4nkvA-1lamA:
0.0		 4nkvA-1lamA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		6 / 12 GLY A 249
GLY A 251
LEU A 302
MET A 178
LEU A 170
GLY A 275
 None
 1.31A 4o33A-1lamA:
undetectable		 4o33A-1lamA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 VAL A 353
HIS A 347
LEU A 339
ALA A 446
ASN A 378
 None
 1.50A 4qdcA-1lamA:
0.0		 4qdcA-1lamA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 7 ASN A  81
GLU A  80
GLU A  84
GLU A  78
 None
 1.15A 4r87I-1lamA:
0.0		 4r87I-1lamA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		3 / 3 VAL A 228
ALA A 300
PHE A 216
 None
 0.92A 4w5nA-1lamA:
2.3		 4w5nA-1lamA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 7 VAL A 410
ILE A 326
HIS A 447
LEU A 360
 None
None
None
CO3  A 500 ( 4.0A)
 1.14A 4xo7B-1lamA:
undetectable		 4xo7B-1lamA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		3 / 3 ASP A 332
ASN A 312
PHE A 216
 ZN  A 488 ( 2.9A)
None
None
 0.74A 5dsgB-1lamA:
0.0		 5dsgB-1lamA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 GLY A 469
ILE A 450
ASN A 165
ARG A 168
ASN A 190
 None
 1.14A 5fa8A-1lamA:
undetectable		 5fa8A-1lamA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 ALA A 167
GLY A 469
GLY A 275
GLY A 163
SER A 282
 None
 1.11A 5gwxA-1lamA:
undetectable		 5gwxA-1lamA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 10 PRO A  18
ILE A  89
PRO A 112
ALA A 119
VAL A  67
 None
 1.38A 5m0oA-1lamA:
undetectable		 5m0oA-1lamA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		3 / 3 SER A 215
SER A 218
PHE A 435
 None
 0.92A 5mugA-1lamA:
undetectable		 5mugA-1lamA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 12 ILE A 208
PHE A 349
ILE A 284
LEU A 299
ALA A 346
 None
 1.12A 5oy02-1lamA:
undetectable		 5oy02-1lamA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		3 / 3 ASP A 329
ASN A 419
ASP A 412
 None
 0.85A 5vopA-1lamA:
3.1		 5vopA-1lamA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 6 LEU A  57
PHE A  61
PHE A  27
LEU A  35
 None
 1.07A 5x19P-1lamA:
0.0		 5x19P-1lamA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 5 LEU A  57
PHE A  61
PHE A  27
LEU A  35
 None
 1.10A 5x1bP-1lamA:
0.0		 5x1bP-1lamA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		5 / 10 LEU A 343
ILE A 355
LEU A 448
ALA A 433
LEU A 402
 None
 1.24A 5y7pG-1lamA:
0.0		 5y7pG-1lamA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1lam LEUCINE
AMINOPEPTIDASE
(Bos
taurus) 		4 / 8 ARG A  98
VAL A 108
ARG A 168
GLN A 164
 None
 1.22A 6fbvD-1lamA:
0.0		 6fbvD-1lamA:
17.10