SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lar'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 7 THR A1461
GLY A1676
THR A1847
ILE A1828
 None
 0.88A 1gtnC-1larA:
undetectable
1gtnD-1larA:
undetectable		 1gtnC-1larA:
9.07
1gtnD-1larA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 6 THR A1461
GLY A1676
THR A1847
ILE A1828
 None
 0.88A 1gtnD-1larA:
0.0
1gtnE-1larA:
0.1		 1gtnD-1larA:
9.07
1gtnE-1larA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 7 THR A1461
GLY A1676
THR A1847
ILE A1828
 None
 0.88A 1gtnF-1larA:
0.0
1gtnG-1larA:
0.1		 1gtnF-1larA:
9.07
1gtnG-1larA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 7 THR A1461
GLY A1676
THR A1847
ILE A1828
 None
 0.88A 1gtnJ-1larA:
0.1
1gtnK-1larA:
0.0		 1gtnJ-1larA:
9.07
1gtnK-1larA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		5 / 12 HIS A1586
LEU A1578
ALA A1581
LEU A1501
PRO A1497
 None
 1.09A 1mjqC-1larA:
undetectable
1mjqD-1larA:
undetectable		 1mjqC-1larA:
9.98
1mjqD-1larA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		5 / 10 ARG A1481
GLU A1479
ALA A1468
LEU A1454
GLY A1442
 None
 1.23A 1mjqG-1larA:
undetectable
1mjqH-1larA:
undetectable		 1mjqG-1larA:
9.98
1mjqH-1larA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		5 / 12 HIS A1586
LEU A1578
ALA A1581
LEU A1501
PRO A1497
 None
 1.10A 1mjqI-1larA:
undetectable
1mjqJ-1larA:
undetectable		 1mjqI-1larA:
9.98
1mjqJ-1larA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 8 SER A1344
LEU A1368
ASP A1378
GLU A1414
 None
 1.14A 1mxgA-1larA:
undetectable		 1mxgA-1larA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		3 / 3 ASP A1667
TYR A1668
GLU A1651
 None
 0.85A 1vm1A-1larA:
undetectable		 1vm1A-1larA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 7 TYR A1355
VAL A1526
GLY A1527
THR A1567
 None
 0.82A 2a1mA-1larA:
undetectable		 2a1mA-1larA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		3 / 3 ARG A1505
VAL A1829
THR A1844
 None
 0.81A 2nnkA-1larA:
undetectable		 2nnkA-1larA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 8 SER A1814
VAL A1782
GLY A1781
TRP A1777
 None
 0.81A 2qd3A-1larA:
2.0		 2qd3A-1larA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		3 / 3 ASN A1353
ASN A1381
ARG A1561
 None
 0.73A 2rlcA-1larA:
0.0		 2rlcA-1larA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		3 / 3 ASN A1642
ASN A1670
ARG A1852
 None
 0.72A 2rlcA-1larA:
0.0		 2rlcA-1larA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		3 / 3 ARG A1365
ASP A1407
ASN A1349
 None
 0.79A 2zzmA-1larA:
undetectable		 2zzmA-1larA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		5 / 12 SER A1370
ASP A1378
LYS A1352
VAL A1348
LEU A1346
 None
 1.44A 3cb8A-1larA:
undetectable		 3cb8A-1larA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		5 / 12 GLY A1527
GLY A1530
GLN A1566
VAL A1565
ILE A1574
 None
 1.21A 3h52B-1larA:
undetectable		 3h52B-1larA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 4 PRO A1335
THR A1555
GLY A1530
THR A1529
 None
 1.10A 3ib1A-1larA:
0.0		 3ib1A-1larA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		3 / 3 ARG A1505
VAL A1829
THR A1844
 None
 0.87A 3k4vA-1larA:
undetectable		 3k4vA-1larA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		3 / 3 ARG A1505
VAL A1829
THR A1844
 None
 0.84A 3nduD-1larA:
0.0		 3nduD-1larA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		3 / 3 ARG A1505
VAL A1829
THR A1844
 None
 0.85A 3pwrA-1larA:
undetectable		 3pwrA-1larA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 6 THR A1844
ILE A1809
TYR A1683
THR A1847
 None
 0.97A 3q70A-1larA:
undetectable		 3q70A-1larA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		5 / 12 PRO A1689
GLY A1688
ASN A1638
MET A1648
PHE A1630
 None
 1.23A 3r24A-1larA:
undetectable		 3r24A-1larA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 5 ASP A1536
LEU A1539
ILE A1574
PHE A1573
 None
 1.20A 3s3vA-1larA:
0.0		 3s3vA-1larA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		3 / 3 ARG A1505
VAL A1829
THR A1844
 None
 0.85A 3tl9A-1larA:
0.0		 3tl9A-1larA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		3 / 3 ARG A1354
TYR A1361
ASN A1345
 None
 0.82A 4ffwB-1larA:
2.6		 4ffwB-1larA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		5 / 12 VAL A1520
ALA A1396
PHE A1503
PHE A1532
GLY A1530
 None
 1.24A 4mm6A-1larA:
0.0		 4mm6A-1larA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		5 / 12 VAL A1811
ALA A1685
PHE A1792
PHE A1823
GLY A1821
 None
 1.29A 4mm6A-1larA:
0.0		 4mm6A-1larA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		5 / 12 ALA A1509
ILE A1790
PHE A1876
GLY A1874
LEU A1594
 None
 1.18A 5fsaA-1larA:
0.0		 5fsaA-1larA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 8 ALA A1671
VAL A1663
GLN A1736
HIS A1704
 None
 0.90A 5nu7A-1larA:
undetectable		 5nu7A-1larA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 6 PHE A1408
TRP A1409
ARG A1410
GLY A1447
 None
 1.11A 5o4yF-1larA:
undetectable		 5o4yF-1larA:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		3 / 3 TYR A1571
ALA A1577
LEU A1578
 None
 0.41A 6ag0C-1larA:
undetectable		 6ag0C-1larA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 1lar PROTEIN (LAR)
(Homo
sapiens) 		4 / 6 GLU A1616
LYS A1618
GLU A1614
ALA A1612
 None
 1.05A 6an0A-1larA:
0.4		 6an0A-1larA:
20.61