SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1lb4 TNF
RECEPTOR-ASSOCIATED
FACTOR 6
(Homo
sapiens) 		4 / 8 ILE A 352
VAL A 411
MET A 391
SER A 377
 None
 0.88A 1kb9A-1lb4A:
0.3
1kb9C-1lb4A:
undetectable
1kb9D-1lb4A:
0.0
1kb9E-1lb4A:
undetectable		 1kb9A-1lb4A:
17.52
1kb9C-1lb4A:
18.49
1kb9D-1lb4A:
18.62
1kb9E-1lb4A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lb4 TNF
RECEPTOR-ASSOCIATED
FACTOR 6
(Homo
sapiens) 		4 / 8 LEU A 389
PHE A 380
THR A 433
LEU A 432
 None
 0.93A 2eijN-1lb4A:
undetectable
2eijW-1lb4A:
0.0		 2eijN-1lb4A:
14.34
2eijW-1lb4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lb4 TNF
RECEPTOR-ASSOCIATED
FACTOR 6
(Homo
sapiens) 		4 / 7 LEU A 389
PHE A 380
THR A 433
LEU A 432
 None
 0.93A 2eikA-1lb4A:
undetectable
2eikJ-1lb4A:
0.0		 2eikA-1lb4A:
14.34
2eikJ-1lb4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lb4 TNF
RECEPTOR-ASSOCIATED
FACTOR 6
(Homo
sapiens) 		4 / 8 LEU A 389
PHE A 380
THR A 433
LEU A 432
 None
 0.94A 2eikN-1lb4A:
undetectable
2eikW-1lb4A:
undetectable		 2eikN-1lb4A:
14.34
2eikW-1lb4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1lb4 TNF
RECEPTOR-ASSOCIATED
FACTOR 6
(Homo
sapiens) 		4 / 8 ILE A 488
LEU A 393
LEU A 409
ILE A 434
 None
 0.98A 4xtaB-1lb4A:
undetectable		 4xtaB-1lb4A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1lb4 TNF
RECEPTOR-ASSOCIATED
FACTOR 6
(Homo
sapiens) 		5 / 9 GLN A 367
LEU A 393
SER A 408
LEU A 479
VAL A 373
 None
 1.48A 6ftpA-1lb4A:
0.0
6ftpB-1lb4A:
undetectable		 6ftpA-1lb4A:
16.55
6ftpB-1lb4A:
12.82