SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		4 / 7 TYR A  97
GLU A 123
MET A 129
ILE A 249
 None
 0.98A 1tuvA-1lc0A:
undetectable		 1tuvA-1lc0A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		5 / 12 ARG A 150
GLY A 147
PHE A 232
SER A 236
LEU A 212
 None
 1.35A 3iv6C-1lc0A:
3.6		 3iv6C-1lc0A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		5 / 12 ILE A 169
ILE A 277
VAL A  93
LEU A  94
PHE A  86
 None
 1.04A 3w68C-1lc0A:
undetectable		 3w68C-1lc0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		5 / 8 ASP A  68
ILE A  67
GLY A  10
VAL A  42
SER A  74
 None
 1.29A 4acbB-1lc0A:
7.9
4acbC-1lc0A:
4.9		 4acbB-1lc0A:
21.49
4acbC-1lc0A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		4 / 7 LEU A 184
ASP A 286
GLU A 181
HIS A 279
 None
 1.27A 4aq7A-1lc0A:
1.8		 4aq7A-1lc0A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		4 / 5 VAL A 228
LEU A 135
VAL A 139
PHE A 230
 None
 0.73A 4lb0B-1lc0A:
undetectable		 4lb0B-1lc0A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		4 / 6 ASP A  68
LYS A  91
HIS A  92
ARG A 118
 None
 0.77A 5a06A-1lc0A:
26.2		 5a06A-1lc0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		4 / 5 ASP A  68
LYS A  91
HIS A  92
ARG A 118
 None
 0.78A 5a06B-1lc0A:
26.1		 5a06B-1lc0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		4 / 5 ASP A  68
LYS A  91
HIS A  92
ARG A 118
 None
 0.79A 5a06D-1lc0A:
26.1		 5a06D-1lc0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		4 / 5 ASP A  68
LYS A  91
HIS A  92
ARG A 118
 None
 0.79A 5a06F-1lc0A:
26.2		 5a06F-1lc0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		3 / 3 VAL A 202
GLN A 288
CYH A 291
 None
 0.85A 5icxC-1lc0A:
undetectable
5icxF-1lc0A:
undetectable		 5icxC-1lc0A:
23.66
5icxF-1lc0A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		4 / 6 GLU A 216
LEU A 149
ARG A 150
ARG A 171
 None
 1.00A 5l6eA-1lc0A:
undetectable
5l6eB-1lc0A:
undetectable		 5l6eA-1lc0A:
20.61
5l6eB-1lc0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		4 / 6 LYS A 116
VAL A  93
LYS A  91
ILE A  83
 None
 1.44A 5q1sA-1lc0A:
undetectable		 5q1sA-1lc0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		5 / 9 LEU A 189
THR A 188
ILE A 215
PHE A 163
ILE A 287
 None
 1.17A 6ebpA-1lc0A:
0.0		 6ebpA-1lc0A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		5 / 10 LEU A 189
THR A 188
ILE A 215
PHE A 163
ILE A 287
 None
 1.16A 6ebpB-1lc0A:
undetectable		 6ebpB-1lc0A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1lc0 BILIVERDIN REDUCTASE
A
(Rattus
norvegicus) 		5 / 10 LEU A 189
THR A 188
ILE A 215
PHE A 163
ILE A 287
 None
 1.17A 6ebpC-1lc0A:
undetectable		 6ebpC-1lc0A:
14.08