SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 6 PHE A 217
TYR A 218
LEU A 260
ASP A 190
None
1.13A 1dz4A-1lc7A:
0.0
1dz4A-1lc7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 6 PHE A 217
TYR A 218
LEU A 260
ASP A 190
None
1.11A 1dz4B-1lc7A:
0.0
1dz4B-1lc7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 5 PHE A 217
TYR A 218
LEU A 260
ASP A 190
None
1.15A 1dz6A-1lc7A:
0.0
1dz6A-1lc7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 11 LEU A 353
VAL A 338
CYH A 304
TYR A 336
LEU A 315
None
1.41A 1jkhA-1lc7A:
0.0
1jkhB-1lc7A:
2.5
1jkhA-1lc7A:
21.76
1jkhB-1lc7A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 11 LEU A 353
VAL A 338
VAL A 292
TYR A 336
LEU A 315
None
1.10A 1jkhA-1lc7A:
0.0
1jkhB-1lc7A:
2.5
1jkhA-1lc7A:
21.76
1jkhB-1lc7A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 8 ALA A 339
GLY A   9
GLY A  10
PRO A 221
ALA A 219
None
TPO  A 990 (-3.5A)
None
None
None
0.96A 1sguA-1lc7A:
undetectable
1sguA-1lc7A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 7 ALA A 114
TYR A 111
ILE A 183
ASP A 185
None
0.91A 1upfB-1lc7A:
3.3
1upfB-1lc7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 12 LEU A  68
LEU A 214
GLY A  82
TYR A 227
ARG A 240
None
1.06A 2bm9A-1lc7A:
4.2
2bm9A-1lc7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
3 / 3 HIS A  71
ILE A  79
LEU A  64
None
0.73A 2kceA-1lc7A:
undetectable
2kceA-1lc7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 6 ALA A 130
ASP A 131
GLU A 129
ARG A 334
None
1.36A 2ouzA-1lc7A:
undetectable
2ouzA-1lc7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 7 ILE A  33
GLN A 345
LEU A  27
ASP A  28
None
1.06A 2qqcB-1lc7A:
0.0
2qqcC-1lc7A:
undetectable
2qqcB-1lc7A:
12.43
2qqcC-1lc7A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 7 LEU A  27
ASP A  28
ILE A  33
GLN A 345
None
1.06A 2qqcA-1lc7A:
undetectable
2qqcF-1lc7A:
undetectable
2qqcA-1lc7A:
11.01
2qqcF-1lc7A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 7 LEU A  27
ASP A  28
ILE A  33
GLN A 345
None
1.05A 2qqcI-1lc7A:
undetectable
2qqcL-1lc7A:
0.0
2qqcI-1lc7A:
11.01
2qqcL-1lc7A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 6 PHE A 217
TYR A 218
LEU A 260
ASP A 190
None
1.10A 2zawA-1lc7A:
0.0
2zawA-1lc7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 8 LEU A 353
VAL A 292
TYR A 336
LEU A 315
None
1.09A 3v81A-1lc7A:
0.0
3v81A-1lc7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 8 LEU A 353
VAL A 292
TYR A 336
LEU A 315
None
1.10A 3v81C-1lc7A:
undetectable
3v81C-1lc7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 8 VAL A 338
VAL A 292
TYR A 336
LEU A 315
None
0.84A 3v81C-1lc7A:
undetectable
3v81C-1lc7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
3 / 3 ASN A 230
TRP A 209
ASP A 233
None
1.18A 4a7tA-1lc7A:
0.0
4a7tF-1lc7A:
0.0
4a7tA-1lc7A:
18.18
4a7tF-1lc7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 12 LEU A 321
ALA A  31
ARG A 337
ASN A  32
TYR A 328
None
TPO  A 990 (-4.1A)
TPO  A 990 (-2.9A)
TPO  A 990 (-3.9A)
None
1.36A 4cpzA-1lc7A:
undetectable
4cpzA-1lc7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 12 LEU A 321
ALA A  31
ARG A 337
ASN A  32
TYR A 328
None
TPO  A 990 (-4.1A)
TPO  A 990 (-2.9A)
TPO  A 990 (-3.9A)
None
1.39A 4cpzB-1lc7A:
undetectable
4cpzB-1lc7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 12 LEU A 321
ALA A  31
ARG A 337
ASN A  32
TYR A 328
None
TPO  A 990 (-4.1A)
TPO  A 990 (-2.9A)
TPO  A 990 (-3.9A)
None
1.44A 4cpzD-1lc7A:
undetectable
4cpzD-1lc7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 12 MET A 102
LEU A 184
LEU A 152
LEU A 135
ILE A 208
None
1.10A 4f4dA-1lc7A:
2.0
4f4dA-1lc7A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 6 PHE A 217
TYR A 218
LEU A 260
ASP A 190
None
1.12A 4g3rB-1lc7A:
0.0
4g3rB-1lc7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 8 MET A 102
LEU A 184
LEU A 152
LEU A 135
ILE A 208
None
1.11A 4klaA-1lc7A:
undetectable
4klaA-1lc7A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 8 LEU A 353
VAL A 338
VAL A 292
TYR A 336
LEU A 315
None
1.06A 4puoC-1lc7A:
undetectable
4puoC-1lc7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 8 VAL A 338
VAL A 292
TYR A 336
LEU A 315
None
0.95A 4pwdA-1lc7A:
undetectable
4pwdA-1lc7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 8 VAL A 338
VAL A 292
TYR A 336
LEU A 315
None
0.94A 4q0bA-1lc7A:
undetectable
4q0bA-1lc7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 9 LEU A 353
VAL A 338
VAL A 292
TYR A 336
LEU A 315
None
0.98A 4q0bC-1lc7A:
2.0
4q0bC-1lc7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 11 ILE A  89
THR A  86
SER A 213
TYR A 111
PRO A 158
None
PO4  A 800 (-3.9A)
PO4  A 800 (-2.6A)
None
None
1.20A 5albH-1lc7A:
0.0
5albH-1lc7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 7 LEU A 182
ARG A 100
THR A 144
LEU A 143
None
0.80A 5b1aA-1lc7A:
0.0
5b1aJ-1lc7A:
undetectable
5b1aA-1lc7A:
21.47
5b1aJ-1lc7A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 7 LEU A 182
ARG A 100
THR A 144
LEU A 143
None
0.82A 5b3sA-1lc7A:
0.0
5b3sJ-1lc7A:
undetectable
5b3sA-1lc7A:
21.47
5b3sJ-1lc7A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 11 LEU A 184
GLN A 169
ASN A 205
ALA A 201
GLY A 197
None
1.14A 5cp3A-1lc7A:
0.0
5cp3H-1lc7A:
0.0
5cp3A-1lc7A:
20.11
5cp3H-1lc7A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 11 VAL A 248
SER A 247
GLU A  87
TYR A  61
LEU A  64
None
1.27A 5jh7B-1lc7A:
2.4
5jh7B-1lc7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
5 / 11 VAL A 248
SER A 247
GLU A  87
TYR A  61
LEU A  64
None
1.25A 5jh7D-1lc7A:
2.3
5jh7D-1lc7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 7 LEU A 182
ARG A 100
THR A 144
LEU A 143
None
0.89A 5xdqA-1lc7A:
0.0
5xdqJ-1lc7A:
0.0
5xdqA-1lc7A:
21.47
5xdqJ-1lc7A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 8 LEU A 182
ARG A 100
THR A 144
LEU A 143
None
0.86A 5zcoA-1lc7A:
0.0
5zcoJ-1lc7A:
0.0
5zcoA-1lc7A:
21.47
5zcoJ-1lc7A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 7 LEU A 182
ARG A 100
THR A 144
LEU A 143
None
0.87A 5zcpA-1lc7A:
0.0
5zcpJ-1lc7A:
undetectable
5zcpA-1lc7A:
21.47
5zcpJ-1lc7A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica)
4 / 7 LEU A 182
ARG A 100
THR A 144
LEU A 143
None
0.87A 5zcqA-1lc7A:
0.0
5zcqJ-1lc7A:
undetectable
5zcqA-1lc7A:
21.47
5zcqJ-1lc7A:
9.70