SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 1lcs FELINE LEUKEMIA
VIRUS
RECEPTOR-BINDING
DOMAIN
(Feline
leukemia
virus) 		4 / 6 TYR A  62
GLN A  73
ASP A  65
GLN A  66
 None
 1.33A 4azvA-1lcsA:
undetectable		 4azvA-1lcsA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1lcs FELINE LEUKEMIA
VIRUS
RECEPTOR-BINDING
DOMAIN
(Feline
leukemia
virus) 		4 / 8 SER A 200
SER A 198
ALA A  25
THR A  13
 None
 0.95A 4ikjA-1lcsA:
undetectable
4ikjB-1lcsA:
undetectable		 4ikjA-1lcsA:
20.66
4ikjB-1lcsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1lcs FELINE LEUKEMIA
VIRUS
RECEPTOR-BINDING
DOMAIN
(Feline
leukemia
virus) 		4 / 8 ALA A  25
THR A  13
SER A 200
SER A 198
 None
 0.96A 4ikkA-1lcsA:
1.6
4ikkB-1lcsA:
undetectable		 4ikkA-1lcsA:
20.66
4ikkB-1lcsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1lcs FELINE LEUKEMIA
VIRUS
RECEPTOR-BINDING
DOMAIN
(Feline
leukemia
virus) 		5 / 12 SER A 115
PHE A 197
LEU A 165
THR A 168
GLY A 171
 None
 1.09A 4zjlA-1lcsA:
undetectable		 4zjlA-1lcsA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1lcs FELINE LEUKEMIA
VIRUS
RECEPTOR-BINDING
DOMAIN
(Feline
leukemia
virus) 		3 / 3 THR A 127
PRO A 162
ASP A  42
 None
 0.91A 5l8dB-1lcsA:
undetectable		 5l8dB-1lcsA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1lcs FELINE LEUKEMIA
VIRUS
RECEPTOR-BINDING
DOMAIN
(Feline
leukemia
virus) 		3 / 3 THR A 127
PRO A 162
ASP A  42
 None
 0.91A 5mwuB-1lcsA:
undetectable		 5mwuB-1lcsA:
17.52