SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 10 LEU A 209
ALA A  97
ILE A  31
GLY A 174
VAL A  54
 None
 1.07A 1d4yA-1lcyA:
undetectable		 1d4yA-1lcyA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 GLY A  51
VAL A  53
ALA A 173
SER A 129
LEU A 133
 None
 1.35A 1kiaD-1lcyA:
undetectable		 1kiaD-1lcyA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		3 / 3 ASN A  63
PHE A  52
VAL A 187
 None
 0.72A 1kijA-1lcyA:
0.0		 1kijA-1lcyA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 11 PHE A 251
GLY A 277
VAL A 231
LEU A 274
LEU A 236
 None
 1.02A 1mx1B-1lcyA:
undetectable		 1mx1B-1lcyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 ASP A  91
GLY A 174
SER A  50
VAL A  28
ALA A  64
 None
 1.23A 1nw5A-1lcyA:
undetectable		 1nw5A-1lcyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		3 / 3 LEU A 133
PHE A 170
ARG A  74
 None
 0.85A 1xdkB-1lcyA:
undetectable		 1xdkB-1lcyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		3 / 3 LEU A 133
PHE A 170
ARG A  74
 None
 0.85A 1xdkF-1lcyA:
undetectable		 1xdkF-1lcyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 GLY A 128
THR A  24
ALA A 173
THR A 189
ALA A 199
 None
 1.05A 2gluA-1lcyA:
undetectable		 2gluA-1lcyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		4 / 7 LEU A 107
PRO A 130
VAL A  29
MET A 127
 None
 1.32A 2hrcA-1lcyA:
undetectable		 2hrcA-1lcyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		4 / 4 SER A 267
GLY A 266
HIS A 261
ASP A 169
 None
 1.30A 2oxtC-1lcyA:
undetectable		 2oxtC-1lcyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		4 / 4 THR A 138
VAL A 178
GLY A 174
THR A  62
 None
 0.86A 3cflA-1lcyA:
0.0		 3cflA-1lcyA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		4 / 7 VAL A 319
MET A 233
ILE A 280
ILE A 283
 None
 0.95A 3hgxA-1lcyA:
undetectable		 3hgxA-1lcyA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 10 GLY A 273
ARG A 310
LEU A 274
LEU A 317
ILE A 308
 None
 1.20A 3kvrA-1lcyA:
undetectable		 3kvrA-1lcyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 10 GLY A 273
ARG A 310
LEU A 274
LEU A 317
ILE A 308
 None
 1.12A 3kvrB-1lcyA:
undetectable		 3kvrB-1lcyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 9 GLY A 273
ARG A 310
LEU A 274
LEU A 317
ILE A 308
 None
 1.19A 3nbqA-1lcyA:
undetectable		 3nbqA-1lcyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		4 / 8 GLY A 273
ARG A 310
LEU A 317
ILE A 308
 None
 0.84A 3nbqB-1lcyA:
undetectable		 3nbqB-1lcyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		4 / 8 GLY A 273
ARG A 310
LEU A 317
ILE A 308
 None
 0.86A 3nbqC-1lcyA:
0.0		 3nbqC-1lcyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 9 GLY A 273
ARG A 310
LEU A 274
LEU A 317
ILE A 308
 None
 1.24A 3nbqD-1lcyA:
undetectable		 3nbqD-1lcyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 MET A 127
LEU A 110
PHE A 208
ILE A 101
ALA A  85
 None
 1.09A 3nxuB-1lcyA:
undetectable		 3nxuB-1lcyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 VAL A  54
LEU A 209
VAL A 187
GLY A 186
LEU A 112
 None
 0.94A 3rr3A-1lcyA:
undetectable		 3rr3A-1lcyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 VAL A  54
LEU A 209
VAL A 187
GLY A 186
LEU A 112
 None
 0.94A 3rr3B-1lcyA:
undetectable		 3rr3B-1lcyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 11 LEU A 205
ILE A  31
ILE A  60
VAL A  54
LEU A  59
 None
 1.14A 3w67A-1lcyA:
undetectable		 3w67A-1lcyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 ILE A 141
LEU A 110
GLY A 186
ASN A 188
ILE A 185
 None
 0.94A 4o1eB-1lcyA:
undetectable		 4o1eB-1lcyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 GLY A 186
GLY A  51
GLY A 174
VAL A  75
ILE A  60
 None
 0.88A 5ec8A-1lcyA:
undetectable		 5ec8A-1lcyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 GLY A 186
GLY A  51
GLY A 174
VAL A  75
ILE A  60
 None
 0.91A 5ehgA-1lcyA:
undetectable		 5ehgA-1lcyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 VAL A 184
ILE A  96
LEU A 209
LEU A  59
VAL A  54
 None
 1.17A 5im2A-1lcyA:
undetectable		 5im2A-1lcyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 GLY A 186
GLY A  51
GLY A 174
VAL A  75
ILE A  60
 None
 0.97A 5vimA-1lcyA:
undetectable		 5vimA-1lcyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens) 		5 / 12 GLY A 186
GLY A  51
GLY A 174
VAL A  75
ILE A  60
 None
 0.96A 5vimB-1lcyA:
undetectable		 5vimB-1lcyA:
21.41