SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ldj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 8 ALA A 218
LEU A 133
SER A 161
THR A 166
 None
 0.79A 1dvtA-1ldjA:
undetectable
1dvtB-1ldjA:
undetectable		 1dvtA-1ldjA:
10.55
1dvtB-1ldjA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 5 PHE A 462
TYR A 466
LEU A 430
VAL A 367
 None
 1.40A 1dz6A-1ldjA:
0.0		 1dz6A-1ldjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 6 PHE A 462
ILE A 703
ALA A 423
MET A 469
 None
 1.27A 1hk2A-1ldjA:
0.9		 1hk2A-1ldjA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		5 / 12 VAL A 205
LEU A 279
PHE A 236
LEU A 237
GLU A 271
 None
 1.37A 1mmkA-1ldjA:
undetectable		 1mmkA-1ldjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 7 LEU A 287
LEU A 279
ILE A 201
GLU A 271
 None
 1.03A 1n13I-1ldjA:
undetectable
1n13L-1ldjA:
0.0		 1n13I-1ldjA:
5.69
1n13L-1ldjA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 8 ASP A 510
TYR A 570
GLY A 512
ASP A 516
 None
 0.83A 1rmtC-1ldjA:
undetectable		 1rmtC-1ldjA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 6 ALA A 484
GLU A 485
ILE A 489
LEU A 446
 None
 0.93A 1xvaA-1ldjA:
undetectable
1xvaB-1ldjA:
undetectable		 1xvaA-1ldjA:
16.69
1xvaB-1ldjA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 4 LEU A 559
SER A 562
TYR A 563
LEU A 555
 None
 0.82A 1xz1A-1ldjA:
0.5		 1xz1A-1ldjA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 4 LEU A 559
SER A 562
TYR A 563
LEU A 555
 None
 0.82A 1xz3A-1ldjA:
2.5		 1xz3A-1ldjA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 5 ILE A 159
ARG A 146
LEU A 140
ASN A 141
 None
 1.10A 1y0xX-1ldjA:
1.5		 1y0xX-1ldjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 8 THR A 283
VAL A 205
THR A 180
ILE A 187
 None
 0.78A 2a1mB-1ldjA:
0.0		 2a1mB-1ldjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 7 TYR A 157
LEU A 162
VAL A 165
THR A 166
 None
 0.88A 2qblA-1ldjA:
0.0		 2qblA-1ldjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 6 ILE A  28
ARG A  25
LEU A  24
LEU A  96
 None
 1.06A 2rlfA-1ldjA:
0.0
2rlfD-1ldjA:
0.0		 2rlfA-1ldjA:
5.47
2rlfD-1ldjA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		5 / 10 LEU A 422
LEU A 430
LEU A 446
VAL A 449
PHE A 462
 None
 1.08A 2w9gA-1ldjA:
undetectable		 2w9gA-1ldjA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		5 / 12 THR A 166
ILE A 159
LEU A 162
VAL A  49
LEU A  88
 None
 1.17A 3a51C-1ldjA:
2.3		 3a51C-1ldjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 5 VAL A 686
GLN A 602
PHE A 606
ARG A 681
 None
 1.41A 3bjwE-1ldjA:
0.0		 3bjwE-1ldjA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 5 VAL A 686
GLN A 602
PHE A 606
ARG A 681
 None
 1.35A 3bjwH-1ldjA:
0.4		 3bjwH-1ldjA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 6 LEU A 559
SER A 562
TYR A 563
LEU A 555
 None
 0.85A 3f33A-1ldjA:
2.3		 3f33A-1ldjA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		5 / 12 VAL A 734
ALA A 714
ARG A 764
LEU A 762
ASP A 754
 None
 0.92A 3gcsA-1ldjA:
undetectable		 3gcsA-1ldjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 7 GLU A 230
LEU A 164
TRP A 123
ASN A 214
 None
 1.20A 3k8mB-1ldjA:
undetectable		 3k8mB-1ldjA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 6 LEU A 559
SER A 562
TYR A 563
LEU A 555
 None
 0.81A 3ravA-1ldjA:
2.3		 3ravA-1ldjA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 8 VAL A  49
LEU A  88
ASN A 141
ILE A 159
 None
 0.91A 3u5kD-1ldjA:
undetectable		 3u5kD-1ldjA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 4 LEU A 756
ALA A 714
ILE A 711
LYS A 759
 None
 1.49A 4eixA-1ldjA:
1.4		 4eixA-1ldjA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		3 / 3 LEU A 775
VAL A 765
ASP A 766
 None
 0.68A 4y8wC-1ldjA:
undetectable		 4y8wC-1ldjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		3 / 3 PHE A 303
ILE A 296
ASP A 331
 None
 0.73A 5cswB-1ldjA:
1.4		 5cswB-1ldjA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 6 ALA A 423
LEU A 422
ILE A 456
TYR A 500
 None
 0.77A 5mvmB-1ldjA:
3.3
5mvmC-1ldjA:
3.1		 5mvmB-1ldjA:
8.44
5mvmC-1ldjA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		3 / 3 HIS A 343
ASN A 346
ALA A 350
 None
 0.51A 5n4tB-1ldjA:
undetectable		 5n4tB-1ldjA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		5 / 12 MET A 469
ALA A 423
LEU A 430
VAL A 367
ASP A 444
 None
 1.48A 5vlmD-1ldjA:
2.2		 5vlmD-1ldjA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 8 ILE A 403
GLN A 368
VAL A 373
ASP A 396
 None
 1.17A 5vlmF-1ldjA:
0.5		 5vlmF-1ldjA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1ldj CULLIN HOMOLOG 1
(Homo
sapiens) 		4 / 7 LEU A 380
ASP A 314
GLN A 347
GLN A 308
 None
 1.41A 6g31D-1ldjA:
2.2		 6g31D-1ldjA:
8.27