SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ldk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 8 TYR A 377
LEU A 336
LEU A 380
GLU A 306
 None
 1.01A 1i7zA-1ldkA:
undetectable		 1i7zA-1ldkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		3 / 3 LEU B 756
LEU B 775
MET B 719
 None
 0.64A 1ya3B-1ldkB:
0.0		 1ya3B-1ldkB:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 4 LYS B 454
ALA B 495
PHE B 498
GLY B 497
 None
 1.49A 2rddA-1ldkB:
0.0		 2rddA-1ldkB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		3 / 3 LEU A 200
ARG A 199
ILE A 201
 None
 0.64A 2xn5B-1ldkA:
undetectable		 2xn5B-1ldkA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		3 / 3 SER B 414
ARG B 745
GLN B 413
 None
 1.01A 2xnrA-1ldkB:
1.1		 2xnrA-1ldkB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 8 ASP A 106
TYR A 126
TRP A 167
TYR A  99
 None
 1.28A 2xz5A-1ldkA:
undetectable
2xz5C-1ldkA:
undetectable		 2xz5A-1ldkA:
18.72
2xz5C-1ldkA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		5 / 12 VAL A 132
TYR A  46
TYR A  42
ASN A  51
ARG A  91
 None
 1.34A 2zthA-1ldkA:
undetectable		 2zthA-1ldkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		3 / 3 MET B 450
GLU B 443
ASP B 483
 None
 1.10A 3a25A-1ldkB:
undetectable		 3a25A-1ldkB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		5 / 12 THR A 166
ILE A 159
LEU A 162
VAL A  49
LEU A  88
 None
 1.10A 3a51C-1ldkA:
0.6		 3a51C-1ldkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 8 TYR A  50
TYR A 139
SER A  55
ILE A  15
 None
 0.95A 3jz0B-1ldkA:
3.3		 3jz0B-1ldkA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		5 / 12 ALA B 656
THR B 667
ILE B 669
LEU B 640
LEU B 663
 None
 1.02A 3k2hA-1ldkB:
undetectable		 3k2hA-1ldkB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 5 ILE B 635
THR B 690
GLU B 695
GLU B 697
 None
 1.19A 3ny4A-1ldkB:
1.0		 3ny4A-1ldkB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 8 TYR B 455
ILE A 403
ILE B 456
VAL A 370
 None
 0.84A 3p4wC-1ldkB:
0.4		 3p4wC-1ldkB:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 7 LEU B 644
LEU B 649
GLU B 652
ILE B 669
 None
 0.84A 3s56B-1ldkB:
undetectable		 3s56B-1ldkB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		3 / 3 LYS A 229
ARG A 289
LEU A 237
 None
 1.17A 3v4tE-1ldkA:
undetectable		 3v4tE-1ldkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		3 / 3 ASP B 458
LYS B 459
ASP B 460
 None
 0.81A 4a7tA-1ldkB:
undetectable		 4a7tA-1ldkB:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		3 / 3 LEU B 559
GLU B 560
SER B 557
 None
 0.64A 4ccqA-1ldkB:
undetectable		 4ccqA-1ldkB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		3 / 3 ARG B 573
HIS B 574
SER B 572
 None
 0.79A 4mjwA-1ldkB:
undetectable
4mjwB-1ldkB:
undetectable		 4mjwA-1ldkB:
20.40
4mjwB-1ldkB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		3 / 3 SER B 572
ARG B 573
HIS B 574
 None
 0.76A 4mjwA-1ldkB:
undetectable
4mjwB-1ldkB:
undetectable		 4mjwA-1ldkB:
20.40
4mjwB-1ldkB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 8 LYS A 263
ALA A 264
LEU A 268
LEU A 325
 None
 0.82A 4po0A-1ldkA:
2.3		 4po0A-1ldkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 4 LEU A 200
ARG A 274
ILE A 201
ILE A 187
 None
 0.95A 5dzk2-1ldkA:
undetectable
5dzkM-1ldkA:
0.0
5dzkN-1ldkA:
0.0		 5dzk2-1ldkA:
2.22
5dzkM-1ldkA:
19.24
5dzkN-1ldkA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 200
ARG A 274
ILE A 201
ILE A 187
 None
 0.98A 5dzk4-1ldkA:
undetectable
5dzkg-1ldkA:
undetectable
5dzkm-1ldkA:
undetectable
5dzkn-1ldkA:
undetectable		 5dzk4-1ldkA:
2.22
5dzkg-1ldkA:
19.40
5dzkm-1ldkA:
19.24
5dzkn-1ldkA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 4 ILE A 201
ILE A 187
ARG A 274
LEU A 200
 None
 1.05A 5dzkh-1ldkA:
undetectable
5dzkn-1ldkA:
0.0
5dzkv-1ldkA:
undetectable		 5dzkh-1ldkA:
19.24
5dzkn-1ldkA:
19.24
5dzkv-1ldkA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 6 LEU A 279
LEU A 237
PHE A 232
LEU A 184
 None
 0.99A 5gs4A-1ldkA:
0.0		 5gs4A-1ldkA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 5 TYR A  42
SER A  40
ALA A  38
GLN A  30
 None
 1.20A 5n0tA-1ldkA:
0.0		 5n0tA-1ldkA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		3 / 3 HIS A 343
ASN A 346
ALA A 350
 None
 0.24A 5n4tB-1ldkA:
undetectable		 5n4tB-1ldkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 4 GLY A 212
LEU A 213
VAL A 227
GLU A 230
 None
 1.42A 5yw0A-1ldkA:
undetectable		 5yw0A-1ldkA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 7 ILE B 635
GLN B 638
VAL B 639
THR B 605
 None
 0.98A 6cduC-1ldkB:
2.0
6cduD-1ldkB:
1.7		 6cduC-1ldkB:
23.21
6cduD-1ldkB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ldk CULLIN HOMOLOG
(Homo
sapiens) 		4 / 8 ILE B 635
GLN B 638
VAL B 639
THR B 605
 None
 1.04A 6cduG-1ldkB:
1.6
6cduH-1ldkB:
1.5		 6cduG-1ldkB:
23.21
6cduH-1ldkB:
23.21