SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ldn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 274
VAL A 158
TRP A 148
 None
 0.96A 1c4dA-1ldnA:
undetectable
1c4dB-1ldnA:
undetectable		 1c4dA-1ldnA:
6.40
1c4dB-1ldnA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A 148
ALA A 274
VAL A 158
 None
 0.80A 1c4dA-1ldnA:
undetectable
1c4dB-1ldnA:
undetectable		 1c4dA-1ldnA:
6.40
1c4dB-1ldnA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A  46
GLY A  20
ALA A  21
ASP A  90
ILE A  44
 None
 0.89A 1hshC-1ldnA:
undetectable		 1hshC-1ldnA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 147
ASN A 113
GLY A  32
THR A 137
ALA A 136
 None
NAD  A 352 ( 4.6A)
None
NAD  A 352 (-3.7A)
NAD  A 352 (-4.3A)
 1.13A 1jg4A-1ldnA:
2.6		 1jg4A-1ldnA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A  46
GLY A  20
ALA A  21
ASP A  90
ILE A  44
 None
 0.89A 1sguB-1ldnA:
undetectable		 1sguB-1ldnA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 11 ASP A  46
GLY A  20
ALA A  21
ASP A  90
ILE A  44
 None
 0.84A 2b60B-1ldnA:
undetectable		 2b60B-1ldnA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 6 ALA A  33
PHE A  65
ILE A  48
VAL A  25
 None
 0.92A 2cizA-1ldnA:
0.0		 2cizA-1ldnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  32
GLY A  27
ALA A 136
THR A 137
ALA A 252
 None
NAD  A 352 (-3.6A)
NAD  A 352 (-4.3A)
NAD  A 352 (-3.7A)
None
 1.08A 2gluA-1ldnA:
4.8		 2gluA-1ldnA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A  91
ILE A 159
ILE A 293
ALA A 261
 None
 0.78A 2i30A-1ldnA:
0.0		 2i30A-1ldnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A 321
ASP A 141
GLY A 162
ILE A 189
ALA A 318
ILE A 287
 None
 1.26A 2nmzA-1ldnA:
undetectable		 2nmzA-1ldnA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A  39
ASP A  77
ILE A  78
GLY A  81
ILE A  51
ILE A  48
 None
 1.47A 2rkfB-1ldnA:
undetectable		 2rkfB-1ldnA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 7 LEU A 143
ALA A  98
GLY A  97
PHE A 117
PHE A 150
 None
None
NAD  A 352 (-4.2A)
None
None
 1.48A 2wq5A-1ldnA:
0.4		 2wq5A-1ldnA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 164
LEU A 270
ILE A 293
ALA A 261
LEU A 134
 None
 1.05A 3a50A-1ldnA:
0.0		 3a50A-1ldnA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 PRO A  73
PHE A  65
LYS A  69
 None
 0.99A 3bjwG-1ldnA:
undetectable		 3bjwG-1ldnA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 8 LEU A 321
ASP A 141
GLY A 162
ILE A 189
ILE A 287
 None
 1.15A 3ekpA-1ldnA:
undetectable		 3ekpA-1ldnA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 198
SER A 317
ILE A 190
SER A 273
GLY A 288
 None
 1.16A 3ijxB-1ldnA:
undetectable
3ijxD-1ldnA:
undetectable		 3ijxB-1ldnA:
20.92
3ijxD-1ldnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 ILE A 190
SER A 273
GLY A 288
LEU A 198
SER A 317
 None
 1.20A 3ik6B-1ldnA:
0.0
3ik6E-1ldnA:
0.0		 3ik6B-1ldnA:
20.92
3ik6E-1ldnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 198
SER A 317
ILE A 190
SER A 273
GLY A 288
 None
 1.09A 3ik6B-1ldnA:
0.0
3ik6E-1ldnA:
undetectable		 3ik6B-1ldnA:
20.92
3ik6E-1ldnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 198
SER A 317
ILE A 190
SER A 273
GLY A 288
 None
 1.10A 3iluB-1ldnA:
0.0
3iluE-1ldnA:
0.0		 3iluB-1ldnA:
20.92
3iluE-1ldnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 11 ILE A 190
SER A 273
GLY A 288
LEU A 198
SER A 317
 None
 1.11A 3iluB-1ldnA:
0.0
3iluE-1ldnA:
0.0		 3iluB-1ldnA:
20.92
3iluE-1ldnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A  47
ASP A  90
ASP A  85
 None
 0.78A 3jb2A-1ldnA:
0.0		 3jb2A-1ldnA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A 159
ASP A  88
GLY A 131
VAL A  25
 None
 0.98A 3n3iA-1ldnA:
undetectable		 3n3iA-1ldnA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 9 ASP A  46
GLY A  20
ALA A  21
ASP A  90
ILE A  44
 None
 0.99A 3s53A-1ldnA:
undetectable		 3s53A-1ldnA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 7 ASP A  46
GLY A  20
ALA A  21
ASP A  90
 None
 0.71A 3t3cA-1ldnA:
undetectable		 3t3cA-1ldnA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 106
ARG A 169
ASP A 235
 OXM  A 351 (-4.2A)
OXM  A 351 (-3.5A)
None
 0.90A 3wipG-1ldnA:
0.0
3wipH-1ldnA:
0.0		 3wipG-1ldnA:
21.23
3wipH-1ldnA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 5 VAL A 215
LEU A 226
ILE A 211
ARG A 212
 None
 0.87A 4mghA-1ldnA:
0.0		 4mghA-1ldnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 6 VAL A 215
LEU A 214
ARG A 212
LEU A 174
 None
 1.10A 4o1zA-1ldnA:
undetectable		 4o1zA-1ldnA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 9 ASP A  52
TYR A  83
ALA A  96
ILE A 116
ILE A 120
 NAD  A 352 (-2.9A)
None
NAD  A 352 (-3.4A)
NAD  A 352 ( 4.3A)
None
 0.63A 4oknB-1ldnA:
41.3		 4oknB-1ldnA:
36.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 263
LEU A 134
LEU A 132
ILE A 298
LEU A 270
 None
 1.09A 5gtrA-1ldnA:
undetectable		 5gtrA-1ldnA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A  51
GLY A  81
LEU A 263
CYH A  95
 None
 0.89A 5hieB-1ldnA:
undetectable		 5hieB-1ldnA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 129
ALA A 136
SER A 161
VAL A  93
ILE A  94
 None
NAD  A 352 (-4.3A)
NAD  A 352 (-3.1A)
None
None
 1.39A 5mlmA-1ldnA:
7.5		 5mlmA-1ldnA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 136
VAL A 135
GLY A  97
PHE A 117
ALA A  98
 NAD  A 352 (-4.3A)
None
NAD  A 352 (-4.2A)
None
None
 1.20A 5n5dA-1ldnA:
4.0		 5n5dA-1ldnA:
22.15