SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1le8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 1le8 MATING-TYPE PROTEIN
ALPHA-2
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 162
SER B 172
ASN B 178
 None
 0.79A 1bx4A-1le8B:
undetectable		 1bx4A-1le8B:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 1le8 MATING-TYPE PROTEIN
ALPHA-2
(Saccharomyces
cerevisiae) 		3 / 3 ALA B 185
VAL B 180
TRP B 179
 None
 0.77A 1kqeA-1le8B:
undetectable
1kqeE-1le8B:
undetectable		 1kqeA-1le8B:
9.43
1kqeE-1le8B:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 1le8 MATING-TYPE PROTEIN
ALPHA-2
(Saccharomyces
cerevisiae) 		3 / 3 ALA B 185
VAL B 180
TRP B 179
 None
 0.76A 1kqeB-1le8B:
undetectable
1kqeD-1le8B:
undetectable		 1kqeB-1le8B:
9.43
1kqeD-1le8B:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 1le8 MATING-TYPE PROTEIN
ALPHA-2
(Saccharomyces
cerevisiae) 		3 / 3 TRP B 179
ALA B 185
VAL B 180
 None
 0.77A 1kqeB-1le8B:
undetectable
1kqeD-1le8B:
undetectable		 1kqeB-1le8B:
9.43
1kqeD-1le8B:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 1le8 MATING-TYPE PROTEIN
ALPHA-2
(Saccharomyces
cerevisiae) 		3 / 3 TRP B 179
ALA B 185
VAL B 180
 None
 0.75A 1kqeA-1le8B:
undetectable
1kqeE-1le8B:
undetectable		 1kqeA-1le8B:
9.43
1kqeE-1le8B:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1le8 MATING-TYPE PROTEIN
ALPHA-2
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 144
TRP B 147
GLY B 161
 None
 0.80A 3l35A-1le8B:
1.2
3l35H-1le8B:
undetectable		 3l35A-1le8B:
24.66
3l35H-1le8B:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1le8 MATING-TYPE PROTEIN
ALPHA-2
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 144
TRP B 147
GLY B 161
 None
 0.78A 3l35B-1le8B:
1.0
3l35K-1le8B:
undetectable		 3l35B-1le8B:
24.66
3l35K-1le8B:
12.66