SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1led'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 GLY A 194
LEU A 189
SER A 190
SER A 170
LEU A  80
 None
 1.26A 3bxoA-1ledA:
undetectable		 3bxoA-1ledA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 PHE A  78
LEU A  80
GLY A 222
GLY A  90
LEU A  91
 None
None
GAL  A 253 (-3.5A)
None
None
 1.09A 3e23A-1ledA:
undetectable		 3e23A-1ledA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 PHE A  78
VAL A 187
LEU A 199
TYR A 191
THR A 159
 None
 1.30A 3elzC-1ledA:
0.9		 3elzC-1ledA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		4 / 5 GLN A  36
THR A  38
GLU A 225
THR A  87
 None
 1.41A 3glqA-1ledA:
undetectable		 3glqA-1ledA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		4 / 6 HIS A 145
VAL A 187
ILE A 153
LEU A 185
 MN  A 250 ( 3.4A)
None
None
None
 0.86A 3kk6A-1ledA:
undetectable		 3kk6A-1ledA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 GLY A 110
SER A 101
GLY A  26
ASP A 149
PHE A 108
 None
NAG  A 256 (-2.7A)
FUC  A 262 (-3.4A)
None
FUC  A 252 ( 4.6A)
 1.30A 3r24A-1ledA:
undetectable		 3r24A-1ledA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		4 / 8 TYR A   8
GLU A  21
LEU A  35
PHE A  24
 SO4  A 500 (-3.9A)
SO4  A 500 (-3.8A)
None
None
 1.06A 3rqwC-1ledA:
undetectable
3rqwD-1ledA:
undetectable		 3rqwC-1ledA:
20.29
3rqwD-1ledA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		4 / 8 GLU A  21
LEU A  35
PHE A  24
TYR A   8
 SO4  A 500 (-3.8A)
None
None
SO4  A 500 (-3.9A)
 1.04A 3rqwF-1ledA:
undetectable
3rqwJ-1ledA:
0.0		 3rqwF-1ledA:
20.29
3rqwJ-1ledA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		4 / 5 ASP A 165
GLY A 194
TYR A 197
GLU A 162
 None
 1.46A 3w9tA-1ledA:
0.0		 3w9tA-1ledA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		4 / 5 ASP A 165
GLY A 194
TYR A 197
GLU A 162
 None
 1.46A 3w9tC-1ledA:
0.0		 3w9tC-1ledA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		4 / 5 ASP A 165
GLY A 194
TYR A 197
GLU A 162
 None
 1.45A 3w9tD-1ledA:
0.0		 3w9tD-1ledA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		4 / 5 ASP A 165
GLY A 194
TYR A 197
GLU A 162
 None
 1.46A 3w9tG-1ledA:
undetectable		 3w9tG-1ledA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 SER A 190
PHE A  93
ILE A 176
PHE A  76
HIS A 233
 None
 1.41A 4c49C-1ledA:
0.0		 4c49C-1ledA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		3 / 3 PHE A  78
TYR A 197
TYR A 191
 None
 1.04A 4ffwA-1ledA:
1.3		 4ffwA-1ledA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 SER A 169
THR A  87
ALA A  85
GLY A  90
THR A 227
 None
 1.23A 4qvnV-1ledA:
undetectable
4qvnb-1ledA:
undetectable		 4qvnV-1ledA:
23.53
4qvnb-1ledA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 SER A 169
THR A  87
ALA A  85
GLY A  90
THR A 227
 None
 1.23A 4qvnH-1ledA:
undetectable
4qvnN-1ledA:
undetectable		 4qvnH-1ledA:
23.53
4qvnN-1ledA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 GLY A 107
GLY A 106
GLY A  90
ILE A 146
TYR A 143
 GAL  A 253 ( 3.4A)
FUC  A 254 ( 3.8A)
None
None
None
 0.96A 4rtmA-1ledA:
undetectable		 4rtmA-1ledA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 10 TRP A 161
PHE A  76
LEU A  37
SER A 218
ALA A  92
 None
 1.37A 4z69I-1ledA:
undetectable		 4z69I-1ledA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 ASP A  89
ASN A  82
ARG A  48
PRO A  86
GLY A  84
 GAL  A 253 ( 2.8A)
None
FUC  A 254 ( 4.2A)
None
None
 1.20A 6gnfA-1ledA:
undetectable		 6gnfA-1ledA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		3 / 3 TRP A 232
ILE A 215
GLU A  58
 None
 0.74A 6hcxA-1ledA:
undetectable		 6hcxA-1ledA:
17.52