SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1leh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		4 / 8 ILE A 233
LEU A 174
ALA A 165
VAL A 255
 None
 0.60A 1a29A-1lehA:
undetectable		 1a29A-1lehA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		4 / 8 GLY A  78
ASN A  69
GLY A  77
VAL A 294
 None
 0.81A 1dbbH-1lehA:
undetectable
1dbbL-1lehA:
undetectable		 1dbbH-1lehA:
20.16
1dbbL-1lehA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		5 / 12 ILE A 286
LEU A 188
VAL A 255
ALA A 162
ILE A 233
 None
 1.02A 1epbB-1lehA:
0.0		 1epbB-1lehA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		5 / 12 GLY A 180
GLY A 182
ALA A 187
LEU A 188
VAL A 242
 None
 1.23A 1i9gA-1lehA:
5.6		 1i9gA-1lehA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		5 / 11 ALA A  43
THR A 112
ILE A 126
ILE A  83
ALA A  27
 None
 0.96A 2qhfA-1lehA:
undetectable		 2qhfA-1lehA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		4 / 5 LYS A 159
ASP A 169
TYR A 314
GLU A 318
 None
 1.24A 2x8oA-1lehA:
undetectable		 2x8oA-1lehA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		3 / 3 PRO A  38
LEU A  76
ARG A 309
 None
 0.85A 3aqiA-1lehA:
3.3		 3aqiA-1lehA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		5 / 12 GLY A  41
GLY A  78
ILE A 111
ALA A 113
LEU A  61
 None
 1.15A 3ckkA-1lehA:
4.6		 3ckkA-1lehA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		5 / 9 ILE A 360
LEU A 298
ILE A 292
LYS A  80
GLY A  41
 None
 1.47A 3sj4X-1lehA:
undetectable		 3sj4X-1lehA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		4 / 6 THR A 150
GLY A 153
ILE A 286
LEU A 188
 None
 1.16A 4ac9C-1lehA:
undetectable		 4ac9C-1lehA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		4 / 6 THR A 150
GLY A 153
ILE A 286
LEU A 188
 None
 1.11A 4acaC-1lehA:
undetectable		 4acaC-1lehA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		5 / 9 ILE A   3
GLN A  14
LEU A  15
VAL A  28
LEU A  59
 None
 1.16A 4g1bC-1lehA:
5.1		 4g1bC-1lehA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		5 / 11 PHE A 321
ILE A 256
ALA A 161
ALA A 162
VAL A 176
 None
 1.05A 4h1nA-1lehA:
undetectable		 4h1nA-1lehA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		5 / 12 ASN A  69
GLY A 290
GLY A 289
GLY A 144
PHE A 140
 None
 1.03A 4obwB-1lehA:
4.8		 4obwB-1lehA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		5 / 12 SER A 331
PRO A 282
ILE A 286
VAL A 279
VAL A 255
 None
 1.49A 4yfbI-1lehA:
undetectable		 4yfbI-1lehA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		5 / 12 SER A 331
PRO A 282
ILE A 286
VAL A 279
VAL A 255
 None
 1.50A 4yfbL-1lehA:
undetectable		 4yfbL-1lehA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		5 / 10 ALA A  72
ILE A 292
GLY A  77
LEU A  76
ALA A 295
 None
 1.42A 5ajqB-1lehA:
undetectable		 5ajqB-1lehA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		4 / 8 LEU A 192
MET A 158
ILE A 233
ASP A 232
 None
 0.79A 5y9mA-1lehA:
undetectable		 5y9mA-1lehA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		4 / 7 VAL A 178
MET A 158
ILE A 233
ASP A 232
 None
 0.90A 5yf9B-1lehA:
undetectable		 5yf9B-1lehA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		4 / 5 HIS A 274
ALA A 334
SER A 324
GLY A 328
 None
 1.19A 5yodB-1lehA:
undetectable		 5yodB-1lehA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1leh LEUCINE
DEHYDROGENASE
(Lysinibacillus
sphaericus) 		4 / 7 ALA A 197
GLY A 196
GLY A 217
CYH A 189
 None
 0.80A 6nm4A-1lehA:
undetectable		 6nm4A-1lehA:
18.68