SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1leo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1leo NUCLEOSIDE
DIPHOSPHATE KINASE
(Dictyostelium
discoideum) 		5 / 12 THR A  11
GLY A 123
SER A 124
VAL A  15
ILE A 120
 None
 0.96A 2b25B-1leoA:
undetectable		 2b25B-1leoA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1leo NUCLEOSIDE
DIPHOSPHATE KINASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  86
GLY A  84
GLY A  36
GLU A  83
VAL A  88
 None
 1.05A 2oxtA-1leoA:
undetectable		 2oxtA-1leoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1leo NUCLEOSIDE
DIPHOSPHATE KINASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  86
GLY A  84
GLY A  36
GLU A  83
VAL A  88
 None
 1.00A 2oxtC-1leoA:
undetectable		 2oxtC-1leoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1leo NUCLEOSIDE
DIPHOSPHATE KINASE
(Dictyostelium
discoideum) 		4 / 5 SER A 103
GLY A 123
GLU A  58
GLU A 133
 None
 1.45A 3raeB-1leoA:
1.8
3raeD-1leoA:
undetectable		 3raeB-1leoA:
14.91
3raeD-1leoA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1leo NUCLEOSIDE
DIPHOSPHATE KINASE
(Dictyostelium
discoideum) 		4 / 6 HIS A 122
GLU A 133
ASP A 125
SER A 129
 None
 1.25A 4apjA-1leoA:
undetectable
4apjP-1leoA:
undetectable		 4apjA-1leoA:
13.82
4apjP-1leoA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 1leo NUCLEOSIDE
DIPHOSPHATE KINASE
(Dictyostelium
discoideum) 		4 / 4 LYS A  43
LEU A  45
ALA A  79
VAL A  81
 None
 1.03A 4ik6A-1leoA:
0.0		 4ik6A-1leoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1leo NUCLEOSIDE
DIPHOSPHATE KINASE
(Dictyostelium
discoideum) 		5 / 12 ILE A  28
ARG A 109
ALA A  91
ARG A  92
LEU A  13
 None
 1.47A 4zo1X-1leoA:
0.0		 4zo1X-1leoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1leo NUCLEOSIDE
DIPHOSPHATE KINASE
(Dictyostelium
discoideum) 		4 / 5 SER A 124
ALA A 130
HIS A 122
LEU A  13
 None
 1.43A 5dzkc-1leoA:
undetectable
5dzkq-1leoA:
undetectable		 5dzkc-1leoA:
18.89
5dzkq-1leoA:
1.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1leo NUCLEOSIDE
DIPHOSPHATE KINASE
(Dictyostelium
discoideum) 		4 / 8 SER A 124
ALA A 130
HIS A 122
LEU A 136
 None
 1.19A 5dzkd-1leoA:
undetectable
5dzkr-1leoA:
undetectable		 5dzkd-1leoA:
18.89
5dzkr-1leoA:
1.44