SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lf9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ALA A 319
TRP A 341
ARG A 343
ASP A 344
GLY A 392
 ACR  A 700 (-3.2A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
None
 0.62A 1agmA-1lf9A:
29.7		 1agmA-1lf9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		10 / 12 ALA A 319
TYR A 337
TRP A 341
ARG A 343
ASP A 344
GLU A 439
ARG A 575
TYR A 581
TRP A 599
GLU A 636
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.3A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
None
None
 0.32A 1agmA-1lf9A:
29.7		 1agmA-1lf9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		6 / 12 ALA A 319
TYR A 337
TRP A 390
GLU A 439
TYR A 581
GLU A 636
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.3A)
ACR  A 700 ( 3.8A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.7A)
None
 0.99A 1agmA-1lf9A:
29.7		 1agmA-1lf9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_2
(GLUCOAMYLASE-471)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 4 TRP A 437
GLU A 438
LEU A 652
TRP A 654
 ACR  A 700 (-4.8A)
ACR  A 700 (-3.5A)
None
None
 0.48A 1agmA-1lf9A:
29.7		 1agmA-1lf9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ALA A 319
TRP A 341
ARG A 343
ASP A 344
GLY A 392
 ACR  A 700 (-3.2A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
None
 0.62A 1agmA-1lf9A:
29.7		 1agmA-1lf9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		10 / 12 ALA A 319
TYR A 337
TRP A 341
ARG A 343
ASP A 344
GLU A 439
ARG A 575
TYR A 581
TRP A 599
GLU A 636
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.3A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
None
None
 0.32A 1agmA-1lf9A:
29.7		 1agmA-1lf9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		6 / 12 ALA A 319
TYR A 337
TRP A 390
GLU A 439
TYR A 581
GLU A 636
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.3A)
ACR  A 700 ( 3.8A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.7A)
None
 0.99A 1agmA-1lf9A:
29.7		 1agmA-1lf9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_2
(GLUCOAMYLASE-471)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 5 TRP A 437
GLU A 438
LEU A 652
TRP A 654
 ACR  A 700 (-4.8A)
ACR  A 700 (-3.5A)
None
None
 0.48A 1agmA-1lf9A:
29.7		 1agmA-1lf9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ASN A  19
ILE A 230
PRO A 157
GLY A 168
THR A 188
 None
 1.47A 1g60B-1lf9A:
undetectable		 1g60B-1lf9A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_1
(GLUCOAMYLASE-471)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 TRP A 341
ARG A 343
ASP A 344
GLY A 392
GLU A 438
 ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
None
ACR  A 700 (-3.5A)
 0.72A 1gahA-1lf9A:
29.6		 1gahA-1lf9A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_1
(GLUCOAMYLASE-471)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		9 / 12 TYR A 337
TRP A 341
ARG A 343
ASP A 344
GLU A 438
GLU A 439
TYR A 581
TRP A 599
GLU A 636
 ACR  A 700 (-4.3A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.5A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.7A)
None
None
 0.31A 1gahA-1lf9A:
29.6		 1gahA-1lf9A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 6 ALA A 319
TRP A 437
ARG A 575
LEU A 652
TRP A 654
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.8A)
ACR  A 700 (-3.0A)
None
None
 0.41A 1gahA-1lf9A:
29.6		 1gahA-1lf9A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 THR A 646
GLU A 583
LEU A 598
GLY A 596
GLY A 582
 None
 1.21A 1httB-1lf9A:
undetectable		 1httB-1lf9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 THR A 646
GLU A 583
LEU A 598
GLY A 596
GLY A 582
 None
 1.18A 1httD-1lf9A:
undetectable		 1httD-1lf9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.12A 1p7lC-1lf9A:
undetectable		 1p7lC-1lf9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.12A 1p7lD-1lf9A:
undetectable		 1p7lD-1lf9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.11A 1rg9A-1lf9A:
undetectable		 1rg9A-1lf9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.12A 1rg9B-1lf9A:
undetectable		 1rg9B-1lf9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.13A 1rg9C-1lf9A:
undetectable		 1rg9C-1lf9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.14A 1rg9D-1lf9A:
undetectable		 1rg9D-1lf9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 ASP A 566
TYR A 574
LEU A 598
GLY A 570
 None
 0.86A 1rmtC-1lf9A:
undetectable		 1rmtC-1lf9A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ALA A 319
ILE A 318
VAL A 348
ALA A 349
PHE A 352
 ACR  A 700 (-3.2A)
None
None
None
None
 0.94A 1uduB-1lf9A:
undetectable		 1uduB-1lf9A:
18.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ULV_A_ACRA3000_1
(GLUCODEXTRANASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		11 / 12 ALA A 319
TYR A 337
TRP A 341
ARG A 343
ASP A 344
GLN A 434
GLU A 439
ASN A 521
ARG A 575
TYR A 581
TRP A 599
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.3A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
ACR  A 700 ( 3.9A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.4A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
None
 0.51A 1ulvA-1lf9A:
53.0		 1ulvA-1lf9A:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ULV_A_ACRA3000_1
(GLUCODEXTRANASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		6 / 12 ARG A 343
GLN A 380
ASN A 521
ARG A 575
TYR A 581
TRP A 599
 ACR  A 700 (-3.6A)
ACR  A 700 (-3.2A)
ACR  A 700 (-3.4A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
None
 1.33A 1ulvA-1lf9A:
53.0		 1ulvA-1lf9A:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 5 GLN A 380
TRP A 437
GLU A 438
LEU A 652
TRP A 654
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.8A)
ACR  A 700 (-3.5A)
None
None
 0.35A 1ulvA-1lf9A:
53.0		 1ulvA-1lf9A:
30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 ARG A 407
SER A 416
TYR A 414
 None
 0.74A 1x70A-1lf9A:
1.4		 1x70A-1lf9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 5 ASP A 673
GLY A 607
ALA A 657
ILE A 661
 None
 0.91A 2aofA-1lf9A:
undetectable		 2aofA-1lf9A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 5 LEU A 652
GLY A 582
PRO A 324
ALA A 649
 None
 0.71A 2aohA-1lf9A:
undetectable		 2aohA-1lf9A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 11 GLY A  39
GLY A 631
GLN A  38
GLU A 630
ILE A 124
 None
 1.29A 2dr2A-1lf9A:
undetectable		 2dr2A-1lf9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ALA A 319
TRP A 341
ARG A 343
ASP A 344
GLY A 392
 ACR  A 700 (-3.2A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
None
 0.59A 2f6dA-1lf9A:
29.5		 2f6dA-1lf9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		10 / 12 ALA A 319
TYR A 337
TRP A 341
ARG A 343
ASP A 344
GLU A 439
ARG A 575
TYR A 581
TRP A 599
GLU A 636
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.3A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
None
None
 0.30A 2f6dA-1lf9A:
29.5		 2f6dA-1lf9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ALA A 319
TYR A 337
TRP A 390
TYR A 581
GLU A 636
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.3A)
ACR  A 700 ( 3.8A)
ACR  A 700 (-3.7A)
None
 0.87A 2f6dA-1lf9A:
29.5		 2f6dA-1lf9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_2
(GLUCOAMYLASE GLU1)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 4 TRP A 437
GLU A 438
LEU A 652
TRP A 654
 ACR  A 700 (-4.8A)
ACR  A 700 (-3.5A)
None
None
 0.46A 2f6dA-1lf9A:
29.5		 2f6dA-1lf9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 7 ASN A 666
THR A 603
GLY A 604
TYR A 620
 None
 1.06A 2f6dA-1lf9A:
29.5		 2f6dA-1lf9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ALA A 319
ILE A 318
VAL A 348
ALA A 349
PHE A 352
 ACR  A 700 (-3.2A)
None
None
None
None
 0.88A 2h42C-1lf9A:
1.0		 2h42C-1lf9A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 SER A  48
THR A 264
SER A 132
ASN A 271
ASN A  45
 None
 1.25A 2nniA-1lf9A:
0.0		 2nniA-1lf9A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.18A 2obvA-1lf9A:
undetectable		 2obvA-1lf9A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.22A 2p02A-1lf9A:
undetectable		 2p02A-1lf9A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 ASP A  30
ASP A 156
GLU A  61
HIS A 158
 None
 0.90A 2q0iA-1lf9A:
undetectable		 2q0iA-1lf9A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 ARG A 436
HIS A 347
ASP A 400
ALA A 446
 None
 1.41A 2rk8A-1lf9A:
3.0		 2rk8A-1lf9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 HIS A 222
SER A 200
ILE A 209
ASP A 212
 None
 1.07A 2v57A-1lf9A:
0.0		 2v57A-1lf9A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 HIS A 222
SER A 200
ILE A 209
ASP A 212
 None
 1.07A 2v57C-1lf9A:
0.0		 2v57C-1lf9A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 4 GLU A 263
ARG A 130
ASN A 131
ASP A 127
 None
 1.50A 2zq9A-1lf9A:
0.0		 2zq9A-1lf9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 5 ILE A  14
TYR A 169
MET A 180
THR A 188
 None
 1.21A 3abkN-1lf9A:
0.5
3abkW-1lf9A:
0.0		 3abkN-1lf9A:
20.80
3abkW-1lf9A:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 GLY A 442
PRO A 430
LEU A 488
 None
 0.54A 3hcpB-1lf9A:
undetectable		 3hcpB-1lf9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 ASP A  68
ASN A 161
SER A 385
 None
 0.87A 3lslA-1lf9A:
0.0
3lslD-1lf9A:
undetectable		 3lslA-1lf9A:
16.49
3lslD-1lf9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 SER A 385
ASP A  68
ASN A 161
 None
 0.96A 3lslA-1lf9A:
0.0
3lslD-1lf9A:
0.0		 3lslA-1lf9A:
16.49
3lslD-1lf9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		6 / 12 ILE A 634
SER A 635
ALA A 655
ILE A 323
TYR A  63
LEU A 321
 None
 1.42A 3mb5A-1lf9A:
undetectable		 3mb5A-1lf9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 6 ALA A 422
ILE A 426
LEU A 455
ALA A 462
 None
 0.89A 3r9sA-1lf9A:
undetectable		 3r9sA-1lf9A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 6 ALA A 422
ILE A 426
LEU A 455
ALA A 462
 None
 0.90A 3r9sC-1lf9A:
undetectable		 3r9sC-1lf9A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 8 TYR A 581
ALA A  35
SER A 322
TYR A 337
SER A 320
 ACR  A 700 (-3.7A)
None
None
ACR  A 700 (-4.3A)
None
 1.31A 3rodA-1lf9A:
undetectable		 3rodA-1lf9A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 9 TYR A 581
ALA A  35
SER A 322
TYR A 337
SER A 320
 ACR  A 700 (-3.7A)
None
None
ACR  A 700 (-4.3A)
None
 1.45A 3rodB-1lf9A:
0.0		 3rodB-1lf9A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 5 ASP A 396
LEU A 395
ILE A 402
PRO A 401
 None
 0.99A 3s3vA-1lf9A:
undetectable		 3s3vA-1lf9A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 4 PHE A 139
TYR A 152
ILE A 124
LEU A 109
 None
 1.15A 3sudA-1lf9A:
0.0		 3sudA-1lf9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 5 PHE A 139
TYR A 152
ILE A 124
LEU A 109
 None
 1.20A 3sueC-1lf9A:
0.0		 3sueC-1lf9A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 THR A 220
ASN A 216
GLY A  82
ALA A 154
GLY A 233
 None
 1.27A 3v3oA-1lf9A:
undetectable		 3v3oA-1lf9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 LYS A 306
GLU A 309
TRP A  51
 None
 1.49A 3v4tH-1lf9A:
0.0		 3v4tH-1lf9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 6 ILE A  14
TYR A 169
MET A 180
THR A 188
 None
 1.19A 3wg7A-1lf9A:
3.4
3wg7J-1lf9A:
undetectable		 3wg7A-1lf9A:
20.80
3wg7J-1lf9A:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 LEU A 190
LEU A 248
LEU A 133
ILE A  75
PHE A  52
 None
 1.06A 4a7aB-1lf9A:
undetectable		 4a7aB-1lf9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 7 GLN A 434
THR A 432
THR A 447
MET A 516
 ACR  A 700 ( 3.9A)
None
None
None
 1.13A 4mbsA-1lf9A:
undetectable		 4mbsA-1lf9A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 6 ILE A 661
ASP A 673
GLY A 604
HIS A 347
 None
 0.97A 4oltB-1lf9A:
undetectable		 4oltB-1lf9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 VAL A 340
TYR A 337
ILE A 304
ILE A 634
SER A 301
 None
ACR  A 700 (-4.3A)
None
None
None
 1.22A 4xudA-1lf9A:
undetectable		 4xudA-1lf9A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 VAL A 340
TYR A 337
ILE A 304
ILE A 634
SER A 301
 None
ACR  A 700 (-4.3A)
None
None
None
 1.27A 4xueA-1lf9A:
undetectable		 4xueA-1lf9A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.21A 5a1iA-1lf9A:
undetectable		 5a1iA-1lf9A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 ASP A 423
SER A 470
TYR A 474
 None
 0.89A 5glmA-1lf9A:
0.0		 5glmA-1lf9A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.15A 5t8sB-1lf9A:
undetectable		 5t8sB-1lf9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 GLU A 605
TRP A 437
HIS A 347
 None
ACR  A 700 (-4.8A)
None
 1.12A 5xipA-1lf9A:
0.0		 5xipA-1lf9A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ILE A 485
LEU A 539
GLY A 454
ALA A 453
LEU A 542
 None
 1.09A 5zwrA-1lf9A:
0.0		 5zwrA-1lf9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 6 GLU A 232
LYS A 182
GLU A 167
ALA A 226
 None
 1.11A 6an0A-1lf9A:
0.8		 6an0A-1lf9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.18A 6fbnB-1lf9A:
undetectable		 6fbnB-1lf9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.20A 6fboA-1lf9A:
undetectable		 6fboA-1lf9A:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.21A 6fcdA-1lf9A:
undetectable		 6fcdA-1lf9A:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_1
(GLUCOAMYLASE P)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		6 / 12 ALA A 319
TRP A 341
ARG A 343
ASP A 344
GLY A 392
TRP A 654
 ACR  A 700 (-3.2A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
None
None
 0.83A 6fhwA-1lf9A:
29.4		 6fhwA-1lf9A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_1
(GLUCOAMYLASE P)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ALA A 319
TRP A 341
ASP A 344
GLU A 435
TRP A 654
 ACR  A 700 (-3.2A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
None
None
 1.20A 6fhwA-1lf9A:
29.4		 6fhwA-1lf9A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_1
(GLUCOAMYLASE P)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		10 / 12 ALA A 319
TYR A 337
TRP A 341
ARG A 343
ASP A 344
GLU A 439
ARG A 575
TYR A 581
TRP A 599
TRP A 654
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.3A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
None
None
 0.45A 6fhwA-1lf9A:
29.4		 6fhwA-1lf9A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_1
(GLUCOAMYLASE P)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ALA A 319
TYR A 337
TRP A 390
GLU A 439
TYR A 581
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.3A)
ACR  A 700 ( 3.8A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.7A)
 0.91A 6fhwA-1lf9A:
29.4		 6fhwA-1lf9A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 TRP A 437
GLU A 438
GLU A 636
 ACR  A 700 (-4.8A)
ACR  A 700 (-3.5A)
None
 0.37A 6fhwA-1lf9A:
29.4		 6fhwA-1lf9A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 TRP A 654
GLU A 636
GLU A 438
 None
None
ACR  A 700 (-3.5A)
 0.88A 6fhwA-1lf9A:
29.4		 6fhwA-1lf9A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_1
(GLUCOAMYLASE P)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		6 / 12 ALA A 319
TRP A 341
ARG A 343
ASP A 344
GLY A 392
TRP A 654
 ACR  A 700 (-3.2A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
None
None
 0.83A 6fhwB-1lf9A:
29.5		 6fhwB-1lf9A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_1
(GLUCOAMYLASE P)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ALA A 319
TRP A 341
ASP A 344
GLU A 435
TRP A 654
 ACR  A 700 (-3.2A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
None
None
 1.20A 6fhwB-1lf9A:
29.5		 6fhwB-1lf9A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_1
(GLUCOAMYLASE P)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		10 / 12 ALA A 319
TYR A 337
TRP A 341
ARG A 343
ASP A 344
GLU A 439
ARG A 575
TYR A 581
TRP A 599
TRP A 654
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.3A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.7A)
None
None
 0.45A 6fhwB-1lf9A:
29.5		 6fhwB-1lf9A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_1
(GLUCOAMYLASE P)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ALA A 319
TYR A 337
TRP A 390
GLU A 439
TYR A 581
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.3A)
ACR  A 700 ( 3.8A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.7A)
 0.91A 6fhwB-1lf9A:
29.5		 6fhwB-1lf9A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_2
(GLUCOAMYLASE P)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 4 TRP A 437
GLU A 438
GLU A 636
LEU A 652
 ACR  A 700 (-4.8A)
ACR  A 700 (-3.5A)
None
None
 0.49A 6fhwB-1lf9A:
29.5		 6fhwB-1lf9A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 ASP A  30
HIS A 591
HIS A 158
ASP A 327
 None
 1.25A 6mn4B-1lf9A:
0.0		 6mn4B-1lf9A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1lf9 GLUCOAMYLASE
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 ASP A  30
HIS A 591
HIS A 158
ASP A 327
 None
 1.23A 6mn4D-1lf9A:
undetectable		 6mn4D-1lf9A:
16.74