SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 10 LEU A 164
VAL A 173
TYR A 417
GLY A  83
LEU A 420
 None
 1.41A 1fk9A-1lfwA:
2.9		 1fk9A-1lfwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 8 LEU A 164
PRO A 176
VAL A 173
GLY A  83
 None
 1.04A 1hrkA-1lfwA:
2.6		 1hrkA-1lfwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 8 LEU A 164
PRO A 176
VAL A 173
GLY A  83
 None
 1.02A 1hrkB-1lfwA:
undetectable		 1hrkB-1lfwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 6 LEU A 149
PHE A 147
TYR A 457
VAL A  73
 None
 1.30A 1ibgH-1lfwA:
undetectable		 1ibgH-1lfwA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 9 LEU A 164
VAL A 173
TYR A 417
GLY A  83
LEU A 420
 None
 1.43A 1ikvA-1lfwA:
2.2		 1ikvA-1lfwA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 10 LEU A 164
VAL A 173
TYR A 417
GLY A  83
LEU A 420
 None
 1.42A 1ikwA-1lfwA:
2.5		 1ikwA-1lfwA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_B_KANB2300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 9 ASP A 467
ASP A 389
ARG A 423
GLU A 463
GLU A 468
 None
 1.21A 1nd4B-1lfwA:
0.8		 1nd4B-1lfwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		3 / 3 ILE A 261
ILE A 227
THR A 223
 None
 0.63A 1rg7A-1lfwA:
undetectable		 1rg7A-1lfwA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 8 LYS A 209
LEU A 207
PHE A 292
LEU A 300
 None
 0.92A 2eilP-1lfwA:
undetectable
2eilW-1lfwA:
undetectable		 2eilP-1lfwA:
19.87
2eilW-1lfwA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 7 ALA A 280
THR A 281
ALA A 284
PRO A 332
 None
 0.96A 2ql8A-1lfwA:
0.6
2ql8B-1lfwA:
0.0		 2ql8A-1lfwA:
14.04
2ql8B-1lfwA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 PHE A 368
PHE A 194
LEU A 345
PHE A 335
 None
 1.34A 2y69P-1lfwA:
0.3
2y69W-1lfwA:
0.0		 2y69P-1lfwA:
19.87
2y69W-1lfwA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 PHE A 368
PHE A 194
LEU A 345
PHE A 335
 None
 1.32A 3abmP-1lfwA:
0.2
3abmW-1lfwA:
0.0		 3abmP-1lfwA:
19.87
3abmW-1lfwA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 8 LYS A 209
LEU A 207
PHE A 292
LEU A 300
 None
 0.96A 3asoC-1lfwA:
undetectable
3asoJ-1lfwA:
undetectable		 3asoC-1lfwA:
19.87
3asoJ-1lfwA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 VAL A 410
VAL A 411
PHE A 427
ARG A 350
 None
None
None
AEP  A 683 (-2.8A)
 1.25A 3bjwH-1lfwA:
0.0		 3bjwH-1lfwA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 6 PHE A 444
ASP A 107
TYR A 113
PRO A 435
 None
 1.44A 3jqaA-1lfwA:
undetectable		 3jqaA-1lfwA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 6 PHE A 444
ASP A 107
TYR A 113
PRO A 435
 None
 1.44A 3jqaB-1lfwA:
undetectable		 3jqaB-1lfwA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 6 PHE A 444
ASP A 107
TYR A 113
PRO A 435
 None
 1.47A 3jqaC-1lfwA:
undetectable		 3jqaC-1lfwA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 6 PHE A 444
ASP A 107
TYR A 113
PRO A 435
 None
 1.45A 3jqaD-1lfwA:
undetectable		 3jqaD-1lfwA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 7 GLU A 380
LEU A 420
ARG A 419
THR A 416
 None
 1.30A 3mbgA-1lfwA:
0.0
3mbgB-1lfwA:
0.0		 3mbgA-1lfwA:
12.13
3mbgB-1lfwA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 12 GLY A 267
GLY A 276
SER A 331
ASN A 217
VAL A 218
 None
None
None
AEP  A 683 (-3.6A)
None
 1.09A 3nk7A-1lfwA:
undetectable		 3nk7A-1lfwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 LEU A 316
GLY A 317
PHE A 368
PHE A 302
 None
 1.19A 3smtA-1lfwA:
undetectable		 3smtA-1lfwA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 9 LEU A 164
VAL A 173
TYR A 417
GLY A  83
LEU A 420
 None
 1.44A 4b3oA-1lfwA:
2.3		 4b3oA-1lfwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 6 HIS A 269
GLU A 179
ASP A 449
ASP A 119
 AEP  A 683 (-4.0A)
None
None
ZN  A1001 (-2.4A)
 1.39A 4blvA-1lfwA:
undetectable		 4blvA-1lfwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 LEU A  17
LEU A  20
MET A 445
THR A 126
 None
 1.20A 4do3A-1lfwA:
0.0		 4do3A-1lfwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 ARG A  58
TYR A 129
TYR A 128
LEU A 125
 None
 1.37A 4f8yA-1lfwA:
1.6
4f8yB-1lfwA:
1.5		 4f8yA-1lfwA:
16.98
4f8yB-1lfwA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 ARG A  58
TYR A 129
TYR A 128
LEU A 125
 None
 1.39A 4f8yC-1lfwA:
1.6
4f8yD-1lfwA:
1.4		 4f8yC-1lfwA:
16.98
4f8yD-1lfwA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 7 ASP A 119
GLU A 154
HIS A 439
GLU A 153
 ZN  A1001 (-2.4A)
ZN  A1001 ( 1.9A)
ZN  A1001 ( 3.1A)
AEP  A 683 (-2.7A)
 1.03A 4hvrA-1lfwA:
undetectable		 4hvrA-1lfwA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		3 / 3 LYS A 211
ASN A 278
ASP A 336
 None
 0.90A 4o1eA-1lfwA:
undetectable		 4o1eA-1lfwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 TYR A 129
LYS A  12
LEU A 133
GLU A 136
 None
 1.26A 4olbA-1lfwA:
0.0		 4olbA-1lfwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		6 / 11 HIS A  87
ASP A 119
GLU A 153
GLU A 154
GLY A 413
HIS A 439
 ZN  A1002 ( 3.2A)
ZN  A1001 (-2.4A)
AEP  A 683 (-2.7A)
ZN  A1001 ( 1.9A)
None
ZN  A1001 ( 3.1A)
 0.58A 4pqaA-1lfwA:
29.9		 4pqaA-1lfwA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		6 / 11 HIS A  87
GLU A 153
GLU A 154
GLY A 413
GLY A 414
HIS A 439
 ZN  A1002 ( 3.2A)
AEP  A 683 (-2.7A)
ZN  A1001 ( 1.9A)
None
AEP  A 683 (-3.6A)
ZN  A1001 ( 3.1A)
 1.03A 4pqaA-1lfwA:
29.9		 4pqaA-1lfwA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 12 LEU A 283
GLY A 265
GLY A 267
ASN A 278
GLU A  95
 None
 1.16A 4x61A-1lfwA:
undetectable		 4x61A-1lfwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 10 GLY A 150
ASP A 120
ALA A 127
PRO A 176
LEU A 149
 None
ZN  A1002 ( 4.8A)
None
None
None
 1.11A 4xj7A-1lfwA:
undetectable
4xj7B-1lfwA:
undetectable		 4xj7A-1lfwA:
21.14
4xj7B-1lfwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 10 LEU A 149
GLY A 150
ASP A 120
ALA A 127
PRO A 176
 None
None
ZN  A1002 ( 4.8A)
None
None
 1.16A 4xj7C-1lfwA:
undetectable
4xj7D-1lfwA:
undetectable		 4xj7C-1lfwA:
21.14
4xj7D-1lfwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 7 LYS A 209
LEU A 207
PHE A 292
LEU A 300
 None
 0.96A 5b3sP-1lfwA:
0.1		 5b3sP-1lfwA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 7 ALA A 460
ASP A 389
ARG A 423
GLY A 424
 None
 0.88A 5btgA-1lfwA:
2.9
5btgC-1lfwA:
2.8
5btgD-1lfwA:
2.5		 5btgA-1lfwA:
23.33
5btgC-1lfwA:
23.33
5btgD-1lfwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 6 VAL A 235
ASP A 231
PRO A 230
ALA A 234
 None
 0.87A 5cu6A-1lfwA:
undetectable		 5cu6A-1lfwA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 12 LEU A 447
GLY A 110
ARG A 111
TYR A 113
LEU A  17
 None
 1.20A 5czyA-1lfwA:
0.0		 5czyA-1lfwA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 PRO A 220
HIS A 308
LEU A 207
TYR A 239
 None
 1.20A 5igjA-1lfwA:
0.8		 5igjA-1lfwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 11 ILE A 261
PHE A 286
LEU A 283
ALA A 284
LEU A 232
 None
 1.21A 5ji0A-1lfwA:
undetectable		 5ji0A-1lfwA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 TYR A 129
LYS A  12
LEU A 133
GLU A 136
 None
 1.21A 5js1A-1lfwA:
0.0		 5js1A-1lfwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 8 HIS A  87
LEU A 420
GLY A 418
SER A 175
 ZN  A1002 ( 3.2A)
None
None
None
 1.03A 5m8rC-1lfwA:
0.0		 5m8rC-1lfwA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 TYR A 457
SER A 175
ALA A 426
GLN A 430
 None
 1.08A 5n0wB-1lfwA:
0.3		 5n0wB-1lfwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 TYR A 457
SER A 175
ALA A 426
GLN A 430
 None
 1.08A 5n4iA-1lfwA:
undetectable		 5n4iA-1lfwA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 VAL A 235
ASP A 231
PRO A 230
ALA A 234
 None
 0.87A 5otrA-1lfwA:
undetectable		 5otrA-1lfwA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		3 / 3 LEU A 396
ILE A 182
TYR A 384
 None
 0.53A 5uunB-1lfwA:
0.0		 5uunB-1lfwA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 PHE A 368
PHE A 194
LEU A 345
PHE A 335
 None
 1.33A 5wauC-1lfwA:
0.3
5wauJ-1lfwA:
0.0		 5wauC-1lfwA:
19.87
5wauJ-1lfwA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 PHE A 368
PHE A 194
LEU A 345
PHE A 335
 None
 1.33A 5wauc-1lfwA:
0.3
5wauj-1lfwA:
0.0		 5wauc-1lfwA:
19.87
5wauj-1lfwA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 4 TYR A 351
ARG A 350
THR A 191
LEU A 192
 None
AEP  A 683 (-2.8A)
None
None
 1.48A 5wauj-1lfwA:
0.0		 5wauj-1lfwA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 PHE A 368
PHE A 194
LEU A 345
PHE A 335
 None
 1.30A 5xdqC-1lfwA:
0.1
5xdqJ-1lfwA:
0.0		 5xdqC-1lfwA:
19.87
5xdqJ-1lfwA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 PHE A 368
PHE A 194
LEU A 345
PHE A 335
 None
 1.31A 5xdqP-1lfwA:
0.3
5xdqW-1lfwA:
0.0		 5xdqP-1lfwA:
19.87
5xdqW-1lfwA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 6 LEU A 263
LYS A 236
GLU A 240
LEU A 243
 None
 1.23A 5xooA-1lfwA:
0.0		 5xooA-1lfwA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 12 LEU A  32
VAL A  41
GLY A  42
PHE A 102
ASN A 152
 None
 1.39A 6a94A-1lfwA:
undetectable		 6a94A-1lfwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 1lfw PEPV
(Lactobacillus
delbrueckii) 		3 / 3 GLU A 422
ASP A 389
PRO A 386
 None
 0.75A 6berA-1lfwA:
undetectable		 6berA-1lfwA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 10 LEU A 164
VAL A 173
TYR A 417
GLY A  83
LEU A 420
 None
 1.46A 6bsgA-1lfwA:
2.5		 6bsgA-1lfwA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 10 LEU A 164
VAL A 173
TYR A 417
GLY A  83
LEU A 420
 None
 1.44A 6bsjA-1lfwA:
2.2		 6bsjA-1lfwA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 12 GLY A 116
VAL A  91
GLY A 110
ASP A 107
GLN A 430
 None
 1.12A 6gngA-1lfwA:
3.2		 6gngA-1lfwA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 11 SER A 271
GLY A 116
ALA A  48
ASN A 217
VAL A  91
 None
None
None
AEP  A 683 (-3.6A)
None
 1.29A 6hu9A-1lfwA:
0.1
6hu9E-1lfwA:
0.2
6hu9I-1lfwA:
0.0		 6hu9A-1lfwA:
23.11
6hu9E-1lfwA:
17.15
6hu9I-1lfwA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 10 SER A 271
GLY A 116
ALA A  48
ASN A 217
VAL A  91
 None
None
None
AEP  A 683 (-3.6A)
None
 1.36A 6hu9L-1lfwA:
0.0
6hu9P-1lfwA:
0.0
6hu9T-1lfwA:
0.0		 6hu9L-1lfwA:
23.11
6hu9P-1lfwA:
17.15
6hu9T-1lfwA:
9.19