SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lgf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		3 / 3 LEU A 247
SER A 242
ASN A 240
 None
None
HEM  A 430 (-3.9A)
 0.82A 1bx4A-1lgfA:
undetectable		 1bx4A-1lgfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 7 THR A  63
SER A  62
HIS A 345
LEU A 348
 None
None
HEM  A 430 (-3.8A)
HEM  A 430 ( 4.4A)
 1.10A 1ibgL-1lgfA:
0.0		 1ibgL-1lgfA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 11 LEU A 276
GLY A 248
GLY A 246
VAL A 143
LEU A 139
 None
 1.11A 1mx1A-1lgfA:
undetectable		 1mx1A-1lgfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		3 / 3 LEU A 357
VAL A 360
LEU A 364
 None
 0.49A 1mz9B-1lgfA:
undetectable		 1mz9B-1lgfA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 5 LEU A 195
ASP A 223
GLY A 218
ALA A 199
ILE A 198
 None
 1.34A 2aohB-1lgfA:
undetectable		 2aohB-1lgfA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 7 LEU A 297
LEU A  28
PRO A 286
ARG A 289
 None
None
HEM  A 430 (-4.5A)
HEM  A 430 (-3.0A)
 1.01A 2jn3A-1lgfA:
undetectable		 2jn3A-1lgfA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 9 GLY A 157
THR A 359
VAL A 151
ILE A 122
VAL A 123
 None
 1.19A 2nnhB-1lgfA:
29.2		 2nnhB-1lgfA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 MET A  44
THR A  46
ALA A 315
ILE A  11
LEU A  22
 None
 1.14A 2qxsA-1lgfA:
1.0		 2qxsA-1lgfA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 MET A  44
THR A  46
ALA A 315
ILE A  11
LEU A  22
 None
 1.10A 2qxsB-1lgfA:
undetectable		 2qxsB-1lgfA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		6 / 12 LEU A 195
ASP A 223
ILE A 210
GLY A 218
ALA A 199
ILE A 198
 None
 1.41A 2rkfB-1lgfA:
undetectable		 2rkfB-1lgfA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		6 / 12 LEU A 195
ASP A 223
ILE A 210
VAL A 213
GLY A 218
ILE A 198
 None
 1.29A 2rkgA-1lgfA:
undetectable		 2rkgA-1lgfA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 152
ALA A 353
GLY A 349
GLY A 237
ASP A 238
 None
HEM  A 430 ( 3.9A)
HEM  A 430 ( 3.9A)
HEM  A 430 (-3.3A)
None
 1.21A 3ou7A-1lgfA:
undetectable		 3ou7A-1lgfA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 GLY A 246
ASP A 138
ILE A 140
GLY A 390
PHE A 382
 None
 1.17A 3ps9A-1lgfA:
undetectable		 3ps9A-1lgfA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 10 THR A 380
LEU A 373
VAL A 396
LEU A 391
PHE A 382
 None
 1.34A 3tbgC-1lgfA:
10.4		 3tbgC-1lgfA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 7 GLY A 228
PHE A 166
PHE A 190
LEU A 194
 None
 0.77A 3v7pA-1lgfA:
undetectable		 3v7pA-1lgfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 6 MET A 244
LEU A 280
PRO A  18
TYR A 279
 None
 0.95A 3vkxA-1lgfA:
undetectable		 3vkxA-1lgfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 5 GLU A 207
GLY A 208
TYR A 118
GLU A 154
 None
 1.32A 3w9tC-1lgfA:
0.0		 3w9tC-1lgfA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 5 GLU A 207
GLY A 208
TYR A 118
GLU A 154
 None
 1.32A 3w9tD-1lgfA:
undetectable		 3w9tD-1lgfA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 6 ILE A 140
ASP A 145
GLY A 390
VAL A 282
 None
 1.05A 4oltA-1lgfA:
0.0		 4oltA-1lgfA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		3 / 3 PHE A 361
THR A 380
LEU A 280
 None
 0.75A 4qztA-1lgfA:
0.0		 4qztA-1lgfA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 GLY A 349
ILE A 210
MET A 209
GLY A 106
PHE A 107
 HEM  A 430 ( 3.9A)
None
None
None
None
 1.04A 4r29D-1lgfA:
0.0		 4r29D-1lgfA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		6 / 12 CYH A 230
LEU A 226
LYS A 102
LEU A 103
THR A 108
VAL A 156
 None
 1.46A 4x1iB-1lgfA:
undetectable		 4x1iB-1lgfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 6 ARG A 367
ARG A 126
ASP A 128
VAL A 360
 None
 1.13A 4xqeA-1lgfA:
undetectable		 4xqeA-1lgfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 8 ILE A 309
VAL A  51
LEU A 312
THR A 281
 None
 0.78A 5og9A-1lgfA:
31.9		 5og9A-1lgfA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		3 / 3 GLN A 300
TRP A  43
VAL A 308
 None
 0.66A 6auuA-1lgfA:
0.0		 6auuA-1lgfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 5 TYR A 217
LYS A 102
LEU A 226
GLU A 225
 None
 1.45A 6cbdA-1lgfA:
undetectable		 6cbdA-1lgfA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 5 GLU A 356
VAL A 151
LEU A 152
HIS A 171
 None
 1.10A 6dyoA-1lgfA:
0.0		 6dyoA-1lgfA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 5 LEU A 235
THR A 386
PRO A 148
ARG A 126
 None
 1.27A 6ew0B-1lgfA:
0.0		 6ew0B-1lgfA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 5 LEU A 235
THR A 386
PRO A 148
ARG A 126
 None
 1.27A 6ew0D-1lgfA:
0.0		 6ew0D-1lgfA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 5 LEU A 235
THR A 386
PRO A 148
ARG A 126
 None
 1.27A 6ew0H-1lgfA:
0.0		 6ew0H-1lgfA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 1lgf P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 5 LEU A 235
THR A 386
PRO A 148
ARG A 126
 None
 1.27A 6ew0I-1lgfA:
0.0		 6ew0I-1lgfA:
14.70