SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		4 / 7 PHE A 173
SER A 223
ALA A  21
PHE A 261
 None
 1.20A 1fxvA-1lgyA:
undetectable
1fxvB-1lgyA:
0.0		 1fxvA-1lgyA:
19.30
1fxvB-1lgyA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		3 / 3 ARG A 203
VAL A 200
TRP A 224
 None
 0.97A 1qw6A-1lgyA:
0.0		 1qw6A-1lgyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		3 / 3 ARG A 203
VAL A 200
TRP A 224
 None
 1.04A 1qwcA-1lgyA:
0.0		 1qwcA-1lgyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		3 / 3 ARG A 203
VAL A 200
TRP A 224
 None
 1.03A 1vagA-1lgyA:
undetectable		 1vagA-1lgyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		3 / 3 ARG A 198
SER A 115
TYR A 116
 None
 0.66A 1x70A-1lgyA:
5.0		 1x70A-1lgyA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		3 / 3 ARG A 203
VAL A 200
TRP A 224
 None
 1.10A 1zviA-1lgyA:
0.0		 1zviA-1lgyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		6 / 10 SER A 115
ALA A 149
PHE A  80
ALA A 154
LEU A 158
LEU A  78
 None
 1.36A 2bxqA-1lgyA:
undetectable		 2bxqA-1lgyA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_2
(NEURAMINIDASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		4 / 4 ASP A 204
TRP A 224
ILE A 248
ARG A 203
 None
 1.36A 2htqA-1lgyA:
undetectable		 2htqA-1lgyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		4 / 6 TYR A  77
TRP A  38
TYR A  66
ILE A  52
 None
 1.47A 2pgzD-1lgyA:
0.0
2pgzE-1lgyA:
0.0		 2pgzD-1lgyA:
19.93
2pgzE-1lgyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		4 / 9 PHE A 185
ALA A 186
VAL A 189
GLU A 190
 None
 0.47A 2vufA-1lgyA:
undetectable		 2vufA-1lgyA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		4 / 5 GLN A  15
ALA A  12
GLN A  13
ILE A  14
 None
 1.49A 2z0aA-1lgyA:
undetectable		 2z0aA-1lgyA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 ARG A 179
GLU A 240
PHE A 196
ASN A 246
HIS A 208
 None
 1.16A 3bjmB-1lgyA:
4.8		 3bjmB-1lgyA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		4 / 4 LEU A 146
GLY A 147
GLY A  82
THR A  63
 None
 0.81A 3si7A-1lgyA:
0.6		 3si7A-1lgyA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 LEU A 152
GLU A 190
VAL A 189
PRO A 219
SER A 245
 None
 1.23A 4hvcB-1lgyA:
undetectable		 4hvcB-1lgyA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 GLY A 143
GLY A 148
GLY A 147
PHE A  86
GLY A 177
 None
 0.82A 4o3fA-1lgyA:
undetectable		 4o3fA-1lgyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 LEU A 152
GLU A 190
VAL A 189
PRO A 219
SER A 245
 None
 1.24A 4q15A-1lgyA:
undetectable		 4q15A-1lgyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 LEU A 152
GLU A 190
VAL A 189
PRO A 219
SER A 245
 None
 1.24A 4q15B-1lgyA:
undetectable		 4q15B-1lgyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		3 / 3 ASP A 243
ARG A 179
ARG A 198
 None
 0.87A 4x5iA-1lgyA:
0.0		 4x5iA-1lgyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 PHE A  80
VAL A 139
ALA A 154
ILE A 172
ILE A 140
 None
 0.98A 4xdrA-1lgyA:
0.0		 4xdrA-1lgyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 LEU A 152
GLU A 190
VAL A 189
PRO A 219
SER A 245
 None
 1.22A 4ydqA-1lgyA:
undetectable		 4ydqA-1lgyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		3 / 3 ASP A 243
ARG A 179
ARG A 198
 None
 0.95A 5eajB-1lgyA:
0.0		 5eajB-1lgyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 LEU A 152
GLU A 190
VAL A 189
PRO A 219
SER A 245
 None
 1.31A 5f9zA-1lgyA:
undetectable		 5f9zA-1lgyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 LEU A 152
GLY A 220
GLU A 190
VAL A 189
SER A 245
 None
 1.34A 5f9zA-1lgyA:
undetectable		 5f9zA-1lgyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 LEU A 152
GLU A 190
VAL A 189
PRO A 219
SER A 245
 None
 1.26A 5f9zB-1lgyA:
undetectable		 5f9zB-1lgyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		3 / 3 ARG A 203
VAL A 200
TRP A 224
 None
 1.09A 5fvoA-1lgyA:
0.0		 5fvoA-1lgyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 HIS A 257
GLY A 176
HIS A 144
VAL A  33
GLY A 148
 None
 1.08A 5hg0B-1lgyA:
undetectable		 5hg0B-1lgyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		3 / 3 ARG A 198
HIS A 208
ARG A 179
 None
 1.17A 5iaoF-1lgyA:
0.9		 5iaoF-1lgyA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		4 / 7 PHE A  86
GLY A  82
GLY A 147
HIS A 144
 None
 0.93A 5n9xA-1lgyA:
undetectable		 5n9xA-1lgyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 LEU A 152
GLU A 190
VAL A 189
PRO A 219
SER A 245
 None
 1.25A 5xipA-1lgyA:
undetectable		 5xipA-1lgyA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 LEU A 152
GLU A 190
VAL A 189
PRO A 219
SER A 245
 None
 1.23A 5xiqA-1lgyA:
undetectable		 5xiqA-1lgyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 LEU A 152
GLU A 190
VAL A 189
PRO A 219
SER A 245
 None
 1.27A 5xiqB-1lgyA:
undetectable		 5xiqB-1lgyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		3 / 3 ALA A 151
VAL A 119
TYR A 116
 None
 0.65A 5zmqH-1lgyA:
undetectable		 5zmqH-1lgyA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 GLY A 148
ALA A 149
GLY A 155
LEU A 113
VAL A 180
 None
 1.03A 6dh0B-1lgyA:
undetectable		 6dh0B-1lgyA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		4 / 5 GLY A 155
LEU A 152
TYR A 188
GLN A 160
 None
 1.29A 6ji6A-1lgyA:
undetectable		 6ji6A-1lgyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 1lgy TRIACYLGLYCEROL
LIPASE
(Rhizopus
niveus) 		5 / 12 LEU A 152
GLU A 190
VAL A 189
PRO A 219
SER A 245
 None
 1.29A 6mn8A-1lgyA:
undetectable		 6mn8A-1lgyA:
20.23