SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lhu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 1lhu SEX HORMONE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 6 HIS A 101
ASP A  96
ASP A  50
PRO A  76
 None
None
CA  A 401 (-2.1A)
None
 1.39A 1ilqA-1lhuA:
undetectable
1ilqC-1lhuA:
undetectable		 1ilqA-1lhuA:
18.54
1ilqC-1lhuA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1lhu SEX HORMONE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 7 VAL A  89
LEU A 124
SER A 111
LEU A 113
 None
 0.89A 1j8uA-1lhuA:
undetectable		 1j8uA-1lhuA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1lhu SEX HORMONE-BINDING
GLOBULIN
(Homo
sapiens) 		8 / 8 SER A  42
THR A  60
ASP A  65
PHE A  67
ASN A  82
MET A 107
MET A 139
LEU A 171
 EST  A 301 (-2.7A)
None
EST  A 301 (-2.9A)
EST  A 301 (-4.0A)
EST  A 301 (-3.9A)
EST  A 301 ( 3.9A)
EST  A 301 ( 3.9A)
None
 0.62A 1lhvA-1lhuA:
34.1		 1lhvA-1lhuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1lhu SEX HORMONE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 10 GLY A 145
VAL A  54
TRP A  66
LEU A 157
LEU A 153
 None
 1.31A 1pbcA-1lhuA:
undetectable		 1pbcA-1lhuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1lhu SEX HORMONE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 8 ILE A  55
ARG A 166
ILE A 141
VAL A  46
 None
None
EST  A 301 (-4.5A)
None
 0.69A 2nniA-1lhuA:
undetectable		 2nniA-1lhuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 1lhu SEX HORMONE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A 183
SER A 184
ARG A 186
 None
 0.76A 3phnA-1lhuA:
0.0		 3phnA-1lhuA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1lhu SEX HORMONE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 12 SER A 111
VAL A 112
ILE A  78
PHE A  67
HIS A  81
 None
None
None
EST  A 301 (-4.0A)
None
 1.11A 4c49D-1lhuA:
0.0		 4c49D-1lhuA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1lhu SEX HORMONE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 8 ASN A  82
VAL A 112
LEU A 124
ILE A  78
 EST  A 301 (-3.9A)
None
None
None
 0.81A 4r38D-1lhuA:
undetectable		 4r38D-1lhuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 1lhu SEX HORMONE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 5 ASP A  65
TRP A  84
VAL A 127
ALA A  85
 EST  A 301 (-2.9A)
None
None
None
 1.16A 5dl9A-1lhuA:
undetectable		 5dl9A-1lhuA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1lhu SEX HORMONE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 4 ASP A 168
ILE A  27
PRO A  26
LEU A 143
 None
 1.41A 6mkeB-1lhuA:
0.0		 6mkeB-1lhuA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1lhu SEX HORMONE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 4 ASP A 168
ILE A  27
PRO A  26
LEU A 143
 None
 1.40A 6mkeA-1lhuA:
0.0		 6mkeA-1lhuA:
16.40