SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1li7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 PHE A  44
GLY A 225
HIS A 235
GLU A 238
HIS A 234
 None
None
None
ZN  A 963 (-3.8A)
ZN  A 963 ( 3.1A)
 1.49A 1a4lD-1li7A:
undetectable		 1a4lD-1li7A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 HIS A  37
GLY A  39
GLY A 227
ASP A 229
VAL A 260
 None
 0.57A 1ffyA-1li7A:
20.5		 1ffyA-1li7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A   8
GLY A 227
GLY A 226
THR A   7
LEU A 155
 None
 1.07A 1liiA-1li7A:
2.7		 1liiA-1li7A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLU A 238
HIS A 235
HIS A 234
 ZN  A 963 (-3.8A)
None
ZN  A 963 ( 3.1A)
 0.66A 1oe2A-1li7A:
0.0		 1oe2A-1li7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 HIS A  37
GLY A  39
GLY A 227
ASP A 229
VAL A 260
 None
 0.57A 1qu2A-1li7A:
20.5		 1qu2A-1li7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 SER A 300
LEU A 302
GLY A  39
ILE A 105
 None
 0.71A 2bdmA-1li7A:
undetectable		 2bdmA-1li7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 PHE A 350
ALA A 355
LEU A 359
LEU A 391
VAL A  49
 None
 1.09A 2bxeA-1li7A:
undetectable		 2bxeA-1li7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 ILE A   4
VAL A 251
PHE A 221
LEU A 217
ILE A  18
 None
 1.22A 2h42A-1li7A:
0.0		 2h42A-1li7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ALA A 322
LEU A 394
LEU A 359
PHE A 360
SER A 357
 None
 1.05A 2oipE-1li7A:
undetectable		 2oipE-1li7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 LEU A 106
MET A 294
MET A 346
LEU A 391
 None
 1.03A 2oz7A-1li7A:
undetectable		 2oz7A-1li7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 GLU A 365
ALA A 322
LEU A 319
THR A 321
 None
 1.09A 2roxB-1li7A:
undetectable		 2roxB-1li7A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 9 ALA A  46
VAL A  50
GLY A 226
GLY A 225
ILE A   4
 None
 0.76A 2z0yB-1li7A:
undetectable		 2z0yB-1li7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 HIS A 234
ASP A  69
THR A  68
HIS A 224
 ZN  A 963 ( 3.1A)
None
CYS  A1000 (-3.3A)
None
 1.42A 3ag1A-1li7A:
0.0
3ag1C-1li7A:
0.0		 3ag1A-1li7A:
21.22
3ag1C-1li7A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 HIS A 234
ASP A  69
THR A  68
HIS A 224
 ZN  A 963 ( 3.1A)
None
CYS  A1000 (-3.3A)
None
 1.41A 3ag4N-1li7A:
0.0
3ag4P-1li7A:
undetectable		 3ag4N-1li7A:
21.22
3ag4P-1li7A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ALA A 322
LEU A 394
LEU A 359
PHE A 360
SER A 357
 None
 1.19A 3hj3A-1li7A:
undetectable		 3hj3A-1li7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ALA A 322
LEU A 394
LEU A 359
PHE A 360
SER A 357
 None
 1.07A 3hj3C-1li7A:
undetectable		 3hj3C-1li7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 LEU A 391
ARG A  52
ALA A  51
GLY A 296
 None
 0.87A 3ny4A-1li7A:
undetectable		 3ny4A-1li7A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 4 ASP A  72
ASP A  71
GLY A 204
THR A 115
 None
 1.01A 3tl9B-1li7A:
undetectable		 3tl9B-1li7A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 PRO A  17
ASP A 222
GLU A  22
 None
 0.81A 3v4tC-1li7A:
0.0		 3v4tC-1li7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 12 HIS A  40
ASP A 229
HIS A 256
GLY A 258
GLY A  39
HIS A 297
 None
 1.48A 4blvB-1li7A:
1.4		 4blvB-1li7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ALA A  46
VAL A  50
THR A   7
ILE A 223
HIS A 256
 None
 1.16A 4c49A-1li7A:
0.0		 4c49A-1li7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 4 PHE A  44
HIS A  40
GLY A  29
ILE A  30
 None
None
CYS  A1000 (-4.3A)
CYS  A1000 (-4.9A)
 1.27A 4k50E-1li7A:
0.0		 4k50E-1li7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 4 PHE A  44
HIS A  40
GLY A  29
ILE A  30
 None
None
CYS  A1000 (-4.3A)
CYS  A1000 (-4.9A)
 1.26A 4k50M-1li7A:
0.0		 4k50M-1li7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 VAL A  49
LEU A 391
SER A 388
GLU A 395
 None
 1.06A 4zphA-1li7A:
0.0
4zphB-1li7A:
undetectable		 4zphA-1li7A:
17.86
4zphB-1li7A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 VAL A 280
LEU A 293
MET A 267
VAL A 260
 None
 1.02A 5e4dA-1li7A:
undetectable
5e4dB-1li7A:
undetectable		 5e4dA-1li7A:
17.03
5e4dB-1li7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 THR A  43
VAL A  45
VAL A 260
HIS A  40
 None
 0.85A 5eckA-1li7A:
1.2		 5eckA-1li7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 THR A  43
VAL A  45
VAL A 260
HIS A  40
 None
 0.79A 5eckD-1li7A:
0.4		 5eckD-1li7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A  47
VAL A  50
ILE A   4
ASP A 349
 None
 0.97A 5iwuA-1li7A:
undetectable		 5iwuA-1li7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ILE A  70
ALA A 114
ILE A 121
ILE A 118
 None
 0.70A 5mvmA-1li7A:
2.3
5mvmB-1li7A:
2.3		 5mvmA-1li7A:
11.17
5mvmB-1li7A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A  57
PHE A 342
ARG A  55
GLY A 392
LEU A 391
 None
 1.26A 5ogcB-1li7A:
2.9		 5ogcB-1li7A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 GLU A 397
PRO A 398
GLN A 396
LEU A 323
 None
 0.85A 5w3jB-1li7A:
undetectable		 5w3jB-1li7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 THR A  68
GLU A 208
HIS A 206
 CYS  A1000 (-3.3A)
CYS  A1000 ( 4.9A)
None
 0.90A 5xiqD-1li7A:
2.2		 5xiqD-1li7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 ALA A 211
VAL A  64
TYR A  26
 None
 0.61A 5zmqH-1li7A:
undetectable		 5zmqH-1li7A:
15.16