SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lia'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 12 ALA B 121
VAL B 124
GLY B 123
ALA B  83
ILE B  56
 None
CYC  B 175 ( 4.7A)
None
CYC  B 175 (-3.4A)
None
 1.23A 1kxhA-1liaB:
undetectable		 1kxhA-1liaB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		3 / 3 LEU B  92
VAL B  95
LEU B  99
 None
 0.45A 1mz9B-1liaB:
undetectable		 1mz9B-1liaB:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 10 LEU B 122
ALA B  83
ILE B  56
GLY B  88
ILE B  90
 CYC  B 175 ( 4.5A)
CYC  B 175 (-3.4A)
None
CYC  B 175 ( 4.9A)
CYC  B 175 (-3.7A)
 0.92A 1t3rA-1liaB:
undetectable		 1t3rA-1liaB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 10 LEU B 122
ALA B  83
ILE B  56
GLY B  88
ILE B  90
 CYC  B 175 ( 4.5A)
CYC  B 175 (-3.4A)
None
CYC  B 175 ( 4.9A)
CYC  B 175 (-3.7A)
 0.99A 1t7iA-1liaB:
undetectable		 1t7iA-1liaB:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 10 LEU B  92
VAL B 162
ALA B 163
VAL B 170
VAL B 169
 None
 1.06A 2nnjA-1liaB:
undetectable		 2nnjA-1liaB:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 12 GLU B  89
SER B  96
TYR B  97
TYR A  18
VAL B  45
 None
 1.49A 2rguA-1liaB:
undetectable		 2rguA-1liaB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 11 GLU B  89
SER B  96
TYR B  97
TYR A  18
VAL B  45
 None
 1.48A 2rguB-1liaB:
undetectable		 2rguB-1liaB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		4 / 6 GLY B 153
ILE B 151
GLU B 152
ASP B 154
 CYC  B 176 (-3.7A)
CYC  B 176 (-3.8A)
None
None
 0.96A 3a7eA-1liaB:
undetectable		 3a7eA-1liaB:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 10 LEU B 122
ALA B  83
ILE B  56
GLY B  88
ILE B  90
 CYC  B 175 ( 4.5A)
CYC  B 175 (-3.4A)
None
CYC  B 175 ( 4.9A)
CYC  B 175 (-3.7A)
 0.96A 3lzvA-1liaB:
undetectable		 3lzvA-1liaB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 11 LEU B 122
ALA B  83
ILE B  56
GLY B  88
ILE B  90
 CYC  B 175 ( 4.5A)
CYC  B 175 (-3.4A)
None
CYC  B 175 ( 4.9A)
CYC  B 175 (-3.7A)
 0.97A 3spkA-1liaB:
undetectable		 3spkA-1liaB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 12 LEU B 122
ALA B  83
ILE B  56
GLY B  88
ILE B  90
 CYC  B 175 ( 4.5A)
CYC  B 175 (-3.4A)
None
CYC  B 175 ( 4.9A)
CYC  B 175 (-3.7A)
 1.01A 3spkB-1liaB:
undetectable		 3spkB-1liaB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 9 LEU B 122
ALA B  83
ILE B  56
GLY B  88
ILE B  90
 CYC  B 175 ( 4.5A)
CYC  B 175 (-3.4A)
None
CYC  B 175 ( 4.9A)
CYC  B 175 (-3.7A)
 1.12A 3u7sA-1liaB:
undetectable		 3u7sA-1liaB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 1lia R-PHYCOERYTHRIN
R-PHYCOERYTHRIN
(Polysiphonia
urceolata;
Polysiphonia
urceolata) 		4 / 7 ASP B   3
PHE B   5
GLY A 102
THR A   6
 None
 1.15A 3vnsA-1liaB:
undetectable		 3vnsA-1liaB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 12 GLU B  89
SER B  96
TYR B  97
TYR A  18
VAL B  45
 None
 1.50A 3w2tA-1liaB:
undetectable		 3w2tA-1liaB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1lia R-PHYCOERYTHRIN
R-PHYCOERYTHRIN
(Polysiphonia
urceolata;
Polysiphonia
urceolata) 		4 / 8 ASN B  32
PHE B  30
ILE A  31
ALA A  35
 None
 0.98A 4eyzA-1liaB:
undetectable		 4eyzA-1liaB:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1lia R-PHYCOERYTHRIN
R-PHYCOERYTHRIN
(Polysiphonia
urceolata;
Polysiphonia
urceolata) 		4 / 8 ASN B  32
PHE B  30
ILE A  31
ALA A  35
 None
 0.98A 4eyzB-1liaB:
undetectable		 4eyzB-1liaB:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 12 PHE A 133
TYR A 119
SER A 126
CYH A  84
ILE A  88
 None
None
None
CYC  A 175 (-1.8A)
None
 1.09A 4krhA-1liaA:
undetectable		 4krhA-1liaA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 12 PHE A 133
TYR A 119
SER A 126
CYH A  84
ILE A  88
 None
None
None
CYC  A 175 (-1.8A)
None
 1.15A 4krhB-1liaA:
undetectable		 4krhB-1liaA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 11 LEU B 122
ALA B  83
ILE B  56
GLY B  88
ILE B  90
 CYC  B 175 ( 4.5A)
CYC  B 175 (-3.4A)
None
CYC  B 175 ( 4.9A)
CYC  B 175 (-3.7A)
 0.91A 4q1xA-1liaB:
undetectable		 4q1xA-1liaB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		4 / 4 THR A   6
GLY A 105
ASP A 108
SER A   3
 None
 1.19A 4rfqA-1liaA:
undetectable		 4rfqA-1liaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 12 ASN B  63
CYH B  75
ARG B  80
CYH B  84
LEU B  66
 None
CYC  B 175 (-3.5A)
CYC  B 175 (-3.9A)
CYC  B 175 (-1.8A)
CYC  B 175 ( 4.8A)
 1.42A 5lsuA-1liaB:
undetectable		 5lsuA-1liaB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		5 / 12 GLY B 123
ASN B  63
CYH B  75
CYH B  84
LEU B  66
 None
None
CYC  B 175 (-3.5A)
CYC  B 175 (-1.8A)
CYC  B 175 ( 4.8A)
 1.27A 5lsuA-1liaB:
undetectable		 5lsuA-1liaB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		4 / 7 VAL A  52
ARG A  93
TYR B  18
LEU A 107
 None
CYC  A 175 ( 4.9A)
None
None
 1.01A 5umwB-1liaA:
undetectable
5umwE-1liaA:
undetectable		 5umwB-1liaA:
18.90
5umwE-1liaA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1lia R-PHYCOERYTHRIN
(Polysiphonia
urceolata) 		4 / 7 VAL B  52
ARG B  93
TYR A  18
LEU B 107
 None
 1.12A 5umwB-1liaB:
undetectable
5umwE-1liaB:
undetectable		 5umwB-1liaB:
16.29
5umwE-1liaB:
16.29